Abstract
The dependence of carotid body oxygen consumption upon the oxygen partial pressure (PO2) (3,10) provides a basic mechanism for PO2 detection, and the low-affinity cytochrome a 3 found by Mills and Jobsis (11) and probably located in type I cells accounts for the dependence of the carotid body oxygen consumption upon PO2 in an unusually wide range. The excitatory effect of mitochondrial electron transport inhibitors (CO, HCN, etc.) on chemoreceptors implies that mitochondrial oxygen consumption is involved in PO2 sensing. However, the excitation of chemoreceptors by uncouplers of oxidative phosphorylation means that the cessation of a process energetically coupled to the electron transport (ATP synthesis, calcium uptake by mitochondria) could represent a necessary step in this excitation mechanism.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Alnaes, E., Rahaminoff, H.: J. Physiol. 248, 285–306 (1975)
Anichkov, S.V., Belen’Kii, M.L.: Pharmacology of the Carotid Body Chemoreceptors. Oxford: Pergamon 1963
Daly, M. de Burgh, Lambertsen, C.J., Schweitzer, A.: J. Physiol. 125, 67–89 (1954)
Eyzaguirre, C., Zapata, P.: in: Arterial Chemoreceptors. Torrance, R.W. (ed.). Oxford: Blackwell 1968, pp. 213–247
Eyzaguirre, C., Leitner, L.M., Nishi, K., Fidone, S.: J. Neurophysiol. 33, 685–696 (1970)
Forrester, T., Harper, A.M., McKenzie, E.T.: J. Physiol. 250, 38–39 (1975)
Hodgson, B.J., Kidwat, A.M., Daniel, E.E.: Can. J. Physiol. Pharmacol. 50, 730–733 (1972)
Joels, N., Neil, E.: in: Arterial Chemoreceptors. Torrance, R.W. (ed.). Oxford: Blackwell 1968, pp. 153–176
Krylow, S.S., Anichkov, S.V.: in: Arterial Chemoreceptors. Torrance, R.W. (ed.). Oxford: Blackwell 1968, pp. 103–109
Leitner, L.M., Liaubet, N.J.: Pfluegers Arch. 323, 315–322 (1971)
Mills, F., Jöbsis, F.F.: J. Neurophysiol. 5, 405–428 (1972)
Singer, M., Krishnan, N., Fyfe, D.A.: Anat. Rec. 173, 375–390 (1972)
Vogel, W.: Pfluegers Arch. 350, 25–40 (1974)
Takata, M., Pickard, W.F., Lettvin, J.Y., Moore, J.W.: J. Gen. Physiol. 50, 461–471 (1966)
Editor information
Rights and permissions
Copyright information
© 1977 Springer-Verlag Berlin · Heidelberg
About this paper
Cite this paper
Roumy, M., Leitner, L.M. (1977). Role of Calcium Ions in the Mechanism of Arterial Chemoreceptor Excitation. In: Acker, H., Fidone, S., Pallot, D., Eyzaguirre, C., Lübbers, D.W., Torrance, R.W. (eds) Chemoreception in the Carotid Body. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66755-8_36
Download citation
DOI: https://doi.org/10.1007/978-3-642-66755-8_36
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-08455-6
Online ISBN: 978-3-642-66755-8
eBook Packages: Springer Book Archive