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Relation of Herpes Simplex Viruses to Human Malignancies

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Current Topics in Microbiology and Immunology

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 77))

Abstract

We have been asked to provide our evaluation of the available data concerning the role of herpes simplex viruses in human malignancies. Perhaps we can begin by stating a set of criteria which, if fulfilled, would satisfy us that a particular virus was the causative agent of a particular malignancy. These requirements will form the framework around which the topic will be developed. Of course, we do not wish to imply that these criteria are original or that the form in which we have stated them is unique. These criteria include the following points: (1) There should be some epidemiologic or biological association or link between the malignancy and the suspected virus; (2) Purified preparations of the virus should induce tumors in its natural host or a similar species, and the resulting tumors should be similar to naturally occurring ones; (3) Ideally, one might hope to find similar naturallyoccurring malignancies in other animals caused by similar viruses; (4) The virus should transform cells in culture, and transformed cells should induce tumors similar to naturally occurring ones, and conversely, tumor cells cultured in vitro should be similar to transformed cells; (5) It should be possible to prevent the malignancy by preventing infection with the suspected virus. Needless to say, the different criteria carry different weight, and fulfillment of the second or fifth criteria stated above would provide very strong evidence for an etiologic role of the virus.

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References

  • Abrahams, P. J., Mulder, C., Warnaar, S. O., van de Voorde, A., van der Eb, A. J.: Transformation of primary rat kidney cells by fragments of simian virus 40 DNA. j. Virol. 16, 818–823 (1975)

    CAS  Google Scholar 

  • Adam, E., Kaufman, R. H., Melnick, J. L., Levy, A.H., Rawls, W.E.: Seroepidemiologic studies of herpesvirus type 2 and carcinoma of the cervix. III. Houston, Texas. Amer. J. Epidem. 96, 427–442 (1972a)

    Google Scholar 

  • Adam, E., Sharma, S.D., Zeigler, O., Iwamoto, L., Melnick, J.L., Levy, A.H., Rawls, W.E.: Seroepidemiologic studies of herpesvirus type 2 and carcinoma of the cervix. II. Uganda. J. nat. Cancer Inst. 48, 65–72 (1972b)

    CAS  Google Scholar 

  • Adam, E., Rawls, W.E., Melnick, J.L.: The association of herpesvirus type 2 infection and cervical carcinoma. Pre v. Med. 3, 122–141 (1974)

    CAS  Google Scholar 

  • Adelusi, B., Osunkoya, B. O., Fabiyi, A.: Antibodies to herpesvirus type 2 in carcinoma of the cervix uteri in Ibadan, Nigeria. Amer. J. Obstet. Gynec. 123, 758–761 (1975)

    PubMed  CAS  Google Scholar 

  • Alexander, E. R.: Possible etiologies of cancer of the cervix other than herpesvirus. Cancer Res. 33, 1485–1496 (1973)

    PubMed  CAS  Google Scholar 

  • Anzai, T., Dreesman, G.R., Courtney, R.J., Adam, E., Rawls, W.E., Benyesh-Melnick, M.: Antibody to herpes simplex virus type 2 - induced nonstructural proteins in women with cervical cancer and in control groups. J. Nat. Cancer Inst. 45, 1051–1059 (1975)

    Google Scholar 

  • Aurelian, L., Strandberg, J.D., Daves, H.J.: HSV-2 antigens absent from biopsied cervical tumor cells: A model consistent with latency. Proc. Soc. exp. Biol. (N.Y) 140, 404–408 (1972)

    CAS  Google Scholar 

  • Aurelian, L., Davis, H.J., Julian, C.G.: Herpesvirus type 2–induced tumor-specific antigen in cervical carcinoma. Amer. J. Epidem. 98, 1–9 (1973)

    CAS  Google Scholar 

  • Aurelian, L., Smith, M.E., Cornish, D.J.: IgM antibody to tumorassociated antigen (AG-4) induced by herpes simplex virus type 2: Its use in location of the antigen in infected cells. J. nat. Cancer Inst. 56, 417–477 (1976)

    Google Scholar 

  • Aurelian, L., Strand, B. C.: Herpesvirus type 2–related antigens and their relevance to humoral and cell-mediated immunity in patients with cervical cancer. Cancer Res. 36, 810–829 (1976)

    PubMed  CAS  Google Scholar 

  • Bacchetti, S., Graham, F.: Transfer of gene for thymidine kinase to thymidine kinase-deficient human cells by purified herpes simplex viral DNA. Proc. Natl. Acad. Sci. USA 74, 1590–1595 (1977)

    PubMed  CAS  Google Scholar 

  • Benyesh-Melnick, M., Schaffer, P.A., Courtney, R.J., Esparza, J., Kinura, S.: Viral gene function expressed and detected by temperature-sensitive mutants of herpes simplex virus. Cold Spr. Harb. Symp. quant. Biol. 39, 731–746 (1974)

    Google Scholar 

  • Black, F.L., Hierholzer, W.J., De Pinheiro, F., Evans, A.S., Woodall, J.P., Option, E.M., Emmons, I.E., West, B.S., Edsall, G., Downs, W.G., Wallace, G.D.: Evidence for persistence of infectious agents in isolated human populations. Amer. J. Epidem. 100, 230–250 (1974)

    CAS  Google Scholar 

  • Blank, H., Haines, H. G.: Experimental human reinfection with herpes simplex virus. J. invest. Derm. 61, 223–225 (1973)

    PubMed  CAS  Google Scholar 

  • Boyd, A.L., Orme, T.W.: Transformation of mouse cells after infection with ultraviolet-irradiation-inactivated herpes simplex virus type 2. Int. J. Cancer 16, 526–538 (1975)

    PubMed  CAS  Google Scholar 

  • Catalano, L. W.Jr., Johnson, L.H.: Herpesvirus antibody and carcinoma in situ of the cervix. J. Amer. med. Ass. 277, 447–450 (1971)

    Google Scholar 

  • Chadha, K. C., Munyon, W.: Presence of herpes simplex virus-related antigens in transformed L cells. J.Virol. 75, 1475–1486 (1975)

    Google Scholar 

  • Christenson, B., Espmark, A.: Long-term follow-up studies on herpes simplex antibodies in the course of cervical cancer. II. Antibodies to surface antigen of herpes simplex virus infected cells. Int. J. Cancer 77, 318–325 (1976)

    Google Scholar 

  • Cellard, W., Thornton, H., Green, M.: Cells transformed by human herpesvirus type 2 transcribe virus-specific RNA sequences shared by herpesvirus type 1 and 2. Nature (New Biol.) 243, 264–266 (1973)

    Google Scholar 

  • Coppleson, M., Reid, B., Pixley, E.: Preclinical Carcinoma of the Cervix Uteri. London: Permagon Press 1967

    Google Scholar 

  • Darai, G., Munk, K.: Human embryonic lung cells abortively infected with herpesvirus hominis type 2 show some properties of cell transformation. Nature (New Biol.) 241, 268–269 (1973)

    CAS  Google Scholar 

  • Davis, D.B., Kingsbury, D. T.: Quantitation of the viral DNA present in cells transformed by UV-irradiated herpes simplex virus. J. Virol. 77, 793–799 (1976)

    Google Scholar 

  • Duff, R., Rapp, F.: Properties of hamster embryo fibroblasts transformed in vitro after exposure to ultraviolet-irradiated herpes simplex virus type 2. J. Virol. 8, 469–477 (1971a)

    PubMed  CAS  Google Scholar 

  • Duff, R., Rapp, F.: Oncogenic transformation of hamster cells after exposure to herpes simplex virus type 2. Nature (New Biol.) 233, 48–50 (1971b)

    CAS  Google Scholar 

  • Duff, R., Rapp, F.: Oncogenic transformation of hamster embryo cells after exposure to inactivated herpes simplex virus type 1. J. Virol. 72, 209–217 (1973)

    Google Scholar 

  • Duff, R., Rapp, F.: Quantitative assay for transformation of 3T3 cells by herpes simplex virus type 2. J.Virol. 75, 490–496 (1975)

    Google Scholar 

  • Duff, R., Krender, J.W., Levy, B.M., Katz, M., Rapp, F.: Comparative pathology of cells transformed by herpes simplex virus type 1 or type 2. J. nat. Cancer Inst. 53, 1159–1164 (1974)

    PubMed  CAS  Google Scholar 

  • Epstein, M.I.: Epstein-Barr virus — Is it time to develop a vaccine program ? J. nat. Cancer Inst. 56, 697–700 (1976)

    PubMed  CAS  Google Scholar 

  • Freedman, R. S., Joosting, A. C., Ryan, J. T., Nkoni, S.: A study of associated factors, including genital herpes, in black women with cervical carcinoma in Johannesburg. S. Afr. med. J. 48, 1747–1752 (1974)

    Google Scholar 

  • Frenkel, N., Roizman, B., Cassai, E., Nahmias, A.: A DNA fragment of herpes simplex 2 and its transcription in human cervical cancer tissue. Proc. nat. Acad. Sci. (Wash.) 69, 3784–3789 (1972)

    CAS  Google Scholar 

  • Frenkel, N., Locker, H., Cox, B., Roizman, B., Rapp, F.: Herpes simplex virus in DNA in transformed cells; sequence complexity in five hamster cell lines and one derived hamster tumor. J.Virol. 18, 885–893 (1976)

    PubMed  CAS  Google Scholar 

  • Graham, F. L., van der Eb, A. J.: A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52, 456–467 (1973)

    PubMed  CAS  Google Scholar 

  • Graham, F.L., Veldhuisen, G., Wilkie, N. M.: Infectious herpesvirus DNA. Nature (New Biol.) 245, 265–266 (1973)

    CAS  Google Scholar 

  • Graham, F.L., van der Eb, A. J., Heijneker, H.L.: Size and location of the transforming region in human adenovirus type 5 DNA. Nature (Lond.) 257, 687–691 (1974a)

    Google Scholar 

  • Graham, F.L., Abrahams, P. J., Mulder, C., Heijneker, H.L., Warnaar, S.O.,De Vries, F.A.J., Fiers, W., van de Eb, A. J.: Studies on in vitro transformation by DNA and DNA fragments of human adenoviruses and simian virus 40. Cold Spr. Harb. Symp. quant. Biol. 39, 637–650 (1974b)

    Google Scholar 

  • Hampar, B., Aaronson, S.A., Derge, J.G., Chakrabarty, M., Showalter, S.D., Dunn, C.Y.: Activation of an endogenous mouse type C virus by ultraviolet-irradiated herpes simplex virus types 1 and 2. Proc. Nat. Acad. Sci. (USA) 73, 646–650 (1976)

    CAS  Google Scholar 

  • Hay, J., Moss, H., Halliburton, I.W.: Induction of deoxyribonucleic acid polymerase and deoxyribonuclease activities in cells infected with herpes simplex virus type 2. Biochem. J. 124, 64 (1971)

    Google Scholar 

  • Hayward, G.S., Frenkel, N., Roizman, B.: Anatomy of herpes simplex virus DNA: Strain differences and heterogenity in the locations of restriction endonuclease cleavage sites. Proc. nat. Acad. Sci. (Wash.) 72, 1768–1772 (1975)

    CAS  Google Scholar 

  • Hayward, G. S., Jacob, R.J., Wadsworth, S. C., Roizman, B.: Anatomy of herpes simplex virus DNA: Evidence for four populations of molecules that differ in the relative orientations of their long and short components. Proc. nat. Acad. Sci. (Wash.) 72, 4243–4247 (1975b)

    CAS  Google Scholar 

  • Heyerdahl, T.O.: Type 1 and type 2 herpesvirus and abnormal cervical cytology. J. Irish med. Ass. 67, 445–447 (1974)

    CAS  Google Scholar 

  • Hollinshead, A., Lee, O.B., McKelway, W., Melnick, J.L., Rawls, W.E.: Reactivity between herpesvirus type 2-related soluble cervical tumor cell membrane antigens and matched cancer and control sera. Proc. Soc. exp. Biol. (N. Y) 141, 688–693 (1972)

    CAS  Google Scholar 

  • Hollinshead, A. C., Lee, O., Chretian, P.B., Tarpley, J.L., Rawls, W.E., Adam, E.: Antibodies to herpesvirus nonvirion antigens in squamous carcinoma. Sci. 182, 713–715 (1973)

    CAS  Google Scholar 

  • Hollinshead, A.C., Tarro, C.: Soluble membrane antigens of lip and cervical carcinomas: Reactivity with antibody for herpesvirus nonvirion antigens. Sci. 179, 698–700 (1973)

    CAS  Google Scholar 

  • Hollinshead, A.C., Tarro, G., Chretian, P., Rawls, W.E.: Characterization of herpesvirus nonvirion antigens: Relation to squamous cell carcinomas. In: Viral Immunodiagnosis. Kurstak, E., Morisset, R. (eds.). New York: Academic Press, Inc., 1974, pp. 301–319

    Google Scholar 

  • Hollinshead, A.C., Chretien, P.B., Lee, O.B., Tarpley, J.L., Kerney, S.E., Silverman, N.A., Alexander, J. C.: In vivo and in vitro measurements of the relationship of human squamous carcinomas to herpes simplex virus tumor-associated antigens. Cancer Res. 36, 821–828 (1976)

    PubMed  CAS  Google Scholar 

  • Huebner, R.J., Todaro, G.J.: Oncogenes of RNA tumor viruses as determinants of cancer. Proc. nat. Acad. Sci. (Wash.) 64, 1087–1094 (1969)

    CAS  Google Scholar 

  • Hughes, R.G., Munyon, W.H.: Temperature-sensitive mutants of herpes simplex virus type 1 defective in lysis but not in transformation. J. Virol. 16, 275–283 (1975)

    PubMed  Google Scholar 

  • Jamieson, A.T., Gentry, G.A., Subak-Sharpe, J.H.: Induction of both thymidine and deoxycytidase kinase activity. J. gen. Virol. 24, 465–480 (1974)

    PubMed  CAS  Google Scholar 

  • Janda, Z., Kanka, J., Vonka, V., Svoboda, B.: A study of herpes simplex type 2 antibody status in groups of patients with cervical neoplasia in Czechoslovakia. Int. J. Cancer 12, 626–630 (1973)

    PubMed  CAS  Google Scholar 

  • Josey, W.E., Nahmias, A. J., Naib, Z. M.: The epidemiology of type 2 (genital) herpes simplex virus infections. Obstet. gynec. Surv. 27, 295–302 (1972)

    Google Scholar 

  • Kao, C.L., Chen, Y.A., Tang, M.C., Wen, K.H., Hsia, S.: Association of herpes simplex type 2 virus with cervical cancer of the uterus. J. Formosan med. Asso. 73, 122–127 (1974)

    CAS  Google Scholar 

  • Kawana, T., Yoshino, K, Kasamatsu, T.: Estimation of specific antibody to type 2 herpes simplex virus among patients with carcinoma of the uterine cervix. Gann. 65, 438–445 (1974)

    Google Scholar 

  • Kessler, 1.1., Kulcar, Z., Rawls, W.E., Smerderl, S., Strand, M., Lilienfield, A.M.: Cervical cancer in Yugoslavia. I. Antibodies to genital herpesvirus in cases and controls. J. nat. Cancer Inst. 52, 369–376 (1974)

    Google Scholar 

  • Kessler, 1.1.: Human cervical cancer as a venereal disease. Cancer Res. 36, 783–791 (1976)

    Google Scholar 

  • Kimura, S., Flannery, V.L., Levy, B., Schaffer, P. A.: Oncogenic transformation of primary hamster cells by herpes simplex virus type 2 (HSV-2) and an HSV-2 temperature-sensitive mutant. Int. J. Cancer 15, 786–798 (1975)

    PubMed  CAS  Google Scholar 

  • Kimura, S., Esparsa, J., Benyesh-Melnick, M., Schaffer, P.A.: Enhanced replication of temperature-sensitive mutants of HSV-type 2 at the nonpermissive temperature in cells transformed by HSV-2 Intervirology 3, 162–169 (1974)

    CAS  Google Scholar 

  • Kit, S., Dubbs, D.R.: Acquisition of thymidine kinase activity by herpes simplex infected mouse fibroblast cells. Biochem. biophys. Res. Commun. 11, 55–59 (1963)

    CAS  Google Scholar 

  • Kit, S., Leung, W. C., Jorgensen, G.N., Trkula, D., Dubbs, D.R.: Thymidine kinase isozymes of normal and virus-infected cells. Cold Spr. Harb. Symp. quant. Biol. 39, 703–716 (1974)

    Google Scholar 

  • Kutinova, L., Vonka, V., Broucek, J.: Increased oncogenicity and synthesis of herpesvirus antigens in hamster cells exposed to herpes simplex type-2 virus. J. nat. Cancer Inst. 50, 759–766 (1973)

    PubMed  CAS  Google Scholar 

  • Li, J.L., Jerkofsky, M.A., Rapp, F.: Demonstration of oncogenic potential of mammalian cells transformed by DNA-containing viruses following photodynamic inactivation. Int. J. Cancer 15, 190–202 (1975)

    PubMed  CAS  Google Scholar 

  • Littlefield, J. W.: Selection of hybrids from matings of fibroblasts in vitro and their presumed recominants. Sci. 145, 709–710 (1964)

    CAS  Google Scholar 

  • Lowry, S.P., Breswick, E., Rawls, W.E.: Differences in thymidine kinase-inducing ability of herpesvirus type 1 and 2. Virology 46, 958–961 (1971)

    PubMed  CAS  Google Scholar 

  • Macnab, J. C. M.: Transformation of rat embryo cells by temperature-sensitive mutants of HSV. J. gen. Virol. 24, 143–153 (1974)

    PubMed  CAS  Google Scholar 

  • Macnab, J.C.M.: Transformed cell lines produced by temperature-sensitive mutants of herpes simplex types 1 and 2. In: Second Int. Symp. Oncogenesis and Herpesviruses II. De-The, G., Epstein, M.A., and zur Hausen, H. (eds.). Switzerland, IARC Scientific Publications, 227–235 (1975)

    Google Scholar 

  • Macnab, J. C. M., Timbury, M. C.: Complementation of ts mutants by a herpes simplex virus ts-transformed cell line. Nature (Lond.) 261, 233–235 (1976)

    CAS  Google Scholar 

  • McAuslan, B.R.: Virus-associated enzymes. Life Sci. 14, 2083–2097 (1974)

    Google Scholar 

  • McClung, H., Seth, P., Rawls, W.E.: Relative concentrations in human sera of antibodies to cross-reacting and specific antigens of herpes simplex virus types 1 and 2. Amer. J. Epidem. 104, 192–201 (1977)

    Google Scholar 

  • McDonald, A.D., Williams, M. C., Manfreda, J., West, R.: Neutralizing antibodies to herpesvirus types 1 and 2 in carcinoma of the cervix, carcinoma in situ and cervical dysplasia. Amer. J. Epidem. 100, 130–135 (1974)

    CAS  Google Scholar 

  • Melnick, J.L., Courtney, R.J., Powell, K.L., Schaffer, P. A., Benyesh-Melnick, M., Dreesman, G.R., Anzai, T., Adam, E.: Studies on herpes simplex virus and cancer. Cancer Res. 36, 845–856 (1976)

    PubMed  CAS  Google Scholar 

  • Menczer, J., Leventon-Kriss, S., Modan, M., Oelsner, G., Gerichter, C. B.: Antibodies to herpes simplex virus in Jewish women with cervical cancer and in healthy Jewish women of Israel. J. nat. Cancer Inst. 55, 3–6 (1975)

    PubMed  CAS  Google Scholar 

  • Munk, W., Darai, G.: Human embryonic lung cells transformed by HSV. Cancer Res. 33, 1535–1538 (1973)

    PubMed  CAS  Google Scholar 

  • Munoz, N.: Effect of herpesvirus type 2 and hormonal imbalance on the uterine cervix of the mouse. Cancer Res. 33, 1504–1508 (1973)

    PubMed  CAS  Google Scholar 

  • Munoz, N., De-The, G., Aristzabal, N., Yee, C., Rabson, A., Pearson, G.: Antibodies to herpesviruses in patients with cervical cancer and controls. In: Second Int. Symp. Oncogenesis and Herpesviruses II. Dt-The, G., Epstein, M.A., and zur Hausen, H. (eds.). Switzerland, IARD Scientific Publications, 45–51 (1975)

    Google Scholar 

  • Munyon, W., Kraiselburd, E., Davies, D., Mann, J.: Transfer of thymidine kinase to thymidine kinaseless L cells by infection with ultraviolet-irradiated herpes simplex virus. J. Virol. 1, 813–820 (1971)

    Google Scholar 

  • Nahmias, A. J., Josey, W.E., Naib, Z.M., Luce, C.F., Guest, B.: Antibodies to herpesvirus hominis types 1 and 2 in humans. II. Women with cervical cancer. Amer. J. Epidem. 91, 547 (1970a)

    CAS  Google Scholar 

  • Nahmias, A. J., Naib, Z. M., Josey, W. E., Murphy, F. A., Luce, C. F.: Sarcomas after inoculation of newborn hamsters with herpesvirus hominis type 2 strains. Proc. Soc. exp. Biol. (N. Y.) 134, 1065–1069 (1970b)

    CAS  Google Scholar 

  • Nahmias, A. J., Naib, Z.M., Josey, W.E., Franklin, E., Jenkins, R.: Prospective studies of the association of genital herpes simplex infection and cervical anaplasia. Cancer Res. 33, 1491–1497 (1973)

    PubMed  CAS  Google Scholar 

  • Nahmias, A. J., Roizman, B.: Infection with herpes simplex viruses 1 and 2. New Engl. J. Med. 289, 661–614; 719–725; 781–789 (1973)

    Google Scholar 

  • Nahmias, A.J., Naib, Z.M., Josey, W.E.: Epidemiological studies relating genital herpetic infections to cervical carcinoma. Cancer Res. 34, 1111–1147 (1974)

    PubMed  CAS  Google Scholar 

  • Nahmias, A.J., Del Buono, I., Ibrahim, I.: Antigenic relationship between herpes simplex viruses, human cervical cancer and HSV-associated hamster tumours. In: Second Int. Symp. Oncogenesis and Herpesviruses II. De-The, G., Epstein, M.A., and zur Hausen, H. (eds.). Switzerland, IARC Scientific Publications, 309–313 (1975)

    Google Scholar 

  • Naib, Z.M., Nahmias, A. J., Josey, W.E., Zaki, S.A.: Relation of cytohistopathology of genital herpesvirus infections to cervical anaplasia. Cancer Res. 33, 1452–1463 (1973)

    PubMed  CAS  Google Scholar 

  • Notter, M.F.D., Docherty, J.J.: Comparative diagnostic aspects of herpes simplex virus tumor-associated antigens. J. nat. Cancer Inst. 1976

    Google Scholar 

  • Oriel, J.D., Hayward, A.H.S.: Sexually-transmitted diseases in animals. Brit. J. vener. Dis. 50 (6), 417–420 (1974)

    Google Scholar 

  • Ory, H., Conger, B., Ricbart, R., Barron, R.: Relation to type 2 herpesvirus antibodies to cervical neoplasia. Barbados, West Indies, 1971. Obstet. and Gynec. 43, 901–904 (1974)

    CAS  Google Scholar 

  • Ory, H.W., Jenkins, R., Byrd, J.Y., Nahmias, A. J., Tyler, C.W., Allen, D.T., Conger, S.B.: The epidemiology and interrelationships of cervical dysplasia and type 2 herpesvirus in a low-income housing project. Amer. J. Obstet. Gynec. 123, 269–21A (1975)

    PubMed  CAS  Google Scholar 

  • Pagano, J. S.: Disease and mechanisms of persistent DNA virus infection: Latency and cellular transformation. J. infect. Dis. 132, 209–223 (1975)

    PubMed  CAS  Google Scholar 

  • Palencia, P.G., London, W.T., Nahmias, A. J., Naib, Z.M., Tunca, J., Fyccillo, D.A., Ellenberg, J.H., Sever, J.L.: A preliminary report on investigation of oncogenic potential of herpes simplex virus type 2 in Cebus monkey. Cancer Res. 36, 807–809 (1976)

    Google Scholar 

  • Pada, M.R., Kummerlander, L., Pejtsik, B., Pali, K.: Herpesvirus antibodies and antigens in patients with cervical anaplasia and in controls. J. nat. Cancer Inst. 55, 775–781 (1975)

    Google Scholar 

  • Peltonen, R.: Antibodies to herpesvirus hominis types 1 and 2 among women with neoplastic changes of uterine cervix. Acta obstet. gynec. scand. 54, 369–372 (1975)

    PubMed  CAS  Google Scholar 

  • Plummer, G.: A review of the identification and titration of antibodies to herpes simplex viruses types 1 and type 2 in human sera. Cancer Res. 33, 1469–1476 (1973)

    PubMed  CAS  Google Scholar 

  • Plummer, G., Master son, J.G.: Herpes simplex virus and carcinomp of the cervix. Amer. J. Obstet Gynec. 3, 81–84 (1971)

    Google Scholar 

  • Rapp, F., Falk, L.A.: Study of virulence and tumorigenicity of varipnts of herpes simplex virus. Proc. Soc. exp. Biol. (N.Y.) 116, 361–365 (1964)

    CAS  Google Scholar 

  • Rapp, F., Duff, R.: Transformation of hamster embryo fibroblasts by herpes simplex virus type 1 and type 2. Cancer Res. 33, 1527–1534 (1973)

    PubMed  CAS  Google Scholar 

  • Rapp, F., Li, J. L. H., Jerkofsky, M.: Transformation of mammalian cells by DNA-containing viruses following photodynamic inactivation. Virology 55, 339–346 (1973)

    PubMed  CAS  Google Scholar 

  • Rapp, F.: Herpesviruses and cancer. Advanc. Cancer Res. 19, 265–302 (1974)

    CAS  Google Scholar 

  • Rapp, F., Li, J. L. H.: Demonstration of the oncogenic potential of herpes simplex viruses and human cytomegalovirus. Cold Spr. Harb. Symp. quant. Biol. 39, 747–763 (1975)

    Google Scholar 

  • Rawls, W.E., Tompkins, W.A.F., Melnick, J.L.: The association of herpesvirus type 2 and carcinoma of the uterine cervix. Amer. J. Epidem. 89, 547 (1969)

    CAS  Google Scholar 

  • Rawls, W. E., Adam, E., Melnick, J. L.: Geographic variations in the association of antibodies to herpesvirus type 2 and carcinoma of the cervix. In: Oncogenesis and Herpesviruses. De-The, G., Biggs, P. M., and Payne, L. N. (eds.). Lyon, France, IARC Scientific Publications, 424–427 (1972)

    Google Scholar 

  • Rawls, W.E., Gardner, H.L.: Herpes genitalis: Venereal aspects. Clin. Obstet. Gynec. 15, 912–918 (1972)

    Google Scholar 

  • Rawls, W.E., Adam, E., Melnick, J.L.: An analysis of seroepidemiological studies of herpesvirus type 2 and carcinoma of the cervix. Cancer Res. 33, 1477–1490 (1973)

    PubMed  CAS  Google Scholar 

  • Rawls, W.E., Garfield, C.H., Seth, P., Adam, E.: Serological and epidemiological considerations of the role of herpes simplex virus type 2 in cervical cancer. Cancer Res. 36, 829–835 (1976)

    PubMed  CAS  Google Scholar 

  • Rotkin, I. D.: A comparison review of key epidemiological studies in cervical cancer related to current seaches for transmissible agents. Cancer Res. 33, 1353–1367 (1973)

    PubMed  CAS  Google Scholar 

  • Royston, I., Aurelian, L.: The association of genital herpesvirus with cervical atypia and carcinoma in situ. Amer. J. Epidem. 91, 531–538 (1970a)

    CAS  Google Scholar 

  • Royston, I., Aurelian, L.: Immunofluorescent detection of herpesvirus antigens in exfoliated cells from human cervical carcinoma. Proc. nat. Acad. Sci. (Wash.) 67, 204 (1970b)

    CAS  Google Scholar 

  • Sabin, A.B., Tarro, G.: Herpes simplex and herpes genitalis viruses in etiology of some human cancers. Proc. nat. Acad. Sci. (Wash.) 70, 3225–3229 (1973)

    CAS  Google Scholar 

  • Sabin, A.B.: Herpes simplex-genitalis virus nonvirion antigens and their implication in certain human cancers: unconfirmed. Proc. nat. Acad. Sci. (Wash.) 71, 3248–3252 (1974)

    CAS  Google Scholar 

  • Schneweis, K.E., Haag, A., Lehmkoster, A., Kaenig, V.: Seroimmunological investigations in patients with cervical cancer: Higher rates of HSV-2 antibodies than in syphilis patients and evidence of IgM antibodies to an early HSV-2 antigen. In: Incogenesis and Herpesvirus II. De-The, G., Epstein, M.A., and zur Hausen, H. (eds.). Switzerland, IARC Scientific Publications, 53–57 (1975)

    Google Scholar 

  • Schulte-Holthausen, H.: Persistence of herpesvirus DNA. In: Third Int. Congress for Virology. Madrid, 1975, p. 120.

    Google Scholar 

  • Seth, P., Rawls, W.E., Duff, R., Rapp, F., Adam, E., Melnick, J.L.: Antigenic differences between isolates of herpesvirus type 2. Intervirology 3, 1–14 (1974)

    PubMed  CAS  Google Scholar 

  • Sever, J.L.: Herpesvirus and cervical cancer studies in experimental animals. Cancer Res. 33, 1509–1510 (1973)

    PubMed  CAS  Google Scholar 

  • Silverman, N.A., Alexander, J. C.Jr., Hollinshead, A.C., Chretian, P. B.: Correlation of tumor burden with in vitro lymphocyte reactivity and antibodies to herpesvirus tumor-associated antigens in head and neck squamous carcinoma. Cancer (Philad.) 37, 135–140 (1976)

    CAS  Google Scholar 

  • Share, J., Summers, W.P., Summers, W.C.: Structure and function of herpesvirus genomes. I. Comparison of five HSV-1 and two HSV-2 strains by cleavage of their DNA with Eco R I restriction endonuclease. J. Virol. 15, 726–732 (1975)

    Google Scholar 

  • Skinner, G.R.B., Thouless, M.E., Jordan, J. A.: Antibodies to type 1 and type 2 herpesvirus in women with abnormal cervical cytology. J. Obstet. Gynec. Brit. Commonw. 78, 1031–1038 (1971)

    CAS  Google Scholar 

  • Skinner, G.R.B., Taylor, J., Edwards, J.: Precipitating antibodies to herpes simplex virus in human sera: Prevalence of antibody to common antigen (Band II). Intervirology 4, 320–324 (1974)

    PubMed  CAS  Google Scholar 

  • Smith, J. W., Adam, E., Melnick, J. L., Rawls, W. E.: Use of the 51Cr release test to demonstrate patterns of antibody response in humans to herpesvirus types 1 and 2. J. Immunol. 109, 554–564 (1972)

    PubMed  CAS  Google Scholar 

  • Sprecher-Goldberger, S., Thiry, L., Cattoor, J.P., Hooghe, R., Pestcan, J.: Herpesvirus type 2 infection and carcinoma of the cervix. Lancet 2, 266 (1970)

    PubMed  CAS  Google Scholar 

  • Sprecher-Goldberger, S., Thiry, L., Gould, L, Fassin, Y., Gompel, C.: Increasing antibody titers to herpes simplex virus type 2 during follow-up women with cervical dysplasia. Amer. J. Epidem. 97, 103–110 (1973)

    CAS  Google Scholar 

  • Steinhart, W.L., Grafstrom, R.H., Hill, C.W.: Terminal fragments of herpes simplex virus DNA produced by restriction endonuclease. Biochem. biophys. Res. Commun. 67, 556–561 (1975)

    CAS  Google Scholar 

  • Takahashi, M., Yamanishi, K.: Transformation of hamster embryo and human embryo cells by temperature-sensitive mutants of herpes simplex virus type 2. Virology 61, 306–311 (1974)

    PubMed  CAS  Google Scholar 

  • Thiry, L., Sprecher-Goldberger, S., Fassin, Y., Gould, I., Compel, C., Pestiau, J.,DeHalleux, F.: Variations of cytotoxic antibodies to cells with herpes simplex antigens in women with proatessing or regressing cancerous lesions of the cervix. Amer. J. Epidem. 100, 251–561 (1974)

    CAS  Google Scholar 

  • Thouless, M. E.: Serological properties of thymidine kinase produced in cells infected with type 1 or type 2 herpes virus. J. gen. Virol. 17, 307–315 (1972)

    PubMed  CAS  Google Scholar 

  • Trentin, J. J., Van Hoosier, G.L., Boren, Ferguson, D.G., Kitamura, I.: Oncogenic evaluation in hamsters of human picorna-, paramyxo-, and herpesviruses. Soc. exp. Biol. (N.Y.) 132, 912–915 (1969)

    CAS  Google Scholar 

  • Vestgaard, B.F., Hornsleth, A., Pedersen, S.N.: Occurrence of herpes and adenovirus antibodies in patients with carcinoma of the cervix uteri. Cancer (Philad.) 30, 68–74 (1972)

    Google Scholar 

  • Weissbach, A., Hong, S.C.L., Aucker, J.. Muller, R.: Characterization of herpes simplex virus-induced deoxyribonucleic acid polymerase. J. biol. Chem. 248, 6270–6277 (1973)

    CAS  Google Scholar 

  • Wentz, W. B., Reagan, J. W., Heggie, A.D.: Cervical carcinogenesis with herpes simplex virus type 2. Obstet. and Gynec. 46, 117–121 (1975)

    CAS  Google Scholar 

  • Wilkie, N.M., Clements, J.B., Macnab, J.C.M., Subak-Sharpe, J.H.: The structure and biological properties of herpes simplex virus DNA. Cold Spr. Harb. Symp. quant. Biol. 39, 657–666 (1974)

    Google Scholar 

  • Zur Hausen, H., Schulte-Holthausen, H., Wolf, H., Dorries, K., Egger, H.: Attempts to detect virus-specific DNA in human tumors. II. Nucleic acid hybridizption with complementary RNA of human herpes group viruses. Int. J. Cancer. 13, 657–664 (1974)

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, McMaster University, Hamilton, Ontario, Canada

    William E. Rawls, Silvia Bacchetti & Frank L. Graham

  2. Department of Biology, McMaster University, Hamilton, Ontario, Canada

    William E. Rawls, Silvia Bacchetti & Frank L. Graham

  3. Research Scholars of the National Cancer Institute of Canada, Canada

    Silvia Bacchetti & Frank L. Graham

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  1. William E. Rawls
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  2. Silvia Bacchetti
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  3. Frank L. Graham
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Editors and Affiliations

  1. Basle, Switzerland

    W. Arber  & F. Melchers  & 

  2. Philadelphia, USA

    W. Henle , P. Koldovský  & H. Koprowski ,  & 

  3. Martinsried, Germany

    P. H. Hofschneider

  4. London, UK

    J. H. Humprey

  5. Dallas, USA

    J. Klein

  6. Copenhagen, Denmark

    O. Maaløe

  7. Gießen, Germany

    R. Rott

  8. Wilhelmshaven, Germany

    H. G. Schweiger

  9. Prague, Czech Republic

    L. Syruček

  10. Los Angeles, USA

    P. K. Vogt

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© 1977 Springer-Verlag Berlin · Heidelberg

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Rawls, W.E., Bacchetti, S., Graham, F.L. (1977). Relation of Herpes Simplex Viruses to Human Malignancies. In: Arber, W., et al. Current Topics in Microbiology and Immunology. Current Topics in Microbiology and Immunology, vol 77. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66740-4_3

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  • DOI: https://doi.org/10.1007/978-3-642-66740-4_3

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