Skip to main content

Inflammatory Disease of the Human Lung of Definite or Presumed Viral Origin. Cytologic and Histologic Topics

  • Conference paper
Pulmonary Diseases

Part of the book series: Current Topics in Pathology ((CT PATHOLOGY,volume 73))

Abstract

A large part, perhaps even the majority, of inflammatory diseases of the respiratory tract are caused by viral infection. The pathoanatomical changes associated with banal viral infections (common cold) of the upper respiratory tract, may be readily observed in biopsies from the nasal mucosa as documented in studies by Hilding (1930) and Tyrell and Parsons (1960).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  • Adams JM (1941) Primary virus pneumonitis with cytoplasmic inclusion bodies. Jama 116:925–933

    Google Scholar 

  • Adams JM, Imagawa DT, Zike K (1961) Epidemic bronchiolitis and pneumonitis related to respiratory syncytial virus. Jama 176:1037–1039

    PubMed  CAS  Google Scholar 

  • Aherne W, Bird T, Court SDM, Gardner PS, McQuillen J (1970) Pathological changes in virus infections of the lower respiratory tract in children. J Clin Pathol 23:7–18

    PubMed  CAS  Google Scholar 

  • Alagna G (1911) Histopathologische Veränderungen der Tonsillen und der Schleimhaut der ersten Luftwege bei Masern. Arch Laryng Rhin 25:527–530

    Google Scholar 

  • Almeida JD (1963) A classification of virus particles based on morphology. Can Med Assoc J 89:787–798

    PubMed  CAS  Google Scholar 

  • Archibald RWR, Weller RO, Meadow SR (1971) Measles pneumonia and the nature of the inclusion-bearing giant cells: A light- and electronmicroscope study. J Pathol 103:27–34

    PubMed  CAS  Google Scholar 

  • Arrobbio J (1964) Infection with parainfluenza 3 virus: a fatal case with autopsy report. Clin Proc Child Hosp Nat Med Cent 20:298–305

    Google Scholar 

  • Beale AJ, Doane F, Ormsby HL (1957) Studies on adenovirus infections of the eye in Toronto. Am J Opthalmol 43:26–31

    CAS  Google Scholar 

  • Becroft DMO (1967) Histopathology of fatal adenovirus infection of the respiratory tract in young children. J Clin Pathol 20:561–569

    PubMed  CAS  Google Scholar 

  • Beem M, Wrigth FH, Hamre D, Egerer R, Oehme M (1960) Association of the chimpanzee coryza agent with acute respiratory disease in children. N Engl J Med 263: 523–530

    PubMed  CAS  Google Scholar 

  • Bell JA, Dingle JH, Francis T, Hilieman MR, Huebner RJ, Payne AM-M (1956)

    Google Scholar 

  • “Adenoviruses”: Group name proposed for new respiratory tract viruses. Science 124:119–120

    Google Scholar 

  • Bellanti JA (1971) Biologic significance of the secretory yA immunoglobulins. Pediatrics 48:715–729

    PubMed  CAS  Google Scholar 

  • Blandford G (1970) Arthus reaction and pneumonia. Br Med J I:758–760

    Google Scholar 

  • Blank H, Davis C, Collins C (1970) Electron microscopy for diagnosis of cutaneous viral infections. Br J Dermatol 83:69–80

    PubMed  Google Scholar 

  • Brody AR, Craighead JE (1974) Pathogenesis of pulmonary cytomegalovirus infection in immunosuppressed mice. J Infect Dis 129:677–689

    PubMed  CAS  Google Scholar 

  • Buescher EL (1967) Respiratory disease and the adenoviruses. Med Clin North Am 51:769–779

    PubMed  CAS  Google Scholar 

  • Burnett FM (1968) Measles as an index of immunological function. Lancet II:610–613

    Google Scholar 

  • Buser F (1967) Side reaction to measles vaccination suggesting the Arthus phenomenon. N Engl J Med 277:250–251

    PubMed  CAS  Google Scholar 

  • Buthala BA, Soret MG (1964) Parainfluenzy type 3 virus infection in hamsters: virologic, serologic and pathologic studies. J Infect Dis 114:226–234

    PubMed  CAS  Google Scholar 

  • Carilli AD, Gohd RS, Gordon W (1964) A virologic study of chronic bronchitis. N Engl J Med 270:123–127

    PubMed  CAS  Google Scholar 

  • Cascardo H, Karzon DT (1965) Measles virus giant cell inducing factor (fusing factor). Virology 26:311–325

    PubMed  CAS  Google Scholar 

  • Chanock RM, Parrott RH (1965) Respiratory syncytial virus. In: Horsfall FL Jr, Tamm I (eds) Viral and rickettsial diseases of man. Lippincott, Philadelphia, pp 775–783

    Google Scholar 

  • Chanock RM, Parrott RH, Kapikian AZ, Kein HW, Brandt CD (1968) Possible role of immunological factors in pathogenesis of RS virus lower respiratory tract disease. In: Pollard M (ed) Perspectives in virology, vol VI. Academic Press, New York, pp 125–139

    Google Scholar 

  • Chanock RM, Kapikian AZ, Mills J, Kein HW, Parrott RH (1970) Influence of immunological factors in respiratory syncytial virus disease of the lower respiratory tract. Arch Environ Health 21:347–355

    PubMed  CAS  Google Scholar 

  • Chany C, Lépine P, Lelong M, Le-Tan Vinh, Satge O, Virat J (1958) Severe and fatal pneumonia in infants and young children associated with adenovirus infections. Am J Hyg 67:367–378

    PubMed  CAS  Google Scholar 

  • Choppin PW, Scheid A (1980) The role of viral glykoproteins in adsorption, penetration and pathogenicity of viruses. Rev Infect Dis 2:40–60

    PubMed  CAS  Google Scholar 

  • Chown B (1939) Giant cell pneumonia of infancy as a manifestation of vitamin A deficiency. Am J Dis Child 57:489–505

    Google Scholar 

  • Coates HV, Chanock RM (1962) Experimental infection with respiratory syncytial virus in several species of animals. Am J Hyg 76:302–312

    PubMed  CAS  Google Scholar 

  • Cohen SM, Gordon J, Rapp F, Macauley JC, Bickley SM (1955) Cited by Spencer. Proc Soc Exp Biol Med 90:118

    PubMed  CAS  Google Scholar 

  • Cole R, Kuttner AG (1926) A filtrable virus present in the submaxillary glands of guinea pigs. J Exp Med 44:855–873

    PubMed  CAS  Google Scholar 

  • Cowdry EV (1934) The problems of intranuclear inclusions in virus diseases. Arch Pathol 18:527–542

    Google Scholar 

  • Craighead JE (1971) Pulmonary cytomegalovirus infection in the adult. Am J Pathol 63:487–504

    PubMed  CAS  Google Scholar 

  • Dahm HH (1980) Zytomegalie des Neugeborenen und des Erwachsenen. Med Welt 31:64–69

    PubMed  CAS  Google Scholar 

  • Davis BJ, Ornstein L (1959) High resolution enzyme localization with a new diazo reagent, “hexazonium pararosaniline”. J Histochem Cytochem 7:297

    Google Scholar 

  • Deinhardt F, May RD, Calhoun HH, Sullivan HE (1958) The isolation of adenovirus type 1 from a fatal case of viral “pneumonitis”. Arch Intern Med 102:816

    CAS  Google Scholar 

  • Delage B, Bronchu P, Pelletier M, Jasmin G, Lapointe N (1979) Giant cell pneumonia caused by parainfluenza virus. J Pediatr 94:426–429

    PubMed  CAS  Google Scholar 

  • De Monbreun WA (1937) The histopathology of natural and experimental canine distemper. Am J Pathol 13:187–212

    Google Scholar 

  • Denton J (1925) The pathology of fatal measles. Am J Med Sci 169:531–543

    Google Scholar 

  • Dingle JH, Feller AE (1956) Noninfluenzal viral infections of the respiratory tract. N Engl J Med 254:465–471

    PubMed  CAS  Google Scholar 

  • Doane FW, Anderson N, Zbitnew A, Rhodes AJ (1969) Application of electron microscopy to the diagnosis of virus infections. Can Med Assoc J 100:1043–1049

    PubMed  CAS  Google Scholar 

  • Dürck H (1897) Studien über die Aetiologie und Histologie der Pneumonie im Kindesalter und die Pneumonien im Allgemeinen. Dtsch Arch Klin Med 58:368–444

    Google Scholar 

  • Effros RB, Doherty PC, Gerhard W, Bennink J (1977) Cited by Lin Yun Lu et al. (1981). J Exp Med 145:557–568

    PubMed  CAS  Google Scholar 

  • Enders JF (1956) The present status of etiologic discovery in viral diseases. Ann Intern Med 45:331–350

    PubMed  CAS  Google Scholar 

  • Enders JF, McCarthy FK, Mitus A, Cheatham WJ (1959) Isolation of measles virus at autopsy in cases of giant-cell pneumonia without rash. N Engl J Med 261:875–881

    PubMed  CAS  Google Scholar 

  • Evans AS (1958) Latent adenovirus infections of the human respiratory tract. Am J Hyg 67:256–266

    PubMed  CAS  Google Scholar 

  • Farber S, Wolbach SB (1932) Intranuclear and cytoplasmic inclusions (“protozoan-like bodies) in the salivary glands and other organs of infants. Am J Pathol 8:123–135

    PubMed  CAS  Google Scholar 

  • Farr GH, Russell AH, Hennigar GR (1970) Desquamative interstitial pneumonia. Am J Pathol 60:347–370

    PubMed  CAS  Google Scholar 

  • Feyrter F (1925) Ueber die Masernpneumonia. Virchows Arch 255:753–794

    Google Scholar 

  • Finkeldey W (1931) Über die Riesenzellbefunde in den Gaumenmandeln, zugleich ein Beitrag zur Histopathologic der Mandelveränderungen im Maserninkubationsstadium. Virchows Arch [Pathol Anat] 281:311–329

    Google Scholar 

  • Finkeldey W (1932) Riesenzellbefunde bei akuter Wurmfortsatzentzündung. Ein Beitrag zur Histopathologic der Veränderungen des Wurmfortsatzes im Maserninkubationsstadium. Virchows Arch [Pathol Anat] 284:528

    Google Scholar 

  • Fohlmeister I, Schaefer HE, Rieger M, Galanski M (1979) Masernriesenzellpneumonie. Med Welt 30:307–312

    PubMed  CAS  Google Scholar 

  • Francis T, Stuart-Harris CH (1938) Studies on nasal histology of epidemic influenza virus infection in ferret. J Exp Med 68:789–802

    PubMed  CAS  Google Scholar 

  • Frank L (1950) Varicella pneumonitis. Report of a case with autopsy observations. Arch Pathol Lab Med 50:450–456

    CAS  Google Scholar 

  • Friedländer (1876) Experimentaluntersuchungen über chronische Pneumonie und Lungenschwindsucht. Virchows Arch [Pathol Anat] 68:325–363

    Google Scholar 

  • Friedman HM (1981) Cytomegalovirus: subclinical infection or disease? Am J Med 70:215–217

    PubMed  CAS  Google Scholar 

  • Gardner PS, Turk DC, Aherne WA, Bird T, Holdaway MD, Court SDM (1967) Deaths associated with respiratory tract infection in childhood. Br Med J IV:316–320

    Google Scholar 

  • Geiler G (1957) Über die Erwachsenenform der Cytomegalie. Frankf Z Pathol 68:107–118

    Google Scholar 

  • Gerbeaux MJ, Héber-Jouas J, Masse N, Beauchchef A (1957) Epidémie familiale de maladie à virus du groupe A.P.C. chez trois enfants (un cas mortel). Bull Soc Méd Hôp Paris 73:519

    PubMed  CAS  Google Scholar 

  • Giese W (1960) Die Atemorgane. In: Kaufmann E, Staemmler M (eds) Lehrbuch der speziellen pathologischen Anatomie, vol II/3. de Gruyter, Berlin

    Google Scholar 

  • Glahn WC von, Pappenheimer AM (1925) Intranuclear inclusions in visceral disease. Am J Pathol 1:445–466

    Google Scholar 

  • Glezen WP, Loda FA, Clyde WA, Senior RJ, Shaeffer CI, Conley WG, Denny FW (1971) Epidemiologic patterns of acute lower respiratory disease of children in a pediatric group practice. J Pediatr 78:397–406

    PubMed  CAS  Google Scholar 

  • Goodpasture EW (1919) The significance of vertain pulmonary lesions in relation to the etiology of influenza. Am J Med Sci 158:863–870

    Google Scholar 

  • Goodpasture EW, Talbot FB (1921) Conerning the nature of “protozoan-like” cells in certain lesions on infancy. Am J Dis Child 21:415–425

    Google Scholar 

  • Goodpasture EW, Auerbach SH, Swanson HS, Cottir EF (1939) Virus pneumonia of infants secondary to epidemic infections. Am J Dis Child 57:937–1011

    Google Scholar 

  • Green RG, Evans CA (1939) Comparative study of distemper inclusions. Am J Hyg (Sect B) 29:73–87

    Google Scholar 

  • Gross PA, Green RH, McCrea-Curnen MG (1973) Persistent infection with parainfluenza type 3 virus in man. Am Rev Respir Dis 108:894–898

    PubMed  CAS  Google Scholar 

  • Günther M, Schaefer HE (1981) Nachweis von Viren in Speicheldrüsen europäischer und algerischer Igel — ein neuer Aspekt der Selbstbespeichelung. Dtsch Ges Säugetierkunde, Heidelberg

    Google Scholar 

  • Güthert H, Meerbach W, Wöckel W (1969) Vorkommen und Bedeutung der Riesenzellen in der Lunge. 2. Mitteilung: Die mehrkernigen Riesenzeilen. Zentralbl Allg Pathol 112:22–30

    PubMed  Google Scholar 

  • Hall CB (1931) Nosocomial viral respiratory infections: Perennial weeds on pediatric wards. Am J Med 70:670–676

    Google Scholar 

  • Hall CB, Kopeiman AE, Douglas RG, Geiman JM, Meagher MP (1979) Neonatal respiratory syncytial virus infection. N Engl J Med 300:393–396

    PubMed  CAS  Google Scholar 

  • Hamperl H (1956) Pneumocystis infection and cytomegaly of the lungs in the new-born and adult. Am J Pathol 32:1–13

    PubMed  CAS  Google Scholar 

  • Hathaway BM (1935) Generalized dissemination of giant cells in lymphoid tissue in prodromal stage of measles. Arch Pathol Lab Med 19:819–824

    Google Scholar 

  • Hecht V (1910) Die Riesenzellpneumonie im Kindesalter. Eine histologisch-experimentelle Studie. Beitr Pathol Anat Allg Pathol 48:263–310

    Google Scholar 

  • Hers JFPh (1963) Fluorescent antibody technique in respiratory viral diseases. Am Rev Dis [Suppl] 88:316–338

    Google Scholar 

  • Hers JFPh, Mulder J (1961) Broad aspects of the pathology and pathogenesis of human influenza. Am Rev Respir Dis 83(2):84–97

    PubMed  Google Scholar 

  • Hers JFPh, Masurel N, Mulder J (1958) Bacteriology and histopathology of the respiratory tract and lungs in fatal asian influenza. Lancet II:1141–1143

    Google Scholar 

  • Hilding A (1930) The common cold. Arch Otolaryngol 12:33–150

    Google Scholar 

  • Hilleman MR, Werner JH (1954) Recovery of new agent from patients with acute respiratory illness. Proc Soc Exp Biol Med 85:183–188

    PubMed  CAS  Google Scholar 

  • Himmelweit F (1943) Influenza virus B isolated from fatal case of pneumonia. Lancet II:793–794

    Google Scholar 

  • Holzel A, Parker L, Patterson WH, White LLR, Thompson KM, Tobin JOH (1963) The isolation of respiratory syncytial virus from children with acute respiratory disease. Lancet I:295–298

    Google Scholar 

  • Holzel A, Parker L, Patterson WH, Cartmel D, White LLR, Purdy R, Thompson KM, Tobin JOH (1965) Virus isolations from throats of children admitted to hospital with respiratory and other diseases, Manchester 1962–4. Br Med J I:614–619

    Google Scholar 

  • Hsiung CG (1963) Adenovirus pneumonia in infants and children. Pathologic studies of 40 cases. Chin Med J (Engl) 82:390–398

    CAS  Google Scholar 

  • Ishida N (1957) Cited by Wöckel and Meerbach (1968). Ann NY Acad Sci 67:299

    Google Scholar 

  • Jarvis WR, Middleton PJ, Gelfand EW (1979) Parainfluenza pneumonia in severe combined immunodeficiency disease. J Pediatr 94:423–524

    PubMed  CAS  Google Scholar 

  • Jensen KE, Minuse E, Ackermann WW (1955) Serologic evidence of American experience with newborn pneumonitis virus (type Sendai). J Immunol 75:71–77

    PubMed  CAS  Google Scholar 

  • Jesionek Kiolemenoglou (1904) Ueber einen Befund von protozoenartigen Gebilden in den Organen eines hereditär-luetischen Fötus. Münch Med Wochenschr 51:1905–1907

    Google Scholar 

  • Joncas J, Berthiaume L, Pavilanis V (1969a) The structure of the respiratory syncytial virus. Virology 38:493–496

    PubMed  CAS  Google Scholar 

  • Joncas JH, Williams R, Berthiaume L, Beaudry P, Pavilanis V (1969b) Diagnosis of viral respiratory infections by electron microscopy. Lancet I:956–959

    Google Scholar 

  • Karsner HT, Meyers AE (1913) Giant cell pneumonia. Arch Intern Med 11:534–541

    Google Scholar 

  • Kawai K (1959) Pathology and pathologic anatomy of adenovirus infection; based on 3 autopsy cases of infantile pneumonia. Jpn J Exp Med 29:359–368

    PubMed  CAS  Google Scholar 

  • Klein PJ, Bulla M, Newman RA, Müller P, Uhlenbruck G, Schaefer HE, Krüger G, Fischer R (1977) Thomsen-Friedenreich Antigen in haemolytic-uraemic syndrome. Lancet II:1024–1025

    Google Scholar 

  • Klein PJ, Bulla M, Newman RA, Müller P, Uhlenbruck G, Krüger G, Schaefer HE, Lennartz KJ (1978a) Untersuchungen zur Pathogenese des hämolytisch-urämischen Syndroms. Zentralbl Allg Pathol 122:280

    Google Scholar 

  • Klein PJ, Newman RA, Uhlenbruck G, Schaefer HE, Lennartz KJ, Fischer R (1978b) Histochemical methods for the demonstration of Thomsen-Friedenreich antigen in cell suspensions and tissue sections. Klin Wochenschr 56:761–765

    PubMed  CAS  Google Scholar 

  • Klein PJ, Bulla M, Newman RA, Radermacher EH, Müller P, Uhlenbruck G, Krüger G, Schaefer HE, Lennartz KJ, Fischer R (1979) The significance of pneumococcal neuraminidase for the development of haemolytic-uraemic syndrome. In: Bulla M (ed) Dialysis and kidney transplantation in children. Problems and particularities of intermittent longterm dialysis and acute renal failure in children. Bibliomed, Melsungen, pp 183–189

    Google Scholar 

  • Knyvett AF (1963) The pulmonary lesions of chickenpox. Q J Med 35(N.S.):313–323

    Google Scholar 

  • Kromayer E (1889) Ueber die sogenannte Katarrhalpneumonie nach Masern und Keuchhusten. Arch Pathol Anat 117:452–468

    Google Scholar 

  • Kuttner AG, T’Ung T (1935) Further studies on the submaxillary gland viruses of rats and guinea pigs. J Exp Med 62:805–822

    PubMed  CAS  Google Scholar 

  • Laver WG, Kilbourne ED (1966) Identification in a recombinant influenza virus of structural proteins derived from both parents. Virology 30:493–501

    PubMed  CAS  Google Scholar 

  • Leder LD (1964) Über die selektive fermentcytochemische Darstellung von neutrophilen myeloischen Zellen und Gewebsmastzellen im Paraffinschnitt. Klin Wochenschr 42:553–555

    PubMed  CAS  Google Scholar 

  • Lelong M, Lépine P, Alison F, Le-Tan-Vinh, Satgé P, Chany Ch (1956) La pneumonie à virus du groupe A.P.C. chez le nourrisson. Isolement du virus. Les lésions anatomo-histologiques. Arch Fr Pediatr 13:1092–1096

    PubMed  Google Scholar 

  • Liebow AA, Steer A, Billingsley JG (1965) Desquamative interstitial pneumonia. Am J Med 39:369–404

    PubMed  CAS  Google Scholar 

  • Lin Yun Lu, Askonas B (1981) Cross-reactivity for different type A influenza viruses of a cloned T-killer cell line. Nature 288:164–165

    Google Scholar 

  • Lipschütz Ng (1921) Untersuchungen über die Ätiologie der Krankheiten der Herpesgruppe (Herpes zoster, Herpes genitalis, Herpes febrilis). Arch Dermatol Syph 136:428–482

    Google Scholar 

  • Llanos-Rodas R, Liu C (1965) A study of measles virus infection in tissue culture cells with particular reference to the development of intranuclear inclusion bodies. J Immunol 95:840–845

    Google Scholar 

  • Löblich H-J (1981) Personal communication

    Google Scholar 

  • Löwenstein C (1907) Über protozoenartige Gebilde in den Organen von Kindern. Zentralblatt Allg Pathol Pathol Anat 18:518–518

    Google Scholar 

  • Louria DB, Blumenfeld HL, Ellis JT, Kilbourne ED, Rogers DE (1959) Studies of influenza in the pandemic of 1957–1958. II. Pulmonary complications of influenza. J Clin Invest 38:213–265

    PubMed  CAS  Google Scholar 

  • Lucchesi PF, La Boccetta AC, Peale AR (1947) Varicella neonatorum. Am J Dis Child 73:44–54

    PubMed  CAS  Google Scholar 

  • Luse SA, Smith MG (1965) Electron microscope studies of cells infected with the salivary gland viruses. Ann NY Acad Sci 81:133–144

    Google Scholar 

  • Martin AM, Kurtz SM (1966) Cytomegalic inclusion disease. An electron microscopic study of the virus at necropsy. Arch Pathol Lab Med 82:27–34

    Google Scholar 

  • Martin CM, Kunin CM, Gottlieb LS, Fuland M (1959) Asian influenza A in Boston, 1957–1958. II. Severe staphylococcal pneumonia complicating influenza. Arch Intern Med 103:532–542

    CAS  Google Scholar 

  • Masson P, Paré L (1931) Un cas de broncho-pneumonie à plasmodes. Contribution à Fétude du revêtement alvéolaire. Ann Anat Pathol (Paris) 8:13–35

    Google Scholar 

  • Masugi M, Minami G (1938) Über einen Fall von Masern mit Riesenzellbildung an Luftwegen, Mund- und Rachenschleimhaut. Über die Einschlüsse an Masernriesenzellen. Beitr Pathol Anat Allg Pathol 101:483–502

    Google Scholar 

  • McAllister RM, Straw RM, Filbert JE, Goodheart CR (1963) Human cytomegalovirus: Cytochemical observations of intracellular lesion development correlated with viral synthesis and release. Virology 19:521–531

    CAS  Google Scholar 

  • McClelland AJ (1980) Vaccination against paramyxoviruses. Nature 284:404

    PubMed  CAS  Google Scholar 

  • McNair Scott TF, Bonanno DE (1967) Reactions to live-measles virus vaccine in children previously inoculated with killed-virus vaccine. N Engl J Med 277:248–250

    Google Scholar 

  • McNary WF, Gaensler EA (1971) Intranuclear inclusion bodies in desquamative interstitial pneumonia: Electron microscopic observations. Ann Intern Med 74:404–407

    PubMed  Google Scholar 

  • Meerbach W, Wöckel W, Güthert H (1968) Vorkommen und Bedeutung der Riesenzellen in der Lunge. 1. Mitteilung: Die einkernigen Riesenzellen. Zentralbl Allg Pathol Pathol Anat 111:544–550

    CAS  Google Scholar 

  • Merz DC, Scheid A, Choppin PW (1980) Importance of antibodies to the fusion glycoprotein of paramyxoviruses in the prevention of spread of infection. J Exp Med 151:275–288

    PubMed  CAS  Google Scholar 

  • Mitus A, Enders JF, Craig JM, Holloway A (1959) Persistence of measles virus and depression of antibody formation in patients with giant cell pneumonia. N Engl J Med 261:882–889

    PubMed  CAS  Google Scholar 

  • Moloney WC, McPherson K, Fliegelman L (1960) Esterase activity in leucocytes demonstrated by the use of naphthol AS-D chloroacetate substrate. J Histochem Cytochem 8:200–207

    PubMed  CAS  Google Scholar 

  • Moore RA, Gross P (1930) Giant cells in inflammation of the lung in children. Am J Dis Child 40:247–259

    Google Scholar 

  • Mouchet R (1911) De la présence de protozoaires dans les organes des enfants. Contribution à l’étude de l’ictère des nouveau-nés. Arch Med Exp Anat Pathol (Paris) 23:115–124

    Google Scholar 

  • Muchmore HG, Parkinson AJ, Humphries JE, Scott LV, Cooney MK, Miles JAR (1981) Persistent parainfluenza virus shedding during isolation at the south pole. Nature 289:187–189

    PubMed  CAS  Google Scholar 

  • Mufson MA, Krause HE, Mocega HE, Dawson FW (1970) Viruses, mycoplasma pneumoniae and bacteria associated with lower respiratory tract disease among infants. Am J Epidemiol 91:192–202

    PubMed  CAS  Google Scholar 

  • Mulder J, Verdongk GJ (1949) Studies on the pathogenesis of a case of influenza-A pneumonia of 3 days duration. J Pathol Bacteriol 61:55–61

    Google Scholar 

  • Myerowitz RL, Stalder H, Oxman MN, Levin MJ, Moore M, Leith JD, Gantz NM, Pellegrini J, Hierholzer JC (1975) Fatal disseminated adenovirus infection in a renal transplant recipient. Am J Med 59:591–598

    PubMed  CAS  Google Scholar 

  • Nader PR, Horwitz M, Rouseau J (1967) Severe illness (atypical exanthem) following exposure to natural measles: II cases in children previously inoculated with killed vaccine. Presented at a meeting of the American Pediatric Society April, 29

    Google Scholar 

  • Noda K (1953) Newborn virus pneumonitis, type Sendai. III. Report: Pathological studies on the 9 autopsy cases and the mice inoculated with the new-found virus. Yokohama Med Bull 4:281–287

    PubMed  CAS  Google Scholar 

  • Norrby E (1966) Present status of killed measles vaccines. Proc Int Conf Vaccines viral ricketsial Dis Man, Washington

    Google Scholar 

  • Oppenheimer EH (1944) Congenital chickenprox with disseminated visceral lesions. Bull Johns Hopkins Hosp 74:240–250

    Google Scholar 

  • Osada R, Hanayama R (1958) A fatal case of infantile pneumonia due to adenovirus; clinical findings. Jpn J Exp Med 28:293–295

    PubMed  CAS  Google Scholar 

  • Parker F, Jolliffe LS, Barnes MW, Finland M (1946) Pathologic findings in the lungs of five cases from which influenza virus was isolated. Am J Pathol 22:797–819

    CAS  Google Scholar 

  • Patchefsky AS (1971) Desquamative interstitial pneumonia: significance of intranuclear viral-like inclusion bodies. Ann Intern Med 74:322–327

    PubMed  CAS  Google Scholar 

  • Patchefsky AS, Fraimow W, Hoch WS (1973) Desquamative interstitial pneumonia. Pathological findings and follow-up in 13 patients. Arch Intern Med 132:222–225

    PubMed  CAS  Google Scholar 

  • Pettavel CA (1911) Über eigentümliche herdförmige Degenerationen der Thyreoidea-Epithelien bei Purpura eines Neonatus. Virchows Arch [Pathol Anat] 206:1–11

    Google Scholar 

  • Pinkerton H, Smiley WL, Anderson WAD (1945) Giant cell pneumonia with inclusions. A lesion common to Hecht’s disease, distemper and measles. Am J Pathol 21:1–23

    PubMed  CAS  Google Scholar 

  • Pisano G (1910) Su di un reperto istologico raro in feto scleromatoso. Gazz Osp 31:249–250

    Google Scholar 

  • Rauh LW, Schmidt R (1965) Measles immunization with killed virus vaccine: serum antibody titers and experience with exposure to measles epidemic. Am J Dis Child 109:232–237

    PubMed  CAS  Google Scholar 

  • Rector EJ, Rector BS (1934) Intranuclear inclusions in the salivary glands of moles. Am J Pathol 10:629–637

    PubMed  CAS  Google Scholar 

  • Reynolds EOR (1967) Bronchiolitis. In: Kendig EL (ed) Disorders of the respiratory tract in children. Saunders, Philadelphia

    Google Scholar 

  • Ribbert H (1904) Ueber protozoenartige Zellen in der Niere eines syphilitischen Neugeborenen und in der Parotis von Kindern. Zentralbl Allg Pathol Pathol Anat 15:945–948

    Google Scholar 

  • Roberts GBS, Bain AD (1958) The pathology of measles. J Pathol Bacteriol 76:111–118

    PubMed  CAS  Google Scholar 

  • Roetterink F (in preparation) Epidemiologisch-klinische und pathologisch-anatomische Beobachtungen für Influenzaepidemien mit A2 Hongkong/1/68. Inauguraldissertation, Hannover (and personal communication 1981)

    Google Scholar 

  • Rowe WP, Huebner RJ, Gilmore LK, Parrott RH, Ward TG (1953) Isolation of a cytopathogenic agent from human adenoids undergoing spontaneous degeneration in tissue culture. Proc Soc Exp Biol Med 84:570–573

    PubMed  CAS  Google Scholar 

  • Ruebner BH, Hirano T, Slusser RJ, Medearis DN (1965) Human cytomegalovirus infection. Electron microscopic and histochemical changes in cultures of human fibroblasts. Am J Pathol 46:477–496

    PubMed  CAS  Google Scholar 

  • Sano T, Niitsu J, Nakagawa J, Ando T (1953) Newborn virus pneumonitis (Type Sendai) I. Report: Clinical observation of a new virus pneumonitis of the newborn. Yokohama Med Bull 4:199–216

    PubMed  CAS  Google Scholar 

  • Scadding JG (1974) Diffuse pulmonary alveolar fibrosis. Thorax 29:271–281

    PubMed  CAS  Google Scholar 

  • Scadding JG, Hinson KFW (1967) Diffuse fibrosing alveolitis (diffuse interstitial fibrosis of the lungs). Correlation of histology at biopsy with prognosis. Thorax 22:291–403

    PubMed  CAS  Google Scholar 

  • Schaefer H-E (1998) Ein atypisches Verteilungsmuster der tartratresistenten sauren Phosphatase in Osteoklasten bei Ostitis deformans Paget — zur pathogenetischen und diagnostischen Bedeutung. Verh Dtsch Ges Pathol 64:569

    Google Scholar 

  • Schaefer H-E (1981) The role of macrophages in storage disease. In: Schmalzl F, Huhn D, Schaefer H-E (eds) Disorders of the monocyte macrophage system. Pathophysiological and clinical aspects. Springer, Berlin Heidelberg New York. (Haematology and blood transfusion, vol 27, pp 121–130)

    Google Scholar 

  • Schaefer H-E, Müntefering H (1982) Histochemische Untersuchungen zur Abkunft intraalveolarer Zellen bei der desquamativen interstitiellen Pneumonie (Liebow). Ber Pathol 97:215

    Google Scholar 

  • Schaefer H-E, Hellriegel K-P, Fischer R (1977) Vorkommen tartrat-resistenter saurer Phosphatase in verschiedenen Zelltypen des lymphoretikulären und hämatopoetischen Zellsystems. Blut 34:393–397

    PubMed  CAS  Google Scholar 

  • Schneweis KE, Käckell MY, Nolte R, Sinapius D, Brandis H (1966a) Respiratorysyncytial-Virus-Infektionen im Kindesalter. Virologische Untersuchungen. Dtsch Med Wochenschr 91:53–55

    PubMed  CAS  Google Scholar 

  • Schneweis KE, Käckell MY, Nolte R, Sinapius D, Brandis H (1966b) Respiratorysyncytial-Virus-Infektionen im Kindesalter. Klinik und pathologische Anatomie. Dtsch Med Wochenschr 91:153–158

    PubMed  CAS  Google Scholar 

  • Seifert G, Oehme J (1957) Pathologie und Klinik der Cytomegalie. Thieme, Leipzig

    Google Scholar 

  • Shedden WJH, Emery JL (1965) Immunofluorescent evidence of respiratory syncytial virus infection in case of giantcell bronchiolitis in children. J Pathol Bacteriol 89:343–347

    PubMed  CAS  Google Scholar 

  • Sherman FE, Ruckle G (1958) In vivo and in vitro cellular changes specific for measles. Arch Pathol Lab Med 65:587–599

    CAS  Google Scholar 

  • Shope RE (1936) The influenzas of swine and man. The Harvey Lectures, 1935–36, p 183

    Google Scholar 

  • Shope RE, Francis T (1936) The susceptibility of swine to the virus of human influenza. J Exp Med 64:791–801

    PubMed  CAS  Google Scholar 

  • Sinigaglia G (1912) Osservazioni sul cimurro. Clin Vet (Milano) 35:421–446

    Google Scholar 

  • Smith MG (1959) The salivary gland viruses of man and animals (cytomegalic inclusion disease). Prog Med Virol 2:171–202

    Google Scholar 

  • Sobonya RE, Hiller C, Pingleton W, Watanabe J (1978) Fatal measles (rubeola) pneumonia in adults. Arch Pathol Lab Med 102:366–371

    PubMed  CAS  Google Scholar 

  • Sohier R, Bensimon P, Lagabrielle B (1957) Infection à adénovirus (type 7 prime) avec atteinte pulmonaire et rénale. Bull Soc Méd Hôp Paris 73:37–42

    PubMed  CAS  Google Scholar 

  • Sohier R, Chardonnet Y, Prunieras M (1965) Adenoviruses. Status of current knowledge. Prog Med Virol 7:253–325

    PubMed  CAS  Google Scholar 

  • Spencer H (1973) Pathology of the lung (excluding pulmonary tuberculosis), 2nd edn. Pergamon Press, Oxford

    Google Scholar 

  • Sperk-Bard E, Kaiserling E, Müller-Hermelink HK (1977) Letale Varizelleninfinektionen. Verh Dtsch Ges Pathol 61:452

    Google Scholar 

  • Strano AJ (1976) Light microscopy of selected viral diseases (morphology of viral inclusion bodies). Pathol Annu 11:53–75

    PubMed  CAS  Google Scholar 

  • Straub M, Mulder J (1948) Epithelial lesions in the respiratory tract in human influenzal pneumonia. J Pathol Bacteriol 60:429–434

    Google Scholar 

  • Taylor-Robinson D, Caunt AE (1972) Varicella virus. Virology monographs. Die Virusforschung in Einzeldarstellungen, Nr. 12. Springer, Wien

    Google Scholar 

  • Teng CH (1960) Adenovirus pneumonia epidemic among Peking infants and preschool children in 1958. Chin Med J (Engl) 80:331–339

    CAS  Google Scholar 

  • Timbury MC, Edmond E (1979) Herpesviruses. J Clin Pathol 32:859–881

    PubMed  CAS  Google Scholar 

  • Triebwasser JH, Harris RE, Bryant RE (1967) Varicella pneumonia in adults. Medicine 46:409–423

    PubMed  CAS  Google Scholar 

  • Tyrrell DAJ, Parsons R (1960) Some virus isolations from common colds. III. Cytopathic effects in tissue cultures. Lancet I:239–242

    Google Scholar 

  • Vivell OM, Axmann M, Lips G (1962) Die Epidemie von Respirationstrakterkrankungen im Winter 1961/62. Dtsch Med Wochenschr 87:1996–2003

    PubMed  CAS  Google Scholar 

  • Walsh JJ, Dietlein LF, Low FN, Burch GE, Mogabgab WJ (1961) Bronchotracheal response in human influenza. Type A, Asian strain, as studied by light and electron microscopic examination of bronchoscopic biopsies. Arch Intern Med 108:376–388

    PubMed  CAS  Google Scholar 

  • Waring JJ, Neubuerger K, Geever EF (1942) Severe forms of chickenpox in adults, with autopsy observations in a case with associated pneumonia and encephalitis. Arch Intern Med 69:384–408

    Google Scholar 

  • Warthin AS (1931) Occurrence of numerous large giant cells in the tonsils and pharyngeal mucosa in the prodromal stage of measles. Arch Pathol Lab Med 11:864–874

    Google Scholar 

  • Weinstein L, Meade RH (1956) Respiratory manifestations of chickenpox. Special consideration of features of primary varicella pneumonia. Arch Intern Med 98:91–99

    CAS  Google Scholar 

  • Weller RW (1952) Giant cell pneumonia with inclusions. Pediatrics 10:681–686

    PubMed  CAS  Google Scholar 

  • Weller TH (1971) The cytomegaloviruses: Ubiquitous agents with protean clinical manifestations. N Engl J Med 285:203–214 (I),

    PubMed  CAS  Google Scholar 

  • Weller TH (1971) The cytomegaloviruses: Ubiquitous agents with protean clinical manifestations. N Engl J Med 285:267–274 (II)

    PubMed  CAS  Google Scholar 

  • Wöckel W, Meerbach W (1968) Zur Morphologie der Lunge bei Viruskrankheiten im Säuglings- und Kindesalter. Dtsch Med Wochenschr 93:313–318

    PubMed  Google Scholar 

  • Wöckel W, Güthert H, Meerbach W (1963) Zur pathologischen Anatomie der Adenoviruspneumonie. Pathol Microbiol 26:768–788

    Google Scholar 

  • Wrigth HT, Beckwith JB, Gwinn JL (1964) A fatal case of inclusion body pneumonia in an infant infected with adenovirus type 3. J Pediatr 64:628–633

    Google Scholar 

  • Yam LT, Li CY, Lam KW (1971) Tartrate-resistant acid phosphatase isoenzyme in the reticulum cells of leukemic reticuloendotheliosis. N Engl J Med 284:357–360

    PubMed  CAS  Google Scholar 

  • Zakstelskaya LY, Almeida JD, Bradstreet CMP (1967) The morphological characterisation of respiratory syncytial virus by a simple electron microscope technique. Acta Virol (Praha) 11:420–423

    CAS  Google Scholar 

  • Zweerink HJ, Courtneidge SA, Skehel JJ, Crompton MJ, Askonas BA (1977) Cited by Lin Yun Lu et al. (1981) Nature 267:354–356

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1983 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Schaefer, HE. (1983). Inflammatory Disease of the Human Lung of Definite or Presumed Viral Origin. Cytologic and Histologic Topics. In: Müller, KM. (eds) Pulmonary Diseases. Current Topics in Pathology, vol 73. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69134-8_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-69134-8_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-69136-2

  • Online ISBN: 978-3-642-69134-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics