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Cerebral Blood Volume in Dementia

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Intracranial Pressure II

Abstract

Cerebral blood flow (CBF) and metabolism are reduced in dementia. It is assumed that CBF is reduced as a consequence of the decreased metabolism. This synergism between CBF and metabolism is thought to be mediated by metabolically generated hydrogen ions acting on cerebral resistance vessels. As metabolism falls less hydrogen ion is generated; vasoconstriction occurs leading to increased cerebrovascular resistance and a fall in CBF. If this is true, then cerebral blood volume (CBV) should be reduced in patients with dementia. To test this hypothesis CBV, CBF, and cerebral oxygen consumption (CMRO2) were measured in 29 patients with dementia utilizing radio-active oxygen-15 and employing residue detection.

This work was supported by U.S. PHS Grant No. Pol HL13851, by Research Grant RR 00396 from the Division of Research Ressources of the NIH, by Teacher-Inverstigator Award 1 Fll HS11059 (Dr. Raichle), Grant No. POl NSO 6833 from the National Institute of Neurological Disease and Stroke, and by NIH Training Grants No. TO1-NSO551 and No. TO1-GM-01747.

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References

  1. Ter-Pogossian, M.M., Eichling, J.O., Davis, D.O., Welch, M.J.: The measure in vivo of regional cerebral oxygen utilization by means of oxyhemoglobin labelled with radioactive oxygen-15. J. Clin. Invest. 49, 381–391 (1970).

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  2. Phelps, M.E., Grubb, R.L.J., Ter-Pogossian, M.M.: In vivo regional cerebral blood volume by X-ray fluorescence: validation of method. J. Appl. Physiol. 35, 741–747 (1973).

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Authors
  1. Marcus E. Raichle
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  2. John O. Eichling
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  3. Mokhtar H. Gado
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  4. Robert L. Grubb Jr.
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  5. Michel M. Ter-Pogossian
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Editors and Affiliations

  1. Neurochirurgische Klinik, Medizinische Hochschule Hannover, Hannover-Kleefeld, W. Germany

    M. Brock

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© 1975 Springer-Verlag Berlin Heidelberg

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Raichle, M.E., Eichling, J.O., Gado, M.H., Grubb, R.L., Ter-Pogossian, M.M. (1975). Cerebral Blood Volume in Dementia. In: Lundberg, N., Pontén, U., Brock, M. (eds) Intracranial Pressure II. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66086-3_31

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  • DOI: https://doi.org/10.1007/978-3-642-66086-3_31

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-66088-7

  • Online ISBN: 978-3-642-66086-3

  • eBook Packages: Springer Book Archive

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