Abstract
The chromosomes transmit the genetic information from one generation to the next; any alteration in their number or organization is bound to be of consequence. This is especially so in the performance of the reproductive system: chromosome aberrations are connected with sterility or reduced fertility, embryonic and fetal mortality, congenital malformations, and perinatal death.
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References
Austin, C.R.: Chromosome deterioration in aging eggs of the rabbit. Nature (Lond.) 213, 1018–1019 (1967).
Austin, C.R., Bishop, M. W.H.: Fertilization in mammals. Biol. Rev. 32, 296–349 (1957).
Austin, C.R., Braden, A. W.H.: Induction and inhibition of the second polar body division in the rat egg and subsequent fertilization. Aust. J. biol. Sci. 7, 195–199 (1954).
Barros, C., Vliegenhart, A.M., Franklin, L.E.: Polyspermic fertilization of hamster eggs in vitro. J. Reprod. Fertil. 28, 117–120 (1972).
Beatty, R.A.: Parthenogenesis and polyploidy in mammalian development. London: Cambridge University Press 1957.
Beatty, R.A.: In: Parthenogenesis in Vertebrates in Fertilization (eds. Metz, Monroy), Vol. 1, p. 413. New York: Academic Press 1967.
Beatty, R.A., Fechheimer, N.S.: Diploid spermatozoa in rabbit semen and their experimental separation from haploid spermatozoa. Biol. Reprod. 7, 267–277 (1972).
Böök, J.A., Santesson, B.: Nuclear sex in triploid XXY human cells. Lancet 1961 I, 318.
Bomsel-Helmreich, O.: Triploidie expériment ale chez quelques mammifères. Thèse Doctorat d’Etat, Paris, p. 112 (1967).
Bomsel-Helmreich, O.: Fate of heteroploid embryos. Advances in Biosciences. 6. Schering Symp. on Intrinsic and Extrinsic Factors in Early Mammalian Development (ed. Raspe) pp. 381–403. Oxford-Braunschweig: Pergamon Press, Vieweg 1970.
Bomsel-Helmreich, O.: Effects de l’ovulation retardée sur le développement des blastocystes de Lapine. VII. Int. Kongr. für tierische Fortpflanzung, München, Band II, 205–210 (1972).
Bomsel-Helmreich, O., Szöllösi, D.: The effect of environment on fertilization following delayed mating in the rabbit. Abstr. Soc. Study Fertil.(1974).
Bomsel-Helmreich, O., Thibault, C.: Fécondation in vitro en présence de colchicine et polyploidie expérimentale chez le Lapin. Ann. Biol. anim. Bioch. Biophys. 2, 13–16 (1962).
Boué, J.G., Philippe, E.: Les caractères anatomo-pathologiques des placentas humains selon les anomalies chromosomiques. C.R.Acad. Sci. (Paris) 269 (D) 535–537 (1969).
Braden A. W.H., Austin, C.R.: Reactions of unfertilized mouse eggs to some experimental stimuli. Exp. Cell Res. 7, 277–280 (1954).
Brown, S. W., Chandra, H.S.: Inactivation system of the mammalian X chromosome. Proc. nat. Acad. Sci. (Wash.) 70, 195–199 (1973).
Butcher, R.L., Fugo, N. W.: Overripe ness and the mammalian ova. II. Delayed ovulation and chromosome anomalies. Fertil. and Steril. 18, 297–306 (1967).
Chalmel, M. C.: Possibilité de fécondation des oeufs de lapine activés parthénogénétiquement. Ann. Biol. anim. Bioch. Biophys. 2, 279–297 (1962).
Chang, M.C., Fernandez-Cano, L.: Effects of delayed fertilization on the development of pronucleus and the segmentation of hamster ova. Anat. Rec. 132, 307–320 (1958).
Cure, S., Boué, A., Boue, J.: Consequence of chromosomal anomalies on cell multiplication. In: Les accidents chromosomiques de la Reproduction, pp. 95–109. Paris: Coll. INSERM 1973.
Dandekar, P. V., Fraser, L.R.: In vitro fertilization of rabbit eggs using vaginal sperm. Abstr. Soc. Study Fertil. (1974).
Day, B.N., Polge, C.: Effects of Progesterone on fertilization and egg transport in the pig. J. Reprod. Fertil. 17, 227–230 (1968).
Edwards, R.G.: Colchicine-induced heteroploidy in the mouse. I. The induction of triploidy by treatment of the gametes. J. exp. Zool. 137, 317–322 (1958).
Edwards, R.G.: Induced heteroploidy in mice: effect of deacethylmethyl colchicine on eggs at fertilization. Exp. Cell Res. 24, 615–618 (1961).
Fechheimer, N.S.: Causal basis of chromosome abnormalities. J. Reprod. Fertil. Suppl. 15, 79–98 (1972).
Fechheimer, N.S., Beatty, R.A.: Chromosomal abnormalities, and sex ratio in rabbit blastocysts. J. Reprod. Fertil. 37, 331–343 (1974).
Ferrier, P., Ferrier, S., Stalder, G., Buhler, E., Bamatter, F., Klein, D.: Congenital assymetry associated with diploid-triploid mosaicism and large satellites. Lancet 1964 I, 80–82.
Ford, C.E.: In: Cytogenetics of Cells in Culture (ed. R.J.C. Harris), p. 27. New York-London: Academic Press 1964.
Fraser, L.R., Dandekar, P. V.: The effect of aging on in vitro fertilization of rabbit eggs and subsequent embryonic development. J. exp. Zool. 184, 303–312 (1973).
Fujimoto, S., Pahlavan, N., Dukelow, W.R.: Chromosome abnormalities in rabbit preimplantation blastocysts induced by superovulation. J. Reprod. Fertil. 40, 177–181 (1974).
Graham, C.F.: Parthenogenetic mouse blastocysts. Nature (Lond.) 226, 165–166 (1970).
Graham, C.F.: Virus assisted fusion of embryonic cells. Karolinska Symp. Research Meth. Reproduct. Endocrinol. 3rd Symp. (ed. E. Diszfalusy), pp. 154–167 (1971).
Gulyas, B.J.: Electron microscopic observation on advanced stages of spontanous polyspermy in rabbit zygotes. Anat. Rec. 179, 285–296 (1974).
Gwatkin, R.B.L., Williams, D.T.: Heat sensitivity of the cortical granule protease from hamster eggs. J. Reprod. Fertil. 39, 153–155 (1974).
Hancock, J.L.: Polyspermy of pig ova. Anim. Prod. 1, 103–106 (1959).
Hamden, D.G.: Nuclear sex in triploid XXY human cells. Lancet 1961 II, 488.
Harper, M.J.K.: Factors influencing sperm penetration of rabbit eggs in vivo. J. exp. Zool. 173, 47–62 (1970).
Hunter, R.H.F.: Polyspermic fertilization in pigs during the luteal phase of the oestrus cycle. J. exp. Zool. 165, 451–460 (1967).
Hunter, R.H.F.: Local action of progesterone leading to polyspermic fertilization in pigs. J. Reprod. Fertil. 31, 433–444 (1972).
Hunter, R.H.F.: Polyspermic fertilization in pigs after tubal deposition of excessive numbers of spermatozoa. J. exp. Zool. 183, 57–64 (1973.
Hunter, R.H.F., Leglise, P.C.: Polyspermic fertilization following tubal surgery in pigs, with particular reference to the role of the istmus. J. Reprod. Fertil. 24, 233–246 (1971).
Iwamatsu, T., Chang, M.C.: Factors involved in the fertilization of mouse eggs in vitro. J. Reprod. Fertil. 26, 197–208 (1971).
Jerôme, H., Cathelineau, L., Bomsel-Helmreich, O.: Activités enzymatiques des cellules d’embryons de lapin diploides et triploides cultivés in vitro. VI Int. Congr. Anim. Reprod. Art, pp. 893–895. Paris: INSERM 1968.
Jerôme, H., Kamoun, P., Bomsel-Helmreich, O.: Enzymatic activities in diploid and triploid rabbit embryo fibroblasts in culture (in preparation 1976).
Jongbloet, P.H.A.: Mental and physical handicaps in connection with overripeness ovopathy. Acad. Proefschrift, Leiden, Holland (1971).
Kofoed-Johnsen, H.H., Pavlok, A., Fulka, J.: Effects of in vitro storage of spermatozoa on fertilizing efficiency and embryonic mortality in rabbits. Arsberetn Inst. Sterilitetsforsk K. Vet-og Landbohosk, 169 (1968).
Komar, A.: Parthenogenetic development of mouse eggs activated by heat-shock. J. Reprod. Fertil. 35, 433–443 (1973).
MacFeely, R.A.: Chromosome abnormalities in early embryos of the pig. J. Reprod. Fertil. 13, 579–585 (1967).
Martin, P.A., Shaver, E.L.: Sperm aging in utero and chromosomal anomalies in rabbit blastocyst. Develop. Biol. 28, 480–486 (1972).
Maurer, R.R., Whitener, R.H., Foote, R.H.: Relationship of in vivo gamete aging and exogenous hormones to early embryo development in rabbits. Proc. Soc. exp. Biol. Med. 131, 882–885 (1969).
Mittwoch, U.: DNA synthesis in cells grown in tissue culture from patients with mongolism. In: Mongolism Ciba Foundation Study Group NO 25, 51–61. London: Churchill 1967.
Mittwoch, U., Delhanty, J.D.A.: Inhibition of mitosis in human triploid cells. Nature (New Biol.) 238, 11–13 (1972).
Mittwoch, U., Delhanty, J.D.A., Beck, F.: Growth of differentiating testes and ovaries. Nature (Lond.) 224, 1323–1325 (1969).
Motlik, J., Fulka, J.: Fertilization and development in vivo of rabbit oocytes cultivated in vitro. J. Reprod. Fertil. 40, 183–187 (1974).
Niebuhr, E.: Triploidy in Man. Humangenetik 21, 103–125 (1974).
Nikawa, N., Kajii, T.: A triploid human abortus due to dispermy. Humangenetik 24, 261–264 (1974).
Niwa, K., Chang, M.C.: Fertilization in vitro of rat eggs as affected by the maturity of the females and the sperm concentration. J. Reprod. Fertil. 35, 577–580 (1973).
Niwa, K., Chang, M.C.: Optimal sperm concentration and minimal number of spermatozoa fpr fertilization in vitro of rat eggs. J. Reprod. Fertil. 40, 471–474 (1974).
Papiernik-Berkhauer, E.: Enfant triploïde né à terme et thérapeutique hormonale. Bull. Féd. Gynéc. Obstét. franç. 20, 248–250 (1968).
Paton, G.R., Silver, M.F., Allison, A.C.: Comparison of cell cycle time in normal and trisomic cells. Humangenetik 23, 173–182 (1974).
Piko, L.: La polyspermie chez les animaux. Ann. Biol. anim. Biochim. Biophys. 1, 323–383 (1961).
Piko, L., Bomsel-Helmreich, O.: Triploid rat embryos and other chromosomal deviants after cholchicine treatment and polyspermy. Nature (Lond.) 186, 737–738 (1960).
Pitkjanen, I. G.: Ovulation, fertilization and the early stages of embryonic development in pigs. Izv. Akad. Nauk Kazah. S.S.R., Ser. Biol. 31, 20–31 (1955).
Salisbury, G. W., Hart, R.G.: Gamete aging and its consequences. Biol. Reprod. Suppl. 2, 1–15 (1970).
Schmid, W., Vischer, D.: A malformed body with double aneuploidy and diploid-triploid mosaicism 48 XXYY/7l XXXYY. Cytogenetics 6, 145–155 (1967).
Schneider, E.L., Epstein, C.H.: Replication rate and lifespan of cultured fibroblasts in Down’s syndrome. Proc. Soc. exp. Biol. Med. 141, 1092–1094 (1972).
Shaver, E.L., Carr, D.H.: Chromosome abnormalities in rabbit blastocyst following delayed fertilization. Reprod. Fertil. 14, 415–420 (1967).
Snow, M.H.L.: Tetraploid mouse embryos produced by Cytochalasin B during cleavage. Nature (Lond.) 244, 513–514 (1973).
Stranzinger, G.: Untersuchungen über den Einfluß der in vitro Spermaaufbewahrung auf die Befruchtung und den Fruchttod sowie die Möglichkeit der Analyse dadurch bedingter chromosomaler Veränderungen beim Kaninchen. Dissertation Univ. Göttingen 1970.
Tarkowski, A.K., Witkowska, A., Nowicka, J.: Experimental parthenogenesis in the mouse. Nature (Lond.) 226, 162–165 (1970).
Tesh, J.M.: Effect of time of insemination and superoVUlation on fertilization in the rabbit. J. Endocr. 35, XXVIII–IX (1966).
Thibault, C.: Analysede la fécondation de l’oeuf de la truie après accouplement ou insémination artificielle. Ann. Zootechn. 8 (suppl.) 165–177 (1959).
Thibault, C.: Analyse comparée de la fécondation et de ses anomalies chez la brebis, la vache et la lapine. Ann. Biol. anim. Biochim. Biophys. 7, 5–23 (1967).
Vickers, A.D.: Delayed fertilization and chromosomal anomalies in mouse embryos. J. Reprod. Fertil. 20, 69–76 (1969).
Witkowska, A.: Parthenogenetic development of mouse embryos in vivo. I.Preimplantation development. II. Postimplantation development. J. Embryol. exp. Morphol. 59, 519–545 (1973).
Wroblewska, J.: Developmental anomaly in the mouse associated with triploidy. Cytogenetics 10, 199–207 (1971).
Yanagimachi, R., Chang, M.C.: In vitro fertilization of golden hamster ova. J. exp. Zool. 156, 361–369 (1964).
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Bomsel-Helmreich, O. (1976). Experimental Heteroploidy in Mammals. In: Gropp, A., Benirschke, K. (eds) Developmental Biology and Pathology. Current Topics in Pathology, vol 62. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66458-8_11
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DOI: https://doi.org/10.1007/978-3-642-66458-8_11
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