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Animal Experimental Methods in the Study of Antiepileptic Drugs

  • Chapter
Antiepileptic Drugs

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 74))

Abstract

Animal experiments with antiepileptic drugs serve a variety of purposes. First, they are used for screening newly synthesized chemical compounds before these are investigated in patients; i.e., animals are used at an early stage to provide information which is more or less reliable, on whether a new agent is able to combat, with adequate efficacy, potency, and duration of action, the most important symptom of epilepsy, the seizure. In a more advanced phase of the screening procedure, animal experiments, usually of a more complex nature, are used to test the possible specific efficacies of new compounds against distinct forms of seizures.

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Authors
  1. W. P. Koella
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  2. G. D. Gladding
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  3. H. J. Kupferberg
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  4. E. A. Swinyard
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Editors and Affiliations

  1. Laboratorium für Pharmakologie und Toxikologie Fachbereich Veterinärmedizin, Freie Universität Berlin, Koserstraße 20, D-1000, Berlin 33, Germany

    Hans-Hasso Frey

  2. Abteilung für Neurologie, Klinikum Charlottenburg, Spandauer Damm 130, D-1000, Berlin 19, Germany

    Dieter Janz

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Koella, W.P., Gladding, G.D., Kupferberg, H.J., Swinyard, E.A. (1985). Animal Experimental Methods in the Study of Antiepileptic Drugs. In: Frey, HH., Janz, D. (eds) Antiepileptic Drugs. Handbook of Experimental Pharmacology, vol 74. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69518-6_12

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  • DOI: https://doi.org/10.1007/978-3-642-69518-6_12

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