Abstract
The animal viruses with DNA genomes have been classified into five groups—parvoviruses, papovaviruses, adenoviruses, herpesviruses, and poxviruses—in order of increasing complexity (Melnick, 1974). Each of these virus groups have unique features which provide favorable experimental material for the investigator. The papovaviruses and adenoviruses have been especially useful in the study of DNA structure and replication. The availability of large quantities of viral DNA and the comparatively small genome size of these viruses have permitted experimental approaches leading to a detailed understanding of the primary (Dahr et al., 1974a, b; Fiers et al., 1974; Roberts et al., 1974), secondary, and tertiary (Vinograd and Lebowitz, 1966) structure of these DNA molecules. Restriction enzymes have been employed to generate defined fragments of these genomes which in turn have been used to study DNA replication and transcription and to localize viral mutants on the physical map of these genomes (Tables 2 and 3). With both the adenoviruses and papovaviruses the outlines of a DNA replication scheme are now available, the replicative intermediates have been visualized and several viral and cellular functions involved in DNA replication have been characterized (Levine, 1974).
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References
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Levine, A.J., van der Vliet, P.C., Sussenbach, J.S. (1976). The Replication of Papovavirus and Adenovirus DNA. In: Arber, W., et al. Current Topics in Microbiology and Immunology. Current Topics in Microbiology and Immunology / Ergebnisse der Mikrobiologie und Immunitätsforschung, vol 73. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66306-2_3
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