Abstract
During the last ten years the number of digestive enzymes bound to the brush border membrane of intestinal mucosal epithelial cells (5, 7, 9) and the number of substrates translocated across the microvillus membrane by Na+-dependent transport systems has increased considerably (2, 5, 9). Evidence is accumulating that digestive and absorptive functions of the small intestine cannot be expressed by the simple concept that enzymatic digestive action and membrane transport are sequential, but otherwise separate processes (5, 7, 8, 14, 15). On the contrary, both processes are closely integrated and are achieving an efficient cooperation, enhanced in addition by spatial organization of the functional components of these processes (5, 6, 7).
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References
ALVARADO, F., CRANE, R. K.: Phlorizin as a competitive inhibitor of the active transport of sugars by hamster small intestine, in vitro. Biochim. Biophys. Acta 56, 170–178(1962).
CASPARY, W. F., CRANE, R. K.: Active transport of myo-inositol and its relation to the sugar transport system in hamster small intestine. Biochim. Biophys. Acta 203, 308–316(1970).
CASPARY, W. F., STEVENSON, N. R., CRANE, R. K.: Evidence for an intermediate step in carrier-mediated sugar translocation across the brush border membrane of hamster small intestine. Biochim. Biophys. Acta 193, 168–178 (1969).
CRANE, R. K.: Absorption of sugars. In Handbook of Physiology, Section 6: Alimentary Canal, Vol. III, C. F. Code (editor), American Physiological Society, Washington, D. C., 1968, p. 1323–1351.
CRANE, R. K.: Organisation der digestiv-absorptiven Funktion an der Membran des Bürstensaumes, In: Biochemische und klinische Aspekte der Zucker resorption, K. Rommel (editor), F. K. Schattauer Verlag, Stuttgart New York, 1970, p. 75–83.
CRANE, R. K.: Structural and functional organization of an epithelial cell brush border, In: Intracellular transport, edited by K. B. Warren, New York, Academic Press, 1967, Vol. V, p. 71–103.
CRANE, R. K.: A perspective of digestive-absorptive function. American J. of Clin. Nutrition 22, 242–248 (1969).
CRANE, R. K., Malathi, P., Caspary, W. F., Ramaswamy, K.: Evidence for a second glucose transport system in hamster small intestine specific for glucose released by brush border digestive enzymes. Federation Proceedings 29, 595 (abstract) (1970).
GARDNER, J. D., BROWN, M. S., LASTER, L.: The columnar epithelial cell of the small intestine: digestion and transport. New England J. of Medicine 283, 1196–1202 (1970).
GRAY, G. M., INGELFINGER, F. J.: Intestinal absorption of sucrose in man: interrelation of hydrolysis and monosaccharide product absorption. J. Clin. Investigation 45, 388–398(1965).
HAMILTON, J. D., MCMICHAEL, H. B.: Role of the microvillus in the absorption of disaccharides. The Lancet II, 154–155(1968).
LYON, I., CRANE, R. K.: Studies on transmural potential in vitro in relation to intestinal absorption. 1. Apparent Michaelis constants for Na+-dependent sugar transport. Biochim. Biophys. Acta 112, 278–286(1966).
MILLER, D., CRANE, R. K.: Digestive function of the epithelium of the small intestine: 1. An intracellular locus of disaccharide and sugar phosphate hydrolysis. Biochim. Biophys. Acta 52, 281–293(1961).
PARSONS, D.S., PRITCHARD, J.S.: Relationship between disaccharide hydrolysis and sugar transport in amphibian small intestine. J. Physiology 212, 299–319(1971).
PARSONS, D.S.: Black box models of intestinal mucosal cellular function. In: Intestinal transport of electrolytes, amino acids and sugars. W.McD. Armstrong (editor), Charles Thomas Publ., Springfield, Illinois, 1971, p. 24–51.
RAMASWAMY, K., MALATHI, P., CRANE, R. K.: The direct transport of glucose from disaccharides by in vitro hamster small intestine. Federation Proceedings 30, 538 (abstract) (1971).
SCHULTZ, S. G., ZALUSKY, R.: Ion transport in isolated rabbit ileum. II. The Interaction between active sodium and sugar transport. J. General Physiology 47, 1043–1059(1964).
SEMENZA, G., TOSI, R., VALLOTON-DELACHAUX, M. C., Mühlhaupt, E.: Sodium activation of human intestinal sucrase and its possible significance in the enzymatic organization of brush borders. Biochim. Biophys. Acta 89, 109–116 (1964).
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Caspary, W.F. (1972). Evidence for a Sodium-Independent Transport System for Glucose Derived from Disaccharides. In: Heinz, E. (eds) Na-linked Transport of Organic Solutes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65404-6_11
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DOI: https://doi.org/10.1007/978-3-642-65404-6_11
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