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Assessment of the Abuse Potentiality of Morphinelike Drugs (Methods Used in Man)

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Drug Addiction I

Abstract

As therapeutic agents, morphine and morphinelike drugs are indispensable, but these same agents are liable to nontherapeutic self-ingestion by segments of the population. Society has condemned this self-ingestion and its associated behaviors and has invoked stringent legal mechanisms controlling the manufacture and distribution of morphinelike drugs. In an attempt to develop analgesics, antitussives, and antidiarrheals that were devoid of those properties of morphine leading to abuse, a large number of drugs have been synthesized and studied. Few drugs have been discovered which exhibit this selectivity, but many have been found that are pharmacologically equivalent to morphine with a potential similar to morphine for abuse.

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  1. D. R. Jasinski
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  1. Department of Health, Education, and Welfare, Public Health Service, National Institute on Drug Abuse, Addiction Research Center, Lexington, KY, 40511, USA

    William R. Martin M.D.

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Jasinski, D.R. (1977). Assessment of the Abuse Potentiality of Morphinelike Drugs (Methods Used in Man). In: Martin, W.R. (eds) Drug Addiction I. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 45 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66612-4_4

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