Abstract
An increasing concern over the LD50 study has become apparent over the years and even more so recently in Britain with the Home Office Publication on the subject and comments and opinions expressed in the National Press. Particularly with respect to the Pharmaceutical and Agrochemical Industries, the number of animals used depends on the number required to satisfy the Regulatory Authorities. Is there a scientific rationale for using the number of animals required? Data is presented justifying the use of smaller numbers of animals for establishing the acute toxicity of a chemical.
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Abbreviations
- LD50.:
-
The quantity of a substance estimated to kill half the number of animals exposed to it (Home Office Report on the LD50 test)
References
Griffith JF (1964) Inter-laboratory variations in the determination of acute oral LD50. Toxicol Appl Pharmacol 6: 726–730
Home Office (1979) Report on the LD50 test. HMSO, London
Trevan JW (1927) The error of determination of toxicity. Proc R Soc [B] 101: 483–514
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© 1982 Springer-Verlag
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Tattersall, M.L. (1982). Statistics and the LD50 Study. In: Chambers, C.M., Chambers, P.L. (eds) New Toxicology for Old. Archives of Toxicology, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68511-8_46
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DOI: https://doi.org/10.1007/978-3-642-68511-8_46
Publisher Name: Springer, Berlin, Heidelberg
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