Zusammenfassung
Die Ursachen akuter gastroduodenaler Blutungen sind vorwiegend streßbedingte Erosionen und Ulcera. In zweiter Linie kommen medikamentös induzierte Läsionen in Frage. Eine genaue Kenntnis über Häufigkeit und Spontanverlauf dieser Krankheit sind Voraussetzung für eine sinnvolle medikamentöse Therapie.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Aronsen KF, Wetterlin S, Ernas S, Voijtisek V, Mulder JL, Cort JH (1975) Die Wirkungen von Triglycyl-Lysin-Vasopressin auf Kontrollpersonen und Patienten mit Blutungen des oberen Gastrointestinaltraktes. Klin Wochenschr 53:747–753
Athanasoulis CA, Baum S, Waltman AC, Ring EJ, Imbembo A, Van der Salm TJ (1974) Control of acute gastric mucosal hemorrhage, intra-arterial infusion of posterior pituitary extract. N Engl J Med 290:597–603
Barr JW, Lakin RC, Rösch J (1975) Similarity of arterial and intravenous vasopressin on portal and systemic hemodynamics. Gastroenterology 69:13–19
Bauer H (1979) Cimetidin in der präoperativen Behandlung akut blutender gastroduodenaler Läsionen. M M W 121:1085–1088
Bauer H, Schmidt GF (1980) Tierexperimentelle und klinische Untersuchungen zur Kombination von Cimetidin und Somatostatin. Z Gastroenterol 18:314–319
Becker HD, Schafmyer A, Börgen HW (1979) Die Behandlung der Blutung aus akuten Schleimhautläsionen des Magens und Duodenums durch Sekretin. Chirurg 50:87–90
Biggs JC, Hugh TB, Dodds AJ (1976) Tranexamic acid and upper gastrointestinal hemorrhage — a double-blind trial. Gut 17:720–734
Brieler HS, Thiede A (1979) Zur Wirkung vasopressorischer Substanzen auf blutende Oesophagusvarizen und andere intestinale Blutungen. Zentralbl Chir 104:1337–1344
Bubrick MP, Wetherille RE, Onstad GR, Andersen RC, Hitchcok CR (1978) Control of acute gastroduodenal hemorrhage with Cimetidine. Surgery 84:510–518
Burland WL, Parr SN (1977) Experiences with Cimetidine in the treatment of seriously ill patients. Proceedings of the second international symposium on H2-receptor-antagonist. Excerpta Medica, Amsterdam Oxford Princeton, p 345–355
Carstensen HE, Bülow S, Hansen OH et al. (1980) Cimetidine for severe gastroduo-denal hemorrhage: 1. Randomized controlled trial. Scand J Gastroenterol 15:103–105
Cartier F, Gauthier-Lafave F, Larene L, Mottin J, Cara M, Passelece J (1980) Cimetidine in patients at risk of stressulcer: a multi-center controlled trial. Intensive Care Med 6:54
Conn HO, Ramsby GR, Storer EH et al. (1975) Intraarterial Vasopressin in the treatment of upper gastrointestinal hemorrhage: a prospective controlled clinical trial. Gastroenterology 68: 211–221
Cormack F, Chakrabart RR, Johar AJ, Fearnley GR (1973) Tranexamic acid in upper gastrointestinal hemorrhage. Lancet I:1027–1028
Cox HT, Poller L, Thomson JM (1967) Gastric fibrinolysis: a possible aetiological link with peptic ulcer. Lancet I:1300–1302
Creutzfeldt W, Arnold R (1978) Somatostatin and the stomach: exocrine and endocrine aspects. Metabolism 27 [Suppl]:1309–1315
Curtis LE, Simonian S, Buerk CA, Hirsch EF, Soroff HS (1973) Evaluation of the effectivenes of controlled pH in management of massive upper gastrointestinal bleeding. Am J Surg 125:474–476
Delaney JP, Michel HM, Bond J (1978) Cimetidine and gastric blood flow. Surgery 84:190–193
Desmond AM, Reynolds KW (1972) Erosive gastritis: its diagnosis, management and surgical treatment. Br J Surg 59:5–13
Douglas HO (1974) Levarterenol irrigation control of massive gastrointestinal bleeding in poor-risk patients. JAMA 230:1653–1657
Dunn DS, Silvis S, Onstaad G, Fischer R, Howard RJ, Delany JP (1977) The treatment of hemorrhage gastritis with the H2-blocking antihistamine, cimetidine. Gastroenterology 72:1053
Dykes PW, Kong JY, Hoare A, Hawkins CF, Mils JG (1977) Treatment of upper gastrointestinale hemorrhage with cimetidine. In proceedings of the second international symposium on H2-receptor-antagonist. Excerpta Medica, Amsterdam, p 334–337
Dykes PW, Hoare AM, Hawkins CF, Kang JX (1978) The treatment of upper gastrointestinal hemorrhage with cimetidin. In: Wastell C (ed) The Westminster Hospital Symposium. Livingstone Edinburgh Harlow New York, p 180–190
Ellis DM, Hamer JD, Baker SE (1977) Perforation of duodenal ulcer during treatment with cimetidine. Br Med J II:1583
Feely J, Wilkinson R, Wood AJ (1981) Reduction of liver blood and propranolol metabolism by cimetidin. N Engl J Med 304:692–695
Galmiche JP, Colin R, Veyrac M, Hecketsweiler P, Ouvry D, Teniere P, Ducrotte P (1979) Double-blind controlled trial of cimetidine in bleeding peptic ulcer. European Symposium, H2-Antagonists. Excerpta Medica, Amsterdam, p 164–171
Green FW, Kaplan MM, Curtis LE, Levine PH (1978) Effect of acid and pepsin on blood coagulation and platelet aggregation. A possible contribution to prolonged gastroduodenal mucosal hemorrhage. Gastroenterology 74:38–43
Gyr K, Kayasseh L (im Druck) Epidemiologie und Klinik der akuten gastroduodenalen Läsionen. In: Blum AL, Siewert JR (Hrsg) Ulcus Therapie. Ulcus ventriculi und Duodeni: Konservative und operative Therapie. Springer, Berlin Heidelberg New York, 2. Auflage in Druck
Halloran LG, Zfan AM, Gayle WE, Wheeler CB, Miller JD (1980) Prevention of acute gastrointestinal complications after severe head injury. A controlled trial of cimetidine prophylaxis. Am J Surg 139:44–48
Hastings PR, Skillmann JJ, Bushnell LS, Silen W (1978) Antacid titration in the prevention of acute gastrointestinal bleeding. A controlled randomized trial in 100 critically ill patients. N Engl J Med 298:1041–1045
Hermann V, Kaminski DL (1979) Evaluation of intragastric pH in acutely ill patients. Arch Surg 114:511–514
Hoare AM, Bradley GVH, Hawkins CF, Kang JY, Dykes PW (1979) Cimetidine in bleeding peptic ulcer. Lancet II:671–673
Jick H, Porter J (1978) Drug-induced gastrointestinal bleeding. Report from the Boston collaborative drug surveillance program, Boston University Medical Center. Lancet II:87–89
Johnson WC, Widrich WC (1975) Efficacy of selective splanchnic arteriography and vasopressin perfusion in diagnosis and treatment of gastrointestinal hemorrhage. Am J Surg 131:481–489
Kamada T, Fusamoto H, Kawano S et al. (1977) Gastrointestinal bleeding following head injury: A clinical study of 433 cases. J Trauma 17:44–47
Kamada T, Fusamoto H, Kawano S, Noguchi M, Hiramatsu K, Masuzaw AM, Sato N (1977) Acute gastroduodenal lesions in head injury. Am J Gastroenterol 68:249–253
Kayasseh L, Gyr K, Keller U, Stalder GA (1980) Somatostatin and cimetidin in pepticulcer hemorrhage. A randomised controlled trial. Lancet 1:844–846
Keller U, Sonnenberg GE, Kayasseh L, Gyr GK, Perruchoud A (1979) Dosisabhängigkeit der Wirkung von Somatostatin auf splanchnische Durchblutung beim Menschen. Schweiz Med Wochenschr 109:595–596
Kiselow M, Wagner M (1973) Intragastric instillation of levarterenol. Arch Surg 107:387–389
La Brooy SJ, Misiewicz JJ, Edwards J et al. (1979) Controlled trial of Cimetidine in upper gastrointestinal hemorrhage. Gut 20:892–895
Le Veen HH, Falk G, Diaz C et al. (1972) Control of gastrointestinal bleeding. Am J Surgery 123:154–159
Levine BA, Schwesinger WH, Sirinek KR, Jones D, Pruitt BA (1978) Cimetidine prevents reduction in gastric mucosal blood flow during shock. Surgery 84:113–119
Londong W, Londong V, Hanssen LE, Schwanner A (1981) Gastric effects and side effects of synthetic secretin in man. Regulatory peptide 2, 4:231–244
Lorenz W, Fischer M, Rohde H, Troidl H, Reimann HJ, Ohmann C (1980) Histamine and stress ulcer: New components in organizing a sequential trial on cimetidin Prophylaxis in seriously ill patient and defination of a special group at risk. Klin Wochenschr 58:653–665
Lucas CE, Sugarawa C, Riddle J, Rector F, Rosenberg B, Walt AJ (1971) Natural history and surgical dilemma of “stress” gastric bleeding. Arch Surg 102:266–273
Mac Donald AS, Steele BJ, Bottomley MG (1976) Treatment of stress-induced upper gastrointestinal hemorrhage with metiamide. Lancet 1:68–70
Mac Donald BRD, Williams R (1978) The role of cimetidine in the management of bleeding in liver disease. In: Wastel C (ed) Cimetidine: The Westminster Hospital Symposion. Livingstone, Edinburgh Harlow New York, p 180–190
Mac Dougal BRD, Bailey RJ, Williams R (1977) H2-Receptor antagonists and antacids in the prevention of acute gastrointestinal hemorrhage in fulminant hepatic failure. Lancet 1: 617–619
Macklon AF, Roberts SH, James O (1979) Cimetidine in bleeding peptic ulcer. Lancet II:1135–1136
Martin LF, Stalocher DK, David RN, Simonowitz A, Dellinger EP, Martin HM (1979) Failure of cimetidine prophylaxis in the critically ill. Arch Surg 115:492–496
Mc Alhany JC, Czwaja AJ, Pruitt BA (1976) Antacid control of complication from acute gastroduodenal disease after burns. J Trauma 16:645–649
Mc Elwee HP, Sivinek KR, Levine BA (1980) Cimetidine affords protection equal to antacids in prevention of stress ulceration following thermal injury. Surgery 86:620–628
Mielke C, Gerich JE, Lorenzi M, Tsalikian E, Rodvien R, Forsham PH (1975) The effect of somatostatin on coagulation and platelet function in man. N Engl J Med 293:480–483
Millette B, Huet PM, Lavoie P, Viallet A (1975) Portal and systemic effects of selective infusion of vasopressin into the superior mesenteric artery in cirrhotic patients. Gastroenterology 69:0–12
Palmer ED (1969) The vigorous diagnostic approach to upper-gastrointestinal tract hemorrhage. A 23-year prospective study of 1 400 Patients. JAMA 207:1477–1480
Pickard RG, Sanderson I, South M, Kirkham JS, Northfield TC (1979) Controlled trial of cimetidine in akute upper gastrointestinal bleeding. Br Med J 3:661–662
Priebe HJ, Skillman JJ, Bushnell LS, Long PC, Silen W (1979) Antacid versus cimetidine in prevention of acute gastrointestinal bleeding. N Engl J Med 302:661–662
Ponsky JL, Hoffmann M, Swayngim DS (1980) Saline irrigation in gastric hemorrhage. The effect of temperature. J Surg Res 28:204–205
Raptin S, Dollinger HC, Berger L von, Schlegel W, Schröder KE, Pfeiffer EF (1975) Effect of somatostatin on gastric secretin and gastrin release in man. Digestion 13:15–26
Rösch J, Dotter CT, Antonovic R (1972) Selective vasoconstrictor infusion in the management of arterio-capillary gastrointestinal hemorrhage. Am J Roentgenol Radium Ther Nucl Med 116:279–288
Schulz F, Schiessel R (1979) Therapie von Streß-Ulcusblutung mit Cimetidin. Dtsch Med Wochenschr: 104:1845–1848
Sherman LM, Shenoy SS, Cerra FB (1979) Selective intra-arterial vasopressin. Clinical efficaly and complications. Am Surg 189:298–302
Simonian S, Curtis LF (1976) Treatment of hemorrhage gastritis by antacid. Ann Surg 184:429–434
Speranza V, Basso N, Bogarani M, Fiorani S, Bianchi E, Materia A (1980) Prophylaxis of acute gastroduodenal mucosa lesions: a controlled trial. In: Torsoli A (ed) H2-antagonists, European Symposium. Experta Medice, Amsterdam
Stremple JF, Elliott DW (1975) Hemorrhage due to diffuse erosive gastritis. Arch Surg 110:606–612
Teichmann RK (1981) Der Einfluß von Somatostatin auf Streßulcusblutungen. Somatostatin: Klinische und experimentelle Ergebnisse. Münstersche Allgemeinchirurgische Symposien. 29.5.1981 Falk-Foundation. S. 55–60
Terés J, Bordas JM, Rimola A, Bru C, Rodes J (1980) Cimetidine in acute gastric mucosal bleeding: Results of a double-blind randomized trial. Dig Dis Sci 25:92–96
Wagner PK, Rothmund M (1980) Effekt von Cimetidin und Sekretin bei akuten Blutungen aus Magen und Duodenum. Ergebnisse einer prospektiven alternierenden Studie. Z Gastroenterol 18:337–341
Wahren J, Felig P (1976) Influence of somatostatin on carbonylhydrate disposal and absorption in diabetes mellitus. Lancet II:1213–1216
Waltman AC, Greenfield AJ, Novelline RA, Athanasoulis CA (1979) Pyloroduodenal bleeding and intraarterial vasopressin: clinical results. A J R 133:643–646
Wangensteen OH, Root HD, Jenson CB, Imamoglu K, Salmon PA (1958) Depression of gastric secretion and digestion by gastric hyperthermia: its clinical use in massive hematemesis. Surgery 44:265–274
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Kayasseh, L., Gyr, K. (1982). Medikamentöse Therapie. In: Siewert, J.R., Blum, A.L., Farthmann, E.H., Lankisch, P.G. (eds) Notfalltherapie. Interdisziplinäre Gastroenterologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68497-5_25
Download citation
DOI: https://doi.org/10.1007/978-3-642-68497-5_25
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-68498-2
Online ISBN: 978-3-642-68497-5
eBook Packages: Springer Book Archive