Abstract
Sodium nitroprusside is being widely used for the production of hypotension in neurosurgery. KEANEY et al (1) have shown in animal investigations that after both halothane and sodium nitroprusside-induced hypotension, autoregulation of cerebral blood flow is impaired. There appears to be a partial recovery of autoregulation 90 minutes after hypotension induced with sodium nitroprusside, but not at this time after halothane-induced hypotension.
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References
KEANEY, N.P., MCDOWALL, D.G., TURNER, J.M., LANE, J.R., OKUDA, Y., PICKERODT, V.W.A., CORONEOS, N.J.: Cerebral blood flow autoregulation, cerebrospinal fluid acid-base parameters and profound hypotension induced by sodium nitroprusside and deep halothane anaesthesia. In: Stroke (Proc. 6th Int. CBF Symp., Philadelphia, 1973). In press.
JENNETT, W.B., BARKER, J., FITCH, W., MCDOWALL, D.G.: Effect of anaesthesia on intracranial pressure in patients with space-occupying lesions. Lancet, i, 61–64 (1969).
LEECH, P., BARKER, J., FITCH, W.: Changes in intracranial pressure and systemic arterial pressure during the termination of anaesthesia. Brit. J. Anaesth. In press.
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© 1975 Springer-Verlag Berlin Heidelberg
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Turner, J.M., Powell, D., Gibson, R.M., McDowall, D.G. (1975). The Effects of Sodium Nitroprusside on Intracranial Pressure and Autoregulation. In: Lundberg, N., Pontén, U., Brock, M. (eds) Intracranial Pressure II. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66086-3_74
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DOI: https://doi.org/10.1007/978-3-642-66086-3_74
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