Abstract
Chronic myelogenous leukemias have arisen a considerable new interest, since lymphoblastic crises recently turned out to complicate and terminate a primary myeloproliferative disease (Beard et al., 1976; Janossy et al., 1977; Rosenthal et al., 1977). Ways of stem cell differentiation (Metcalf, 1973, 1974, 1977; Boggs, 1974; Moore, 1976; Greenberg, 1976, 1978) as well as biological markers of leukemic cells (Fialkow et al., 1977, 1978a, b) give sufficient proof for the suggestion that hematopoietic stem cells have been primarily involved in this disease.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Alimena, G., Annino, L., Balestrazzi, P., Montuoro, A., Dallapiccola, B.: Cytogenetic studies in acute leukaemias. Prognostic implications of chromosome imbalances. Acta Haematol. 58, 234–239 (1977)
Bain. B., Catovsky, C., O’Brien, M., Spiers, A.S.D., Richards, H.G. H.: Megakaryoblastic transformation of chronic granulocytic leukaemia. J. Clin. Pathol. 30, 235–242 (1977)
Beard, M.E.J., Durrant, J., Catovsky, D., Wiltshaw, E., Amess, J.L., Brearley, R.L., Kirk, B., Wrigley, P.F.M., Janossy, G., Greaves, M.F., Galton, D.A.G.: Blast crisis of chronic myeloid leukaemia (CML). Br. J. Haematol. 34, 167–178 (1976)
Bennett, J.M., Reed, C.E.: Acute leukemia. Cytochemical profile: Diagnostic and clinical implications. Blood Cells 1, 101–108 (1975)
Bennett, J.M., Catovsky, D., Daniel, M.T., et al.: Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group. Br. J. Haematol. 33, 551–558 (1976)
Bessis, M.: Living blood cells and their ultrastructure. Berlin, Heidelberg, New York: Springer 1973
Bessis, M.: Pathology of the leukemic cell or reasons why some leukemias are unclassifiable. Blood Cells 1, 183–188 (1975)
Boggs, D. R.: Hematopoetie stem cell theory in relation to possible lymphoblastic conversion of chronic myeloid leukemia. Blood 44, 449–453 (1974)
Burkhardt, R.: Präparative Voraussetzungen zur klinischen Histologic des menschlichen Knochenmarkes. Blut 14, 30–46 (1966a)
Burkhardt, R.: Technische Verbesserungen und Anwendungsbereich der Histo-Biopsie von Knochenmark und Knochen. Klin. Wochenschr. 44, 326–334 (1966b)
Burkhardt, R.: Bone marrow and bone tissue. Berlin, Heidelberg, New York: Springer 1971
Buyssens, N., Bourgeois, N.H.: Chronic myelocytic leukemia versus idiopathic myelofibrosis: A diagnostic problem in bone marrow biopsies. Cancer 40, 1548–1561 (1977)
Catovsky, D., Costello, C., O’Brien, M., Cherchi, M.: Ultrastructural and cell marker studies in lymphoproliferative disorders. In: Modern Trends in Leukemia III. R. Neth, P.-H. Hofschneider, K. Mannweiler (eds.). Berlin, Heidelberg, New York: Springer 1978
Catovsky, D., Galton, D.A.G.: Cell markers and the classification of acute leukaemia., 1978. In press
Fialkow, P.J., Jacobson, R.J., Papayannopoulou, T.: Chronic myelotic leukemia: Clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage. Am. J. Med. 63, 125–130 (1977)
Fialkow, P.J., Denman, A.M., Jacobson, R.J., Lowenthal, M.N.: Chronic myelocytic leukemia: Origin of some lymphocytes from leukemic stem cells. J. Clin. Invest. (1978a). in press
Fialkow, P.J., Denman, A.M., Singer, J., Jacobson, R.J., Lowenthal, M.N.: Human myeloproliferative disorders: Clonal origin in pluripotent stem cells. Proc. 5th Cold Spring Harbor Conf. on Cell Prolif. (1978b) in press
Fischer, R., Schäfer, H.E.: Zur pathologischen Anatomie der Panmyelopathies und des Hypersplenismus. Internist 12, 151–161 (1971)
Gallo, R.C.: Terminal transferase and leukemia. N. Engl. J. Med. 292, 804–805 (1975)
Georgii, A., Vykoupil, K. F.: Pathologische Anatomie der megakaryocytären Myelose. In: Leukämie. Gross, R., Van de Loo, J. (eds.). pp. 25–28. Berlin, Heidelber, New York: Springer 1972
Georgii, A., Thiele, J.: Chronische myeloische Leukämie. In: Elektronenmikroskopische Hämatologie. Ruzicka, F. (ed.). pp. 129–163. Berlin, Heidelberg, New York: Springer 1976
Georgii, A., Vykoupil, K. F.: Histologisch-bioptische Klassifizierung myeloproliferativer Erkrankungen. In: Erkrankungen der Myelopoese. Leukämie. myeloproliferatives Syndrom, Polyzythämie. Stacher, A., Hocker, P. (eds.). pp. 47–58. Wien: Urban und Schwarzenberg 1976
Golomb, H.M., Vardiman, J., Rowley, J.D.: Acute nonlymphocytic leukemia in adults: Correlations with Q-banded chromosomes. Blood 48, 9–21 (1976)
Gordon, D. S., Hubbard, M.: Surface membrane characteristics and cytochemistry of the abnormal cells in adult acute leukemia. Blood 51, 681–692 (1978)
Gralnick, H.R., Harbor, J., Vogel, Ch.: Myelofibrosis in chronic granulocytic leukemia. Blood 37,152–162 (1971)
Greaves, M.F.: Clinical applications of cell surface markers. Prog, in Hematol. 9, 255–303 (1975)
Greenberg, P., Mara, B., Bax, I., Brossel, R., Schrier, S.: Evolution of myeloproliferative disorders. Abstr. 16th Intern. Congr. Hematol., Kyoto/Japan 1976
Greenberg, P.: Implications of in vitro marrow clonal growth studies for human disorders of granulopoietic regulation. In: Hemopoietic Cell Differentiation (ICN-UCLA Symposia on Molecular and Cellular Biology. Vol. X). Golde, D.W., Cline, M.J., Metcalf, D., Fox, C.F. (eds.). New York: Academic Press 1978
Hoffbrand, A.V., Ganeshaguru, K., Janossy, G., Greaves, M.F., Catanovsky, D., Woodruff, R. K.: Terminal deoxynucleotidyl-transferase levels and membrane phenotypes in diagnosis of acute leukemia. Lancet 1977 II, 520–523
Jamshidi, K., Swaim, W. R.: Bone marrow biopsy with unaltered architectur — a new biopsy device. J. Lab. Clin. Med. 77, 335–342 (1971)
Janossv, G., Greaves, M.F., Sutherland, R.: Comparative analysis of membrane phenotypes in acute lymphoid leukemia and in lymphoid blast crisis of chronic myeloid leukaemia. Leukaemia Res. 1, 289–300 (1977)
Krmpotic, E., Lewis, J. P., Donnelly, W.J.: Chromosome aberrations in two patients with chronic granulocytic leukemia undergoing acute transformation. Am. J. Clin. Pathol. 49, 161–170 (1968)
Leder, L. D.: Histochemie und Cytochemie der Leukosen. In: Leukamie. Gross, R., Van de Loo, J. (eds.). pp. 99–118. Berlin, Heidelberg, New York: Springer 1972
Lennert, K., Nagai, K., Schwarze, E.-W.: Patho-anatomical features of the bone marrow in polycythaemia and myelofibrosis. Clin. Haematol. 4, 331–351 (1975)
Loftier, H.: Die akuten unreifzelligen Leukämien. In: Knochenmark: Morphologic, Funktion, Diagnostik. Queisser, W. (ed.). pp. 273–294. Stuttgart: Thieme 1978
McCaffrey, R., Harrison, A., Parkman, R., Baltimore, D.: Terminaldeoxynucleotidvl transferase activity in human leukemic cells and in normal human thymocytes. N. Engl. J. Med., 292, 775–780 ( 1975)
Mertelsmann, R., Koziner, B., Filippa, D., Grossbard, E., Moore, M.A.S., Clarkson, B.D.: Classification of human hematopoietic neoplasias based on terminal deoxynucleotidyl transferase activities, cell surface marker analysis, marrow culture criteria, conventional morphology and clinical features. In: Modern Trends in Leukemia III. Neth, R., P.-H. Hofschneider, K. Mannweiler (eds.). Berlin, Heidelberg, New York: Springer 1978
Metcalf, D.: Regulation of granulocyte and monocyte-macrophage proliferation by colony stimulatory factor (CSF): A review. Exp. Hematol. 1, 185–201 (1973)
Metcalf, D.: Regulation by colony-stimulating factor of granulocytic and macrophage colony formation in vitro by normal and leukemic cells. In: Control of proliferation in animal cells. Baserga, R. (ed.). Cold Spring Harbor, N.Y.: Cold Spring Harbor Laboratory 1974
Metcalf, D.: Hemopoietic colonies. In vitro cloning of normal and leukemic cells. Recent Results Cancer Res. 61, 1–227 (1977)
Moore, M.A.S.: Regulatory role of macrophages in hemopoiesis. J. Reticuloendothel. Soc. 20, 89–91 (1976)
Rappaport, H.: Acute megakaryocytic myelosis. In: Tumors of the hematopoetic system. Atlas of Tumor Path., Sect. III-Fascicle 8. pp. 294–300. Armed Forces Institute of Pathology. Washington. D.C. 1966
Rosenthal, S., Canellos, G.P., De Vita, V.T., Gralnick, H.R.: Characteristics of blast crisis in chronic granulocytic leukemia. Blood 49, 705–713 (1977)
Rowley, J. D.: The role of cytogenetics in hematology. Editorial review. Blood 48, 1–7 (1976)
Rowley, J.D.: Cytogenetics in human leukemia. In: Modern Trends in Leukemia III. Neth, R., P.-H. Hofschneider, K. Mannweiler (eds.). Berlin, Heidelberg, New York: Springer 1978
Sandberg, A. A., Hossfeld, D. K.: Chromosomal abnormalities in human neoplasia. Ann Rev. Med. 21, 379–408 (1970)
Schmalzl, F., Abbrederis, K., Braunsteiner, H.: Zytochemische Klassifizierung der akuten Hämoblastosen. Lab. med. 1, 99–105 (1977)
Thiele, J., Ballard, A. Ch., Georgii, A.: Freeze-fracture of the normal and pathological megakaryocytic lineage in chronic megakaryocytic-granulocytic myelosis. Virchows Arch. B Cell Path. 23, 33–51 (1977a)
Thiele, J., Ballard, A.Ch., Georgii, A., Vykoupil, K. F.: Chronic megakaryocytic-granulocytic myelosis — An electron microscopic study. I. Megakaryocytes and thrombocytes. Virchows Arch. A Path. Anat. and Histol. 373, 191–211 (1977b)
Thiele, J., Ballard, A.Ch., Georgii, A., Vykoupil, K.F.: Chronic megakaryocytic-granulocytic myelosis — An electron microscopic study including freeze-fracture. II. Granulocytes. erythrocytes, plasma cells and myeloid stroma. Virchows Arch. A Path. Anat. and Histol. 375, 129–146 (1977c)
Vykoupil, K. F., Thiele, J., Georgii, A.: Histochemical and immunohistochemical techniques on acrylate embedded bone biopsies. Blut 32, 215–218 (1976)
Ward, H.P., Block, M.H.: The natural history of agnogenic myeloid metaplasia (AMM) and a critical evaluation of its relationship with the myeloproliferative syndrome. Medicine 50, 357–420 (1971)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1979 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Georgii, A. (1979). Histopathology of Bone Marrow in Human Chronic Leukemias. In: Neth, R., Gallo, R.C., Hofschneider, PH., Mannweiler, K. (eds) Modern Trends in Human Leukemia III. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 23. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67057-2_7
Download citation
DOI: https://doi.org/10.1007/978-3-642-67057-2_7
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-08999-5
Online ISBN: 978-3-642-67057-2
eBook Packages: Springer Book Archive