Abstract
Cerebral perfusion pressure (CPP), defined as the difference between mean arterial blood pressure (MABP) and intracranial pressure (ICP), determines cerebral blood flow (CBF). In the intact brain, coupling between metabolic demand and substrate supply ensures adequate CBF over a wide range of CPP. Within the range of autoregulation, changes in cerebral vascular resistance (CVR) enable adequate CBF in spite of falling CPP. The minimal adequate CPP in adults has been reported to be 40 mm Hg (Miller et al. 1972) and 30 mm Hg in newborn infants (Raju et al. 1982).
We are endebted to Michael Gafni for her expert technical assistance in the cat experiments
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References
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© 1983 Springer-Verlag Berlin · Heidelberg
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Goitein, K.J., Fainmesser, P., Sohmer, H. (1983). The Relationship Between Cerebral Perfusion Pressure and Auditory Nerve Brain Stem Evoked Response — Diagnostic and Prognostic Implications. In: Ishii, S., Nagai, H., Brock, M. (eds) Intracranial Pressure V. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69204-8_79
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DOI: https://doi.org/10.1007/978-3-642-69204-8_79
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