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Sulphonamides and Sulphones

  • Chapter
Antimalarial Drug II

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 68 / 2))

Abstract

This chapter is focused on the sulphonamides and sulphones1 which are in current use as antimalarial drugs (mostly in combination with pyrimethamine). These are, mainly, the sulphonamides sulfamonomethoxine, sulfadoxine and sulfalene, the sulphone dapsone and, to some extent, also the derivatives of dapsone, diformyldapsone and acedapsone. Only the properties of the single drugs are discussed. (For those of the combinations with pyrimethamine and other inhibitors of dihydrofolic acid reductase, see this part, Chap. 6.) The sulphonamide probably best known, sulfadiazine, is included in most paragraphs as a reference, although it is not considered an antimalarial.

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  1. H. J. Scholer
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  2. R. Leimer
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  3. R. Richle
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Editors and Affiliations

  1. London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, Great Britain

    Wallace Peters M.D., DSc, FRCP, DTM & H (Professor of Medical Protozoology) (Professor of Medical Protozoology)

  2. Wellcome Research Laboratories, Ravens Lane, Berkhamsted, Herts., HP4 2DY, Great Britain

    William H. G. Richards BSc, Ph. D. (Manager, Scientific Advisory Services) (Manager, Scientific Advisory Services)

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Scholer, H.J., Leimer, R., Richle, R. (1984). Sulphonamides and Sulphones. In: Peters, W., Richards, W.H.G. (eds) Antimalarial Drug II. Handbook of Experimental Pharmacology, vol 68 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69254-3_4

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