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Biliary Excretion of Metals

  • Conference paper
Industrial and Environmental Xenobiotics

Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

Abstract

The main biochemical and physiological function traditionally attributed to bile is its role in fat digestion. Its excretory role has been of course recognized, but no greater importance has been ascribed to it than the elimination of few compounds of physiological interest. The excretory function of bile is, however, much wider. Many compounds arising from intermediary metabolism and variety of xenobiotics are excreted via bile (Smith 1973). A major reason why our knowledge of the biliary system had progressed so slowly was probably its relative inaccessibility. During the last decade, however, considerable information has been obtained on the biliary excretion of xenobiotics, and within the last few years some information on the biliary excretion of metals as well. A comprehensive summary of experimental data concerning the biliary excretion of xenobiotics has been reported by Smith (1973) and an excellent review on the biliary excretion of metals by Klaassen (1976). The main purpose of the present review is to summarize up-to-date information concerning biliary excretion of metals and to sketch at least broad outlines of the possible mechanisms involved in these processes.

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Author information

Authors and Affiliations

  1. Institute of Hygiene and Epidemiology, 100 42, Prague 10, Srobarova 48, Czechoslovakia

    M. Cikrt

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  1. M. Cikrt
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Editors and Affiliations

  1. Institute of Hygiene and Epidemiology, Šrobárova 48, 10042, Prague 10, Czechoslovakia

    Ivan Gut M.D., Ph.D.  & Miroslav Cikrt M.D., Ph.D.  & 

  2. Faculté des études supérieures, Université de Montréal, C.P. 6128, Succ. A, H3C3J7, Montréal, Québec, Canada

    Gabriel L. Plaa Ph.D.

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© 1981 Springer-Verlag Berlin Heidelberg

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Cikrt, M. (1981). Biliary Excretion of Metals. In: Gut, I., Cikrt, M., Plaa, G.L. (eds) Industrial and Environmental Xenobiotics. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68195-0_2

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  • DOI: https://doi.org/10.1007/978-3-642-68195-0_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-68197-4

  • Online ISBN: 978-3-642-68195-0

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