Abstract
We have proposed that some of the variability among individuals and populations in the location and rate of development of atherosclerosis is due to corresponding variations in the detailed geometry of susceptible arterial segments. The vascular geometry indirectly affects the atherogenic process by mediating the hemodynamic environment of the intima. Those geometric features which enhance atherogenic hemodynamic stresses can be regarded as “geometric risk factors”. Protocols have now been implemented to identify such factors; initial results suggest that, at the aortic bifurcation, two risk factors are branch angle variations and an offset flow divider tip.
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© 1983 Springer-Verlag Berlin Heidelberg
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Friedman, M.H., Deters, O.J., Mark, F.F., Bargeron, C.B., Hutchins, G.M. (1983). Geometric Effects on the Hemodynamic Environment of the Arterial Wall: A Basis for Geometric Risk Factors?. In: Schettler, G., Nerem, R.M., Schmid-Schönbein, H., Mörl, H., Diehm, C. (eds) Fluid Dynamics as a Localizing Factor for Atherosclerosis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69085-3_9
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DOI: https://doi.org/10.1007/978-3-642-69085-3_9
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