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Hepatic Disposition and Elimination of Biliary Contrast Media

  • Chapter
Radiocontrast Agents

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 73))

Abstract

A variety of iodinated organic compounds are used clinically for oral cholecystography and for intravenous cholangiography. The specific physiologic and biochemical factors responsible for establishing the preference of these contrast media (CM) for hepatic elimination are not well established. Much of the early information concerning these organic compounds used as CM has been published [1]. In addition several more recent review articles have appeared [2–6]. However, during the past few years, a significant amount of new information has been reported about the mechanism of hepatic transport of many of these biliary CM. In addition, strides have been made in our understanding of hepatic and biliary physiology. The purpose of this chapter is to provide a general discussion of hepatic and biliary physiology and to summarize the more recent information concerning the pharmacology and hepatic disposition of biliary CM.

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  1. J. L. Barnhart
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  1. School of Medicine, Department of Radiology, S-009, University of California in San Diego, La Jolla, CA, 92093, USA

    Milos Sovak

  2. Biophysica Foundation, 3333 Torrey Pines Ct., La Jolla, CA, 92037, USA

    Milos Sovak

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Barnhart, J.L. (1984). Hepatic Disposition and Elimination of Biliary Contrast Media. In: Sovak, M. (eds) Radiocontrast Agents. Handbook of Experimental Pharmacology, vol 73. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69515-5_8

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