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Molecular Events in Axonal Regeneration

  • Conference paper
Repair and Regeneration of the Nervous System

Part of the book series: Dahlem Workshop Reports ((DAHLEM LIFE,volume 24))

Abstract

We consider whether a neuron must alter its program of gene expression in order to regenerate an injured axon. We conclude that certain information required for axon growth is encoded in the normal constituents of a quiescent axon, and certain aspects of axon growth may be regulated by environmental information impinging directly on the normal constituents of the axon. However, successful axon regeneration requires the introduction into the axon of a small number of new gene products that perform growth-specific functions. Because mammalian CNS neurons do not express these growth-related genes after axonal injury, their failure to regenerate their axons may be a consequence of the inability of the CNS to accomplish one of the steps in the sequence that leads from axon injury to the expression of growth-related genes.

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Author information

Authors and Affiliations

  1. Dept. of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO, 63110, USA

    M. Willard

  2. Dept. of Neurobiology, Stanford University School of Medicine, Stanford, CA, 94305, USA

    J. H. P. Skene

Authors
  1. M. Willard
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  2. J. H. P. Skene
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Editor information

J. G. Nicholls

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© 1982 Dr. S. Bernhard, Dahlem Konferenzen, Berlin

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Willard, M., Skene, J.H.P. (1982). Molecular Events in Axonal Regeneration. In: Nicholls, J.G. (eds) Repair and Regeneration of the Nervous System. Dahlem Workshop Reports, vol 24. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68632-0_6

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  • DOI: https://doi.org/10.1007/978-3-642-68632-0_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-68634-4

  • Online ISBN: 978-3-642-68632-0

  • eBook Packages: Springer Book Archive

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