Abstract
The medicinal chemist has long known that modifying a drug’s chemical structure may cause modified biologic response. If we accept the view that biologic reactions are subject to normal chemical forces, then the usual physical chemical concepts—e.g., thermodynamic and kinetic theory—should apply. However, early attempts to correlate biologic activity quantitatively with chemical structure, using the Hammett equation or Hückel molecular orbital calculations, met with only limited success (GOODFORD, 1973; PURCELL et al., 1973). It is now clear that this failure was due to the greater complexity of bioreactions compared to “normal” chemical reactions in homogeneous solution.
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Gund, P. (1977). Three-Dimensional Pharmacophoric Pattern Searching. In: Hahn, F.E., Kersten, H., Kersten, W., Szybalski, W. (eds) Progress in Molecular and Subcellular Biology. Progress in Molecular and Subcellular Biology, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66626-1_4
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