Abstract
The clinical syndromes which are associated with snakebite are variable. While minor reactions consist only of local pain and swelling, severe reactions may include muscular weakness or paralysis, respiratory failure, hemorrhage, hypotension, shock, and death. Hematologic changes predominate in crotalid and viperid envenomation. Elapid venom produces neuromuscular symptoms with or without local tissue necrosis. There is usually little cardiodepressor effect. Sea snake venom, on the other hand, is not only neurotoxic but also myotoxic, causing myonecrosis which is responsible for muscular pains and paresis.
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References
Amorim, M.F., Mello, R.F.: Intermediate nephron nephrosis from snake poisoning in man. Amer. J. Path. 30, 479–499 (1954)
Azevedo, A. de, Castro Teixeira, J. de: Intoxicacao pro veneno de cobra. Necrose symetrica da cortex renal uremia. Mem. Inst. Cruz. 33, 23–38 (1938)
Bokisch, V., Müller-Eberhard, H. J., Cochrane, C.G.: Isolation of a fragment (C3a) of the third component of human complement containing anaphylatoxin and chemotactic activity and description of an anaphylatoxin inactivator of human serum. J. exp. Med. 129, 1109–1130 (1969)
Brain, M.C., Esterly, J.R., Beck, E. A.: Intravascular hemolysis with experimentally produced vascular thrombi. Br. J. Haematol. 13, 868–891 (1957)
Brazil, O. V., Farina, R., Yoshida, L., Oliveira, V. A. de: Pharmacology of crystalline crotoxin. III. Cardiovascular and respiratory effects of crotoxin and Crotalus durissus terrificus venom. Mem. Inst. Butantan 33, 993–1000 (1966)
Bruninga, G.L.: Complement: A review of the chemistry and reaction mechanism. Amer. J. clin. Path. 55, 273–282 (1971)
Chugh, K. S., Aikat, B. K., Sharma, B. K., Dash, K. C., Mathew, M. T., Das, K. C.: Acute renal failure following snakebite. Amer. J. trop. Med. Hyg. 24, 692–697 (1975)
Clarkson, A.R., MacDonald, M.K., Fuster, V., Cash, J. D., Robson, J.S.: Glomerular coagulation in acute ischaemic renal failure. Quart. J. Med. 39, 585–599 (1970)
Danzig, L.E., Abels, G.H.: Hemodialysis of acute renal failure following rattlesnake bite, with recovery. J. Amer. med. Ass. 175, 136–137 (1961)
Deykin, D.: The clinical challenge of disseminated intravascular coagulation. New Engl. J. Med. 283, 636–644(1970)
Dodds, W.J., Pickering, R.J.: The effect of cobra venom factor on hemostasis in guinea pigs. Blood 40, 400–411(1972)
Donaldson, V.H.: Mechanism of activation of C1 esterase in hereditary angioneurotic edema plasma in vitro. The role of Hagemen factor, a clot-promoting agent. J. exp. Med. 227, 411 – 429 (1968)
Efrati, P., Reif, L.: Clinical and pathological observation on sixty-five cases of viper bite in Israel. Amer. J. trop. Med. Hyg. 2, 1085–1108 (1953)
Fidler, H.K., Glasgow, R. D., Carmicheal, E.B.: Pathological changes produced by subcutaneous injection of rattlesnake (Crotalus) venom into Macaca mullata monkeys. Amer. J. Path. 16, 355–364(1940)
Frazier, D.B., Carter, F.H.: Use of the artificial kidney in snakebite. Calif. Med. 97, 177–178 (1962)
Furtado, M. A., Lester, I. A.: Myoglobinuria following snakebite. Med. J. Aust. 1, 674–676 (1968)
Hadler, W.A., Brazil, O.V.: Pharmacology of crystalline crotoxin. IV. Nephrotoxicity. Mem. Inst. Butantan 33, 1001–1008 (1966)
Halmagyi, D.F., Starzecki, B., Horner, G. J.: Mechanism and pharmacology of shock due to rattlesnake venom in sheep. J. appl. Physiol. 20, 709–718 (1965)
Jiménez-Porras, J. M.: Biochemistry of snake venoms (a review). Clin. Toxicol. 3, 389–431 (1970)
Luna, G.: Manual of Histologic Staining Methods of the Armed Forces Institute of Pathology, 3rd Ed. New York: McGraw-Hill 1960
Marsden, A.T.H., Reid, H.A.: Pathology of sea-snake poisoning. Brit. med. J. 1961I, 1290–1293
McKay, D.G., Margaretten, W.: Disseminated intravascular coagulation in virus diseases. Arch. intern. Med. 120, 129–152 (1967)
Miescher, P.A., Müller-Eberhard, H.J.: Textbook of Immunopathology, Vol. I, 1st Ed. New York-London: Grune & Stratton 1968
Naish, P.F., Aber, G.M., Boyd, W.N.: C3 deposition in renal arterioles in the loin pain and haematuria syndrome. Brit. med. J. 1975III, 746
Ohsaka, A., Just, M., Habermann, E.: Action of snake venom hemorrhagic principles on isolated glomerular basement membrane. Biochim. biophys. Acta (Amst.) 323, 415–428 (1973)
Oram, S., Ross, S., Pell, L., Winteler, J.: Renal cortical calcification after snakebite. Brit. med. J. 1963I, 1647–1648
Pearce, R.M.: An experimental glomerular lesion caused by venom (Crotalus adamanteus). J. exp. Med. 11, 532–540 (1909)
Peiris, O.A., Wimalaratne, K. D. P., Nimalasuriya, A.: Exchange transfusion in the treatment of Russell’s viper bite. Postgrad, med. J. 45, 627–629 (1969)
Raab, W., Kaiser, E.: Nephrotoxic action of snake venom. Mem. Inst. Butantan 33, 1017–1020 (1966)
Ruddy, S., Giglo, I., Austen, K. F.: The complement system in man. Part IV. New Engl. J. Med. 287, 642–646 (1972)
Sant, S.M., Purandare, N.M.: Autopsy study of cases of snake bite with special reference to renal lesions. J. postgrad. Med. 18, 181–188 (1972)
Seedat, Y.K., Reddy, J., Edington, D. A.: Acute renal failure due to proliferative nephritis from snake bite poisoning. Nephron 13, 455–463 (1974)
Silva, H.B., Brito, T., Lima, P. R., Penna, D.O., Almeida, S. S., Mattar, E.: Acute anuric renal insufficiency due to snake, waxbee and spider bites. Clinical and pathological observations in 8 cases. Abstract II. Free communications. 3rd International Congress of Nephrology, 1966
Sitprija, V., Benyajati, C., Boonpucknavig, V.: Further observations of renal insufficiency in snakebite. Nephron 13, 396–403 (1974)
Sitprija, V., Benyajati, C., Boonpucknavig, V.: Renal involvement in snakebite. In: Ohsaka, A., Hayashi, K., Sawai, Y. (Eds.): Animal, Plant, and Microbial Toxins. Vol. 2, p.p. 483–495, New York: Plenum 1976
Sitprija, V., Sribhibhadh, R., Benyajati, C.: Haemodialysis in poisoning by sea-snake venom. Brit. med. J. 1971III, 218–219
Sitprija, V., Sribhibhadh, R., Benyajati, C., Tangchai, P.: Acute renal failure in snakebite. In: de Vries, A., Kochva, E. (Eds.): Toxins of Animal and Plant Origins, Vol. 3. London: Gordon and Breach 1973
Steinbeck, A. W.: Nephrotic syndrome developing after snakebite. Med. J. Aust. 1, 543–545 (1960)
Varagunam, T., Panabokke, R.G.: Bilateral cortical necrosis of the kidneys following snakebite. Postgrad, med. J. 46, 449–451 (1970)
Vassalli, P., McCluskey, R.T.: The coagulation process arid glomerular disease. Amer. J. Med. 39, 179–182 (1965)
Visuvaratnam, M., Vinayagamoorthy, C., Balakrishnam, S.: Venomous snakebite in North Ceylon: a study of 15 cases. J. trop. Med. Hyg. 73, 9–14 (1970)
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Sitprija, V., Boonpucknavig, V. (1979). Snake Venoms and Nephrotoxicity. In: Lee, CY. (eds) Snake Venoms. Handbook of Experimental Pharmacology, vol 52. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66913-2_28
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DOI: https://doi.org/10.1007/978-3-642-66913-2_28
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