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Diffusible Factors in Tissue Cultures

  • Chapter
Tissue Growth Factors

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 57))

Abstract

It is well known that cells of higher, multicellular organisms interact in a complex way compared with populations of unicellular organisms such as bacteria and protozoa.

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References

  • Abercrombie, M.: Contact-dependent behavior of normal cells and the possible significance of surface changes in virus-induced transformation. Cold Spring Harbor Symp. Quant. Biol. 27, 427–431 (1962).

    PubMed  CAS  Google Scholar 

  • Abercrombie, M.: Contact inhibition and malignancy. Nature 281, 259–262 (1979).

    Article  PubMed  CAS  Google Scholar 

  • Ames, B.N., Durston, W.E., Yamasaki, E., Lee, F.D.: Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection. Proc. Natl. Acad. Sci. U.S.A. 70, 2281–2285 (1973).

    Article  PubMed  CAS  Google Scholar 

  • Anderson, W.B., Wilson, J., Rechler, M.M., Nissley, S.P.: Effect of multiplication stimulating activity (MSA) on intracellular cAMP levels and adenylate cyclase activity in chick embryo fibroblasts. Exp. Cell Res. 120, 47–53 (1979).

    Article  PubMed  CAS  Google Scholar 

  • Azarnia, R., Michalke, W., Loewenstein, W.R.: Intercellular communication and tissue growth. VI-Failure of exchange of endogenous molecules between cancer cells with defective functions and uncancerous cells. J. Membr. Biol. 10, 247–258 (1972).

    Article  PubMed  CAS  Google Scholar 

  • Benedetti, E.L., Dunia, I., Bentzel, C.J., Vermorken, A.J., Kibbelaar, M., Bloemendal, H.: A portrait of plasma membrane specializations in eye lens epithelium and fibers. Biochim. Biophys. Acta 457, 353–384 (1976).

    Article  PubMed  CAS  Google Scholar 

  • Bird, M.M., James, D.W.: The culture of previously dissociated embryonic chick spinal cord cells on feeder layers of liver and kidney and the development of paraformaldehyde induced fluorescence upon the former. J. Neurocytl. 4, 633–646 (1975).

    Article  CAS  Google Scholar 

  • Blade, E., Harel, L., Hanania, N.: Variation du taux d’incorporation du phosphore dans les cellules en fonction de leurs concentrations et inhibition de contact. Exp. Cell Res. 41, 473–482 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Bols, N.C., Ringertz, N.R.: A study of metabolic cooperation with established myoblast cell lines. Exp. Cell Res. 120, 15–23 (1979).

    Article  PubMed  CAS  Google Scholar 

  • Böse, S.K., Zlotnick, B.: Growth and density dependent inhibition of deoxyglucose transport in Balb/3 T 3 cells and its absence in cells transformed by murine sarcoma virus. Proc. Natl. Acad. Sci. U.S.A. 70, 2374–2378 (1973).

    Article  PubMed  Google Scholar 

  • Burk, R.R.: A factor from a transformed cell line that affects cell migration. Proc. Natl. Acad. Sci. U.S.A. 70, 369–372 (1973).

    Article  PubMed  CAS  Google Scholar 

  • Burk, R.R., Pitts, J.D., Subak-Sharpe, J.H.: Exchange between hamster cells in culture. Exp. Cell Res. 55, 297–301 (1968).

    Google Scholar 

  • Canagaratna, M.C., Riley, P.A.: The pattern of density dependant growth inhibition in murine fibroblasts. J. Cell. Physiol. 85, 271–281 (1975).

    Article  PubMed  CAS  Google Scholar 

  • Canagaratna, M.C.P., Chapman, R., Ehrlich, E., Sutton, P.M., Riley, P.A.: Evidence for long-range effects in density-dependent inhibition of proliferation. Differentiation 9, 157–160 (1977).

    Article  Google Scholar 

  • Caspar, D.L.D., Goodenough, D.A., Makowski, L., Phillips, W.C.: Gap junction structures. Correlated electron microscopy and X-ray diffraction. J. Cell. Biol. 74, 605–628 (1977).

    Article  PubMed  CAS  Google Scholar 

  • Ceccarini, C., Eagle, H.: pH as a determinant of cellular growth and contact inhibition. Proc. Natl. Acad. Sci. U.S.A. 68, 229–233 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Chang, C, Simmons, D.T., Martin, M.A., Mora, P.T.: Identification and partial characterization of new antigens from Simian virus 40-transformed mouse cells. J. Virol. 31, 463–471 (1979).

    PubMed  CAS  Google Scholar 

  • Chapman, R.E., Marsh, E., Sutton, P.M., Riley, P.A.: Studies of long range density effects in the proliferation of 3 T 3 and RLCW cells in recirculated medium. Differentiation 10, 159–164 (1978).

    Article  PubMed  CAS  Google Scholar 

  • Clarke, G.D., Stoker, M.G.P., Ludlow, A., Thornton, M.: Requirement of serum for DNA synthesis in BHK21 cells: effects of density, suspension and virus transformation. Nature 227, 798–801 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Corsaro, CM., Migeon, R.: Comparison of contact mediated communication in normal and transformed human cells in culture. Proc. Natl. Acad. Sci. U.S.A. 74, 4476–4480 (1977).

    Article  PubMed  CAS  Google Scholar 

  • Cox, R.P., Krauss, M.R., Balis, M.E., Dancis, J.: Evidence for transfer of enzyme product as the basis of metabolic cooperation between tissue culture fibroblasts of Lesch-Nylan disease and normal cells. Proc. Natl. Acad. Sci. U.S.A. 67, 1573–1579 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Cox, R.P., Krauss, M.R., Balis, M.E., Dancis, J.: Communication between normal and enzyme deficient cells in tissue culture. Exp. Cell Res. 74, 251–268 (1972).

    Article  PubMed  CAS  Google Scholar 

  • Cox, R.P., Krauss, M.R., Balis, M.E., Dancis, J.: Metabolic cooperation in cell culture: studies of the mechanism of cell interaction. J. Cell. Physiol. 84, 237–252 (1974).

    Article  PubMed  CAS  Google Scholar 

  • Cox, R.P., Krauss, M.R., Balis, M.E., Dancis, J.: Studies on cell communication with enucleated human fibroblasts. J. Cell. Biol. 71, 693–703 (1976).

    Article  PubMed  CAS  Google Scholar 

  • Cunningham, D.D., Pardee, A.B.: Transport changes rapidly initiated by serum addition to “contact inhibited” 3T3 cells. Proc. Natl. Acad. Sci. U.S.A. 64, 1049–1056 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Danes, B.S., Paul, J.: Environmental factors influencing respiration of L. cells strain. Exp. Cell Res. 24, 344–355 (1961).

    CAS  Google Scholar 

  • De Larco, J.E., Todaro, G.J.: Growth factors from murine sarcoma virus transformed cells. Proc. Natl. Acad. Sci. U.S.A. 75, 4001–4005 (1978).

    Article  PubMed  Google Scholar 

  • De Larco, J., Reynolds, R., Carlberg, K., Engle, C, Todaro, G.J.: Sarcoma growth factor (SGF) from mouse Sarcoma virus (MSV) transformed cells: purification by binding and elution from epidermal growth factor (EGF) receptor-rich cells. J. Biol. Chem. 255, 3685–3690 (1980).

    PubMed  Google Scholar 

  • De Leo, A.B., Jay, G., Appella, E., Dubois, G., Law, L.W., Old, L.J.: Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse. Proc. Natl. Acad. Sci. U.S.A. 76, 2420–2424 (1979).

    Article  Google Scholar 

  • Derr, J.T., Smith, G.L.: Regulation of amino acid transport in chicken embryo fibroblasts by purified Multiplication-stimulating activity (MSA). J. Cell. Physiol. 102, 55–62 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Dubrow, R., Pardee, A.B., Pollack, R.: 2-Amino-isobutyric acid and 3-O-methyl-D-glucose transport in 3T3, SV40-transformed 3T3 and revertant cell lines. J. Cell. Physiol. 95, 203–211 (1978).

    Article  PubMed  CAS  Google Scholar 

  • Dulak, N., Temin, H.M.: A partially purified Polypeptide fraction from rat liver cell conditioned medium with multiplication-stimulating activity for embryo fibroblasts. J. Cell. Physiol. 81, 153–160 (1973 a).

    Google Scholar 

  • Dulak, H., Temin, H.M.: Multiplication-stimulating activity for chicken embryo fibroblasts from rat liver cell conditioned medium: a family of small Polypeptides. J. Cell. Physiol. 81, 161–170 (1973 b).

    Google Scholar 

  • Dulbecco, R.: Topoinhibition and serum requirement of transformed and untransformed cells. Nature 227, 802–806 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Dulbecco, R., Elkington, J.: Conditions limiting multiplication of fibroblasts and epithelial cells in dense cultures. Nature 246, 197–199 (1973).

    Article  PubMed  CAS  Google Scholar 

  • Dulbecco, R., Stoker, M.G.: Conditions determining initiation of DNA synthesis in 3T3 cells. Proc. Natl. Acad. Sci. U.S.A. 66, 204–210 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Eagle, H.: Metabolic controls in cultured mammalian cells. Science 148, 42–51 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Eagle, H., Piez, K.: The population-dependent requirement by cultured mammalian cells for metabolites which they can synthesize. J. Exp. Med. 116, 29–43 (1962).

    Article  PubMed  CAS  Google Scholar 

  • Earle, W.R., Sanford, K.K., Evans, V.J., Waltz, H.K., Shannon, J.E.: The influence of inoculum size on proliferation in tissue cultures. J. Natl. Cancer Inst. 12, 133–153 (1951).

    PubMed  CAS  Google Scholar 

  • Ehrhart, J.C., Chauveau, J.: The protein component of mouse-hepatocyte gap junctions. FEBS Letters 78, 295–299 (1977).

    Article  PubMed  CAS  Google Scholar 

  • Epstein, A.L., Kaplan, H.S.: Feeder layer and nutritional requirements for the establishment and cloning of human malignant lymphoma cell lines. Cancer Res. 39, 1748–1759 (1979).

    PubMed  CAS  Google Scholar 

  • Fisher, H.W., Puck, T.T.: On the functions of X-irradiated “feeder” cells in supporting growth of single mammalian cells. Proc. Natl. Acad. Sci. U.S.A. 42, 900–906 (1956).

    Article  PubMed  CAS  Google Scholar 

  • Fodge, D.W., Rubin, H.: Glucose utilization, pH reduction and density dependent inhibition in cultures of chick embryo fibroblasts. J. Cell. Physiol. 85, 635–642 (1975).

    Article  PubMed  CAS  Google Scholar 

  • Folkman, J., Moscona, A.: Role of cell shape in growth control. Nature 273, 345–349 (1978).

    Article  PubMed  CAS  Google Scholar 

  • Froehlich, J.E., Anastassiades, T.P.: Role of pH in fibroblast proliferation. J. Cell. Physiol. 84, 253–260 (1974).

    Article  PubMed  CAS  Google Scholar 

  • Froehlich, J.E., Anastassiades, T.P.: Possible limitation of growth in human fibroblast cultures by diffusion. J. Cell. Physiol. 86, 567–580 (1975).

    Article  PubMed  Google Scholar 

  • Froese, G.: Regulation of growth in Chinese hamster cells by a local inhibitor. Exp. Cell. Res. 65, 297–306 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Fujimoto, W.Y., Subak-Sharpe, J.H., Seegmiller, J.E.: Hypoxanthine-guanine Phosphori-bosyl-transferase deficiency chemical agents selective for mutant or normal cultures fibroblasts in mixed and heterozygote cultures. Proc. Natl. Acad. Sci. U.S.A. 68, 1516–1519 (1971).

    Google Scholar 

  • Garcia Giralt, E., Berumen, L., Macieira-Coelho, A.: Growth inhibitory activity in the supernatants of nondividing W138 cells. J. Natl. Cancer Inst. 45, 649–655 (1970).

    PubMed  CAS  Google Scholar 

  • Gaudray, P., Rassoulzadegan, M., Cuzin, F.: Expression of simian virus early genes in transformed rat cells is correlated with maintenance of the transformed phenotype. Proc. Natl. Acad. Sci. U.S.A. 75, 4987–4991 (1978).

    Article  PubMed  CAS  Google Scholar 

  • Gilula, N.B., Reeves, O.R., Steinbach, A.: Metabolic coupling ionic coupling and cell contacts. Nature 235, 262–265 (1972).

    Article  PubMed  CAS  Google Scholar 

  • Golde, A.: Chemical changes in chick embryo cells infected with Rous Sarcoma virus. Virology 16, 9–20 (1962).

    Article  CAS  Google Scholar 

  • Gottesman, M.M.: Transformation-dependent secretion of a low molecular weight protein by murine fibroblasts. Proc. Natl. Acad. Sci. U.S.A. 75, 2767–2771 (1978).

    Article  PubMed  CAS  Google Scholar 

  • Graves, J.A.: Use of enzyme — deficient cell lines as feeder layers. In Vitro 14, 506–509 (1978).

    Article  PubMed  CAS  Google Scholar 

  • Grogan, E.A., Enders, J.F., Miller, G.: Trypsinized placental cell cultures for the propagation of viruses and as “feeder-layers”. J. Virol. 5, 406–409 (1970).

    PubMed  CAS  Google Scholar 

  • Harel, L., Jullien, M.: Relation between the rate of phosphate uptake or DNA synthesis and the mean intercellular distance in mouse and hamster cell cultures. J. Microsc. Biol. Cell. 26, 75–78 (1976a).

    CAS  Google Scholar 

  • Harel, L., Jullien, M.: Evaluation of proximity inhibition of DNA synthesis in 3T3 cells. J. Cell. Physiol. 88, 253–254 (1976b).

    Article  PubMed  CAS  Google Scholar 

  • Harel, L., Jullien, M., Blat, C: Control by cell interaction of phosphate uptake in 3 T 3 cells. Exp. Cell. Res. 90, 201–210 (1975).

    Article  PubMed  CAS  Google Scholar 

  • Harel, L., Jullien, M., De Monti, M.: Diffusible factor(s) controlling density inhibition of 3T3 cells growth: a new approach. J. Cell. Physiol. 96, 327–332 (1978).

    Article  PubMed  CAS  Google Scholar 

  • Henderson, D., Eibl, M., Weber, K.: Structure and Biochemistry of mouse hepatic gap. junctions. J. Mol. Biol. 132, 193–218 (1979).

    Article  CAS  Google Scholar 

  • Holley, R.W.: A unifying hypothesis concerning the nature of malignant growth. Proc. Natl. Acad. Sci. U.S.A. 69, 2840–2841 (1972).

    Article  PubMed  CAS  Google Scholar 

  • Holley, R.W.: Control of growth of mammalian cells in cell culture. Nature 258, 487–490 (1975).

    Article  PubMed  CAS  Google Scholar 

  • Holley, R.W.: Control of growth of kidney epithelial cells in: Control mechanisms in cultured animal cells. Ed. by: Shields, R., Levi-Montalcini, R., Iacobelli, S., Jimenez Dearua, L.: Sous Presse 1980.

    Google Scholar 

  • Holley, R.W., Baldwin, J.H.: Cell density is determined by a diffusion-limited process. Nature 278, 283–284 (1979).

    Article  PubMed  CAS  Google Scholar 

  • Holley, R.W., Armour, R., Baldwin, J.H., Brown, K.D., Yeh, Y.C.: Density-dependent regulation of growth of BSC1 cells in cell culture. Control of growth by serum factors. Proc. Natl. Acad. Sci. U.S.A. 74, 5046–5050 (1977).

    Article  PubMed  CAS  Google Scholar 

  • Holley, R.W., Armour, R., Baldwin, J.H.: Density-dependent regulation of growth of BSC-1 cells in cell culture: growth inhibitors formed by the cells. Proc. Natl. Acad. Sci. U.S.A. 75, 1864–1866 (1978).

    Article  PubMed  CAS  Google Scholar 

  • Houck, J.C., Weil, R.L., Sharma, V.K.: Evidence for a fibroblast chalone. Nature New Biol. 240, 210–211 (1972).

    Google Scholar 

  • Huberman, E., Sachs, L.: Mutability of different genetic loci in mammalian cells by metabolically activated carcinogenic polycyclic hydrocarbons. Proc. Natl. Acad. Sci. U.S.A. 73, 188–192 (1976).

    Article  PubMed  CAS  Google Scholar 

  • Jullien, M., Harel, L.: Stimulation by serum of the phosphorylation reactions in density-inhibited 3T3 cells. Exp. Cell. Res. 97, 23–30 (1976).

    Article  PubMed  CAS  Google Scholar 

  • Kelley, R.O., Vogel, K.G., Crissman, H.A., Lujan, C.J., Skipper, B.E.: Development of the aging cell surface. Exp. Cell. Res. 119, 127–143 (1979).

    Article  PubMed  CAS  Google Scholar 

  • Kieler, J.: Influence of CO2 tension on the respiration of Yoshida ascites tumor cells. J. Natl. Cancer Inst. 25, 161–176 (1960).

    PubMed  CAS  Google Scholar 

  • Kirkland, W., Yang, N.S., Jorgensen, T., Longley, C., Furmanski, P.: Growth of normal and malignant human mammary epithelial cells in culture. J. Natl. Cancer Inst. 63, 29–39 (1979).

    PubMed  CAS  Google Scholar 

  • Knauer, D.J., Smith, G.L.: Regulation of the proliferative response in Rous Sarcoma virus transformed chickens embryo fibroblasts by serum and multiplication-stimulating activity (MSA). J. Cell. Physiol. 100, 311–322 (1979).

    Article  PubMed  CAS  Google Scholar 

  • Knecht, M.E., Lipkin, G.: Biochemical studies of a protein which restores contact inhibition of growth to malignant melanocytes. Exp. Cell. Res. 108, 15–22 (1977).

    PubMed  CAS  Google Scholar 

  • Kress, M., May, E., Cassingena, R., May, P.: Simian virus 40-transformed cells express new species of protein precipitable by anti-simian virus 40 tumor serum. J. Virol. 31, 472–483 (1979).

    PubMed  CAS  Google Scholar 

  • Kryceve, C, Vigier, P., Barlati, S.: Transformation-enhancing factor(s) produced by virus-transformed and established cells. Int. J. Cancer 17, 370–379 (1976).

    Article  PubMed  CAS  Google Scholar 

  • Langenbach, R., Freed, HJ., Huberman, E.: Liver cell-mediated mutagenesis of mammalian cells by liver carcinogens. Proc. Natl. Acad. Sci. U.S.A. 75, 2564–2867 (1978).

    Article  Google Scholar 

  • Ledbetter, M.L., Lubin, M.: Transfert of potassium. A new measure of cell-cell coupling. J. Cell Biol. 80, 150–165 (1979).

    Article  PubMed  CAS  Google Scholar 

  • Levine, E.M., Becker, Y., Brooke, C.B., Eagle, H.: Contact inhibition, macromolecular synthesis and polyribosomes in cultured human diploid fibroblasts. Proc. Natl. Acad. Sci. U.S.A. 55, 350–356 (1965).

    Google Scholar 

  • Likely, G.D., Sanford, K.K., Earle, W.R.: Further studies on the proliferation in vitro of single isolated tissue cells. J. Natl. Cancer Inst. 13, 177–187 (1952).

    PubMed  CAS  Google Scholar 

  • Lipkin, G., Knecht, M.: A diffusible factor restoring contact inhibition of growth to malignant melanocytes. Proc. Natl. Acad. Sci. U.S.A. 71, 849–853 (1974).

    Article  PubMed  CAS  Google Scholar 

  • Lipkin, G., Knecht, M.E.: Restoring contact inhibition of growth to malignant melanocytes of man, mouse, and hamster. Schweiz. Med. Wochenschr. 105, 1360–1364 (1975).

    PubMed  CAS  Google Scholar 

  • Lipkin, G., Knecht, M.E.: Contact inhibition of growth is restored to malignant melanocytes of man and mouse by a hamster protein. Exp. Cell Res. 102, 341–348 (1976).

    Article  PubMed  CAS  Google Scholar 

  • Lipkin, G., Knecht, M.E., Rosenberg, M.: A potent inhibitor or normal and transformed cell growth derived from contact-inhibited cells. Cancer Res. 38, 635–643 (1978).

    PubMed  CAS  Google Scholar 

  • Maclntyre, E., Ponten, J.: Interaction between normal and transformed bovine Fibroblast in culture I-Cells transformed by Rous Sarcoma virus. J. Cell Sci. 2, 309–322 (1967).

    Google Scholar 

  • Malmquist, W.A., Brown, C.G.: Establishment of Theileria parva infected lymphoblastoid cell lines using homologous feeder layers. Res. Vet. Sci. 16, 134–135 (1974).

    PubMed  CAS  Google Scholar 

  • Marty de Morales, M., Blat, C., Harel, L.: Changes in the phosphorylation of non-histone chromosomal proteins in relationship to DNA and RNA synthesis in BHK2iC13 cells. Exp. Cell Res. 86, 111–119 (1974).

    Article  CAS  Google Scholar 

  • Martz, E., Steinberg, H.S.: The role of cell-cell contact in “contact” inhibition of cell division: a review and new evidence. J. Cell. Physiol. 79, 189–210 (1972).

    Article  PubMed  CAS  Google Scholar 

  • Megyesi, K., Kahn, CR., Roth, J.: The NSILA-s receptor in liver plasma membranes: characterization and comparison with the insulin receptor. J. Biol. Chem. 250, 8990–8996 (1976).

    Google Scholar 

  • Merrill, G.F., Florini, J.R., Dulak, N.C.: Effects of multiplication stimulating activity (MSA) on AIB transport into myoblast and myotube cultures. J. Cell. Physiol. 93, 173–182 (1977).

    Article  PubMed  CAS  Google Scholar 

  • Merrill, G.F., Dulak, N.C., Florini, J.R.: MSA stimulation of AIB transport is dependent of K+ accumulation in myoblasts. J. Cell. Physiol. 100, 343–350 (1979).

    Article  PubMed  CAS  Google Scholar 

  • Mondai, S., Lillehaug, J.R., Heidelberger, C: Cell mediated activation of aflatoxin-B 1 to transform C3H/10 T 1/2 cells. Proc. A. A. C.R. Abstract 20, 62 (1979).

    Google Scholar 

  • Moses, A.C., Nissley, S.P., Short, P.A., Rechler, M.M., Podskalny, J.M.: Purification and characterization of multiplication stimulating activity (MSA): insulin-like growth factors purified from rat liver cell conditioned media. Eur. J. Biochem. 103, 387–400 (1980a).

    Article  PubMed  CAS  Google Scholar 

  • Moses, A.C., Nissley, S.P., Short, P.A., Rechler, M.M.: Immunological cross-reactivity of multiplication stimulating activity (MSA) Polypeptides. Eur. J. Biochem. 103, 401–408 (1980b).

    Article  PubMed  CAS  Google Scholar 

  • Murray, A., Fitzgerald, D.J.: Tumor promoters inhibit metabolic cooperation in cocultures of epidermal and 3T3 cells. Biochem. Biophys. Res. Commun. 91, 395–401 (1979).

    Article  PubMed  CAS  Google Scholar 

  • Natraj, C.V., Datta, P.: Control of DNA synthesis in growing BALB/c 3 T 3 mouse cells by a fibroblast growth regulatory factor. Proc. Natl. Acad. Sei. U.S.A. 75, 6115–6119 (1978).

    Article  CAS  Google Scholar 

  • Nicolas, J.F., Jacob, M., Jacob, F.: Metabolic cooperation between mouse embryonal carcinoma cells and their differentiated derivatives. Proc. Natl. Acad. Sci. U.S.A. 75, 3293–3296 (1978).

    Article  Google Scholar 

  • Nissley, S.P., Rechter, M.M.: Multiplication-stimulating activity (MSA): a somatomedin-like Polypeptide from cultured rat liver cells. Natl. Cancer Inst. Monogr. 48, 167–177 (1978).

    PubMed  Google Scholar 

  • Nissley, S.P., Passamani, J., Short, P.: Stimulation of DNA synthesis, cell multiplication and Ornithine decarboxylase in 3 T 3 cells by multiplication-stimulating activity (MSA). J. Cell. Physiol. 89, 393–402 (1976).

    Article  PubMed  CAS  Google Scholar 

  • Nissley, S.P., Short, P.A., Rechler, M.M., Podskalny, J.N., Coon, H.G.: Proliferation of Buffalo rat liver cells in serumfree medium does not depend upon multiplication-stimulating activity (MSA). Cell 11, 441–446 (1977).

    Article  PubMed  CAS  Google Scholar 

  • Nordenskjold, B.A., Skoog, L., Brown, M.C., Reichard, P.: Deoxyribonucleotide pools and deoxyribonucleic acid synthesis in cultured mouse embryo cells. J. Biol. Chem. 245, 5360–5368 (1970).

    PubMed  CAS  Google Scholar 

  • Okuda, A., Kimura, G.: Serum stimulation of DNA synthesis in rat 3 Y 1 cells. Dependence on cell density, serum concentration and ratio of cell number to medium volume. Exp. Cell. Res. 111, 55–62 (1978).

    Article  PubMed  CAS  Google Scholar 

  • Oshima, R.: Stimulation of the clonal growth and differentiation of feeder layer dependent mouse embryonal carcinoma cells by β-mercaptoethanol. Differentiation 11, 149–155 (1978).

    Article  PubMed  CAS  Google Scholar 

  • Pardee, A.: Cell division and a hypothesis of cancer. Natl. Cancer Inst. Monogr. 14, 7–18 (1964).

    PubMed  CAS  Google Scholar 

  • Pardee, A.B.: The cell surface and flbroblast proliferation. Some current research trends. Biochim. Biophys. Acta 417, 153–172 (1975).

    PubMed  CAS  Google Scholar 

  • Pariser, R.P., Cunningham, D.D.: Transport inhibitors released by 3T3 mouse cells and their relation to growth control. J. Cell Biol. 49, 525–529 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Perry, W.P., Sanford, K.K., Evans, V.J., Hyatt, G.W., Earle, W.R.: Establishment of clones of epithelial cells from human skin. J. Natl. Cancer Inst. 18, 709–713 (1957).

    PubMed  CAS  Google Scholar 

  • Pierson, R.W., Temin, H.M.: The partial purification from calf serum of a fraction with multiplication-stimulating activity for chicken flbroblasts in cell culture and with non-suppressible insulin-like activity. J. Cell. Physiol. 79, 319–330 (1972).

    Article  PubMed  CAS  Google Scholar 

  • Pitts, J.D., Finbow, M.E.: Functional permeability and its consequences. in: Intercellular communication. Mello, W.C. de (ed.), pp. 61–86. New York: Plenum 1977.

    Google Scholar 

  • Pitts, J.D., Simms, J.W.: Permeability of junctions between animal cells. Exp. Cell Res. 104, 153–163 (1977).

    Article  PubMed  CAS  Google Scholar 

  • Pope, J.H., Scott, W., Moss, D.J.: Cell relationships in transformation of human leukocytes by Epstein-Barr virus. Int. J. Cancer 14, 122–129 (1974).

    Article  PubMed  CAS  Google Scholar 

  • Puck, T.T., Marcus, P.I.: A rapid method for viable cell titration and clone production with HeLa cells in tissue culture: the use of X-irradiated cells to supply conditioning factors. Proc. Natl. Acad. Sci. U.S.A. 41, 432–437 (1955).

    Article  PubMed  CAS  Google Scholar 

  • Rapp, F., Westmoreland, D.: Cell transformation by DNA-containing viruses. Biochim. Biophys. Acta 458, 167–211 (1976).

    PubMed  CAS  Google Scholar 

  • Rechler, M.M., Podskalny, J.M.: Insulin receptors in cultured human flbroblasts. Diabetes 25, 250–255 (1976).

    Article  PubMed  CAS  Google Scholar 

  • Rechler, M.M., Podskalny, J.M., Nissley, S.P.: Characterization of the binding of multiplication stimulating activity to a receptor for growth Polypeptides in chick embryo flbroblasts. J. Biol. Chem. 252, 3898–3910 (1977 a).

    Google Scholar 

  • Rechler, M.M., Nissley, S.P., Podskalny, J.M. et al: Identification of a receptor for somatomedin-like Polypeptides in human flbroblasts. J. Clin. Endocrinol. Metab. 44, 820–831 (1977 b).

    Google Scholar 

  • Rein, A., Rubin, H.: On the survival of chick embryo cells at low concentrations in culture. Exp. Cell. Res. 65, 209–214 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Sakiyama, H., Terasima, T., Sato, K.: Effects of confluent monolayers of density-inhibited and transformed cells on the growth of superinoculated cells. Cancer Res. 38, 2854–2858 (1978).

    PubMed  CAS  Google Scholar 

  • Sanford, K.K., Earle, W.R., Likely, G.D.: The growth in vitro of single isolated tissue cells. J. Natl. Cancer Inst. 9, 229–246 (1948).

    PubMed  CAS  Google Scholar 

  • Schneider, U., Zur Hausen, H.: Epstein-Barr virus-induced transformation of human leukocytes after cell fractionation. Int. J. Cancer 15, 59–66 (1975).

    Article  PubMed  CAS  Google Scholar 

  • Senger, D.R., Wirth, D.F., Hynes, R.O.: Transformed mammalian cells secrete specific proteins and phosphoproteins. Cell 16, 885–893 (1979).

    Article  PubMed  CAS  Google Scholar 

  • Sheridan, J.D., Finbow, M.E., Pitts, J.D.: Metabolic cooperation in culture: possible involvement of junctional transfer in regulation of enzyme activities. J. Cell Biol. 67, 396 a (1975).

    Google Scholar 

  • Sheridan, J., Finbow, M.E., Pitts, J.D.: Metabolic interactions between animal cells through permeable intercellular junctions. Exp. Cell Res. 123, 111–117 (1979).

    Article  PubMed  CAS  Google Scholar 

  • Slack, C, Morgan, R.H.M., Hooper, M.L.: Isolation of metabolic cooperation-defective variants from mouse embryonal carcinoma cells. Exp. Cell Res. 117, 195–205 (1978).

    Article  PubMed  CAS  Google Scholar 

  • Smith, G.L.: Increased ouabain-sensitive 86Rubidium uptake after mitogenic stimulation of quiescent chicken embryo fibroblasts with purified multiplication-stimulating activity. J. Cell Biol. 73, 761–767 (1977).

    Article  PubMed  CAS  Google Scholar 

  • Smith, G.L., Temin, H.M.: Purified multiplication-stimulating activity from rat liver conditioned medium: comparison of biological activities with calf serum. J. Cell. Physiol. 84, 181–192 (1974).

    Article  PubMed  CAS  Google Scholar 

  • Steck, P.A., Voss, P.G., Wang, J.L.: Growth control in cultured 3T3 fibroblasts. Assays of cell proliferation and demonstration of a growth inhibiting activity. J. Cell Biol. 83, 562–575 (1979).

    Article  PubMed  CAS  Google Scholar 

  • Stoker, M.: Contact and short-range interactions affecting growth of animal cells in culture. Curr. Top. Dev. Biol. 2, 107–128 (1967a).

    Article  PubMed  CAS  Google Scholar 

  • Stoker, M.G.P.: Transfer of growth inhibition between normal and virus-transformed cells: autoradiographic studies using marked cells. J. Cell Sci. 2, 293–304 (1967b).

    PubMed  CAS  Google Scholar 

  • Stoker, M.G.P.: Role of diffusion boundary layer in contact inhibition of growth. Nature 246, 200–203 (1973).

    Article  PubMed  CAS  Google Scholar 

  • Stoker, M.G.P.: The effects of topoinhibition and cytochalasin B on etabolic cooperation. Cell 6, 253–257 (1975).

    Article  PubMed  CAS  Google Scholar 

  • Stoker, M.G.P., MacPherson, I.: Studies on transformation of hamster cells by polyoma virus in vitro. Virology 14, 359–370 (1961).

    Article  Google Scholar 

  • Stoker, M.G.P., Piggott, D.: Shaking 3T3 cells: further studies on diffusion boundary effects. Cell J, 207–215 (1974).

    Google Scholar 

  • Stoker, M.G.P., Sussman, M.: Studies on the action of feeder layers in cell culture. Exp. Cell. Res. 38, 645–653 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Stoker, M.G.P., Shearer, M., O’Neill, C: Growth inhibition of polyoma-transformed cells by contact with static normal fibroblasts. J. Cell Sci. 1, 297–310 (1966).

    PubMed  CAS  Google Scholar 

  • Subak-Sharpe, J.H.: Biochemically marked variants of the Syrian hamster fibroblast cell line BHK21 and its derivatives. Exp. Cell Res. 38, 106–119 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Subak-Sharpe, J.H., Burk, R.R., Pitts, J.D., May, J.: Metabolic cooperation by cell to cell transfer between genetically different mammalian cells in tissue culture. Heredity 21, 342–343 (1966).

    Google Scholar 

  • Subak-Sharpe, H., Burk, R.R., Pitts, J.D.: Metabolic cooperation between biochemically marked mammalian cells in tissue culture. J. Cell Sci. 4, 353–367 (1969).

    PubMed  CAS  Google Scholar 

  • Swann, M.M.: The control of cell division: a review I — General mechanisms. Cancer Res. 17, 727–758 (1957).

    PubMed  CAS  Google Scholar 

  • Taylor-Papadimitriou, J., Shearer, M., Waiting, D.: Growth requirements of calf lens epithelium in culture. J. Cell. Physiol. 95, 95–103 (1978).

    Article  PubMed  CAS  Google Scholar 

  • Temin, H.M.: Control of multiplication of uninfected rat cells and rat cells converted by murine Sarcoma virus. J. Cell. Physiol. 75, 107–120 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Todaro, G.J., Green, H.: Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. J. Cell Biol. 17, 299–313 (1963).

    Article  PubMed  CAS  Google Scholar 

  • Todaro, G.J., Lazar, G.K., Green, H.: The initiation of cell division in a contact-inhibited mammalian cell line. J. Cell. Physiol. 66, 325–334 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Van der Bosch, J., Maier, H.: Density-dependent growth inhibiting interactions between 3T3 and SV40-3T3 cells in mixed cultures. Z. Naturforsch. 34, 272–278 (1979).

    Google Scholar 

  • Vogt, M., Dulbecco, R.: Virus-cell interaction with a tumor-producing virus. Proc. Natl. Acad. Sci. U.S.A. 46, 365–370 (1960).

    Article  PubMed  CAS  Google Scholar 

  • Weiss, L., Poste, G., Mac Kearnin, A., Willett, K.: Growth of mammalian cells on substrates coated with cellular micro exudates. I. Effect on cell growth at low population densities. J. Cell Biol. 64, 135–145 (1975).

    Article  PubMed  CAS  Google Scholar 

  • Whitfield, J.G., Rixon, R.H.: The effect of dilution and carbon dioxide on the metabolic properties of suspension cultures of strain L mouse cells. Exp. Cell Res. 24, 177–180 (1961).

    Article  PubMed  CAS  Google Scholar 

  • Whittenberger, B., Glaser, L.: Inhibition of DNA synthesis in cultures of 3T3 cells by isolated surface membranes. Proc. Natl. Acad. Sci. U.S.A. 74, 2251–2255 (1977).

    Article  PubMed  CAS  Google Scholar 

  • Whittenberger, B., Glaser, L.: Cell saturation density is not determined by a diffusion-limited process. Nature 272, 821–823 (1978).

    Article  PubMed  CAS  Google Scholar 

  • Winger, L.A., Nowel, P.C., Daniele, R.P.: Sequential proliferation induced in human peripheral blood lymphocytes by mitogen-1. growth of 1000 lymphocytes in Feeder layer cultures. J. Immunol. 118, 1763–1767 (1977).

    PubMed  CAS  Google Scholar 

  • Wright, E.D., Slack, C., Goldfarb, P.S.G., Subak-Sharpe, J.H.: Investigation of the basis of reduced metabolic cooperation in MEC-cells. Exp. Cell Res. 103, 79–91 (1976 a).

    Google Scholar 

  • Wright, E.D., Goldfarb, P.S.G., Subak-Sharpe, J.H.: Isolation of variant cells with defective metabolic cooperation (MEC) from polyome virus transformed Syrian hamster cells. Exp. Cell Res. 103, 63–77 (1976 b).

    Google Scholar 

  • Yeh, J., Fisher, H.W.: A diffusible factor which sustains contact inhibition of replication. J. Cell Biol. 40, 382–388 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Zoref, E., De Vries, A., Sperling, O.: Transfer of resistance to selective conditions from fi-broblasts with mutant feedback-resistant phosphoribosyl pyrophosphate synthetase to normal cells. A form of metabolic cooperation. Adv. Exp. Med. Biol. 76 A, 80–84 (1977).

    Google Scholar 

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© 1981 Springer-Verlag Berlin Heidelberg

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Harel, L. (1981). Diffusible Factors in Tissue Cultures. In: Baserga, R. (eds) Tissue Growth Factors. Handbook of Experimental Pharmacology, vol 57. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67986-5_11

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