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Regulation of Human T-Cell Proliferation: T-Cell Growth Factor and Isolation of a New Class of Type-C Retroviruses from Human T-Cells

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Modern Trends in Human Leukemia IV

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 26))

Summary

The discovery, characterization, and purification of human T-cell growth factor (TCGF) has led to the establishment of continuously growing T-lymphoblast cell lines from normal people and from patients with certain T-cell neoplasias. In contrast to normal T-cells, neoplastic mature T-cells respond directly to TCGF, requiring no prior lectin or antigen in vitro activation. The transformed T-cell lines have phenotypic characteristics consistent with the neoplastic cells of their disease of origin. A novel retrovirus, human T-cell lymphomaleukemia virus (HTLV), has been isolated from the fresh and cultured cells of two of these patients. Subsequent characterization of this virus has shown that it is not significantly related to any known animal retrovirus, is not an endogenous (genetically transmitted) virus of man, and so far has been associated only with fresh or cultured T-cells from patients with T-cell neoplasia. These results suggest that HTLV infected some mature T-cells of some people and that it might be involved in some neoplasias involving these cells.

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Authors
  1. R. C. Gallo
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  2. B. J. Poiesz
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  3. F. W. Ruscetti
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Editor information

Editors and Affiliations

  1. Molekularbiologisch-hämatologische Arbeitsgruppe, Universitäts-Kinderklinik, Martinistraße 52, D-2000, Hamburg 20, Federal Republic of Germany

    Rolf Neth

  2. Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland, 20014, USA

    Robert C. Gallo

  3. Institut für Virusforschung, Im Neuenheimer Feld 280, D-6900, Heidelberg 1, Federal Republic of Germany

    Thomas Graf

  4. Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie an der Universität Hamburg, Martinistraße 52, D-2000, Hamburg 20, Federal Republic of Germany

    Klaus Mannweiler

  5. Abteilung für Haematologie und Onkologie, Universitäts-Kinderklinik, Martinistr. 52, D-2000, Hamburg 20, Federal Republic of Germany

    Kurt Winkler

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© 1981 Springer-Verlag Berlin Heidelberg

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Gallo, R.C., Poiesz, B.J., Ruscetti, F.W. (1981). Regulation of Human T-Cell Proliferation: T-Cell Growth Factor and Isolation of a New Class of Type-C Retroviruses from Human T-Cells. In: Neth, R., Gallo, R.C., Graf, T., Mannweiler, K., Winkler, K. (eds) Modern Trends in Human Leukemia IV. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 26. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67984-1_93

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  • DOI: https://doi.org/10.1007/978-3-642-67984-1_93

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-10622-7

  • Online ISBN: 978-3-642-67984-1

  • eBook Packages: Springer Book Archive

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