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The Role of Cyclic Nucleotides in the Control of Anterior Pituitary Gland Activity

  • Chapter
Cyclic Nucleotides

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 58 / 2))

Overview

The anterior pituitary gland secretes six known polypeptide hormones: ACTH (adrenocorticotropin), GH (growth hormone), PRL (prolactin), TSH (thyrotropin), LH (luteinizing hormone), and FSH (follicle-stimulating hormone). The rate of secretion of these individual polypeptides is specifically controlled by neurohormones released from the hypothalamus and transported to their adenohypophyseal site of action by a short portal blood system (Schally et al. 1968). The secretion of LH, FSH, and ACTH is known to be under only positive hypothalamic control, whereas that of GH, TSH, and PRL results from the balance of action of inhibitory and stimulatory neurohormones (Fig. 1). The overall influence of the hypothalamus on GH and TSH secretion is stimulatory, whereas it is inhibitory on PRL secretion.

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  1. F. Labrie
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Editors and Affiliations

  1. Biochemical Neuropharmacology Unit, National Institutes of Health, Room 5c 108/Bldg. 10, Bethesda, MD, 20205, USA

    John W. Kebabian

  2. Neuropharmacology Research Laboratory, Departments of Neurology and Pharmacology, Harvard Medical School, Massachusetts General Hospital, Fruit Street, Boston, MA, 02114, USA

    James A. Nathanson

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Labrie, F. et al. (1982). The Role of Cyclic Nucleotides in the Control of Anterior Pituitary Gland Activity. In: Kebabian, J.W., Nathanson, J.A. (eds) Cyclic Nucleotides. Handbook of Experimental Pharmacology, vol 58 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68393-0_12

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