Abstract
Hamsters are exposed to selected lung burdens of plutonium contained in 10 µm diameter inert microspheres of ZrO2 ceramic. Injected into the jugular vein, the microspheres lodge quantitatively in the lung capillaries and remain immobile for the life of the hamster. Distribution through the lung is essentially random but shows a systematic variation through a factor of about 2 from lobe to lobe.
The specific activity of the microspheres is varied from 0.01 to 100 pCi per sphere, spanning the range of respirable particles of 238PuO2 and 239PuO2. The number of spheres per animal varies from 2,000 to 1,000,000 and the lung burden from 0.1 to 1000 nCi. The fraction of lung irradiated ranges from 0.01 to 0.98, and the calculated median dose rate to the tissue exposed is from 0.5 to 700 krad per year. The spheres are completely inert and provoke no foreign-body reactions. In contrast to most methods of exposure by inhalation or insufflation, the radiation is delivered essentially 100% to the lung. Because of the immobility and uniformity of the microspheres, the distribution of energy deposition can be calculated with precision on a microscale.
The most surprising result has been the minimal biological damage even after exposure times in excess of 2 years. Not only are gross effects (such as pneumonitis, hyperplasia, fibrosis, and tumors) insignificant, but little or no deterioration of parenchymal microstructure has been observed.
This work is being performed under the auspices of the U.S. Atomic Energy Commission.
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References
ALBERT, R.E., BURNS, F.J., HEIMBACH, R.D.: Radiation skin tumorigenesis in the rat. Radiation Res. 30, 590–599 (1967).
DEAN, P.N., LANGHAM, W.H.: Tumorigenicity of small highly radioactive particles. Health Phys. 16, 79–84 (1969).
FULWYLER, M.J., PERRINGS, J.D., CRAM, L.S.: Production of uniform microspheres. Rev. Sci. Instr. 44, 204–206 (1973).
GEESAMAN, D.P.: An analysis of the carcinogenic risk from an insoluble alpha-emitting aerosol deposited in deep respiratory tissue. University of California Radiation Laboratory, report UCRL-50387 and Addendum (1968).
HOLLAND, L.M., DRAKE, G.A., LONDON, J.E., WILSON, J.S.: Intravenous injection with a pulsed dental cleaning device. Laboratory Animal Sci. 21, 913–915 (1971).
LITTLE, J.B., GROSSMAN, B.N., O’TOOLE, W.F.: Respiratory carcinogenesis in hamsters induced by Po-210 alpha radiation and benzo (a) — pyrene. In: Morphology of Experimental Respiratory Carcinogenesis (P. Nettesheim, M.G. Hanna, Jr., J.W. Deatherage, Jr., eds), pp. 383–394. AEC Symposium Series no. 21. Oak Ridge, Tennessee: U.S. Atomic Energy Commission, Division of Technical Inf. 1970.
LITTLE, J.B., GROSSMAN, B.N., O’TOOLE, W.F.: Factors influencing the induction of lung cancer in hamsters by intratracheal administration of Po-210. In: Radionuclide Carcinogenesis (C.L. Sanders, R.H. Busch, J.E. Ballou, D.D. Mahlum, eds), pp. 119–137. USAEC Division of Technical Information, Oak Ridge (1973).
PEREZ, L.J., Jr., COLEMAN, J.R.: Considerations of a tumor probability function and micro-dosimetry for the deep lung. In: Report to Space Nuclear Systems Division, USAEC report NUS-596, Part II (1969).
RICHMOND, C.R., VOELZ, G.L.: Annual report of the biological and medical research group of the LASL Health Division, January through December 1971. Los Alamos Scientific Laboratory report LA-4923-PR (1972). (Available from the National Technical Information Service, U.S. Department of Commerce, 5285 Port Royal Road, Springfield, Va. 22151).
RICHMOND, C.R., VOELZ, G.L.: Annual report of the biological and medical research group of the LASL Health Division, January through December 1972. Los Alamos Scientific Laboratory report LA-5227-PR (1973). (Available from the National Technical Information Service, U.S. Department of Commerce, 5285 Port Royal Road, Springfield, Va. 22151).
RICHMOND, C.R., SULLIVAN, E.M.: Annual report of the biomedical and environmental research program of the LASL Health Division, January through December 1973. Los Alamos Scientific Laboratory report LA-5633-PR (1974). (Available from the National Technical Information Service, U.S. Department of Commerce, 52 85 Port Royal Road, Springfield, Va. 22151).
Task Group on Lung Dynamics: Deposition and retention models for internal dosimetry of the human respiratory tract. Health Phys. 12, 173–207 (1966).
UNDERWOOD, E.E.: Quantitative Sterology, p. 84. Reading, Mass.: Addison-Wesley Pub. Co. 1970.
WEIBEL, E.R.: Morphometry of the Human Lung, p. 86. Berlin-Göttingen-Heidelberg: Springer 1963.
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Anderson, E.C., Holland, L.M., Prine, J.R., Richmond, C.R. (1974). Lung Irradiation with Static Plutonium Microspheres. In: Karbe, E., Park, J.F. (eds) Experimental Lung Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61939-7_41
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DOI: https://doi.org/10.1007/978-3-642-61939-7_41
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