Abstract
In rats, with an early stages of liver cirrhosis after chronic TAA treatment, hepatic ethylmorphine N-demethylation (EM) rate was not changed, whereas the rate of 7-ethoxycoumarin 0-deethylation (EC), and 7-ethoxyresorufin 0-deethylation (ERF) was enhanced. After phenobarbital administration to TAA treated rats the activities of EM and EC were markedly lower, whereas ERF rate was significantly higher, when compared to the phenobarbital-treated control rats. In rats with distinct nodular cirrhosis after TAA treatment, the basal rates and the rates after phenobarbital treatment of all three reactions were lower than those in the corresponding control rats. The induction of EC and ERF by 3-methylcholanthrene was only slightly diminished in the cirrhotic liver.
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© 1982 Springer-Verlag
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Müller, D., Zimmermann, T., Schiller, F. (1982). Drug Metabolism in Rat Liver Injured by Thioacetamide. In: Chambers, C.M., Chambers, P.L. (eds) New Toxicology for Old. Archives of Toxicology, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68511-8_69
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DOI: https://doi.org/10.1007/978-3-642-68511-8_69
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-11406-2
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