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Studies on Collagen Peptidases

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Connective Tissues

Abstract

Collagenolytic enzymes like collagenases and collagenpeptidases take part in the collagen turnover. As collagenases — especially collagen-proteases — split native collagen, collagenolytic activity was determined by using 14C-labelled native collagen for a substrate (Woods and Nichols, 1965; Nagai et al., 1966; Jeffrey and Gross, 1967; Eisen et al., 1968; Lazarus et al., 1968; Harris et al., 1969; Keiditsch and Strauch, 1970, Vaes, 1971).

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References

  • Aer, J.: Action of some hormones on the collagenolytic activities of rat bone cells. Ann. Med. exp. Biol. Fenn. 49, 9–12 (1971).

    PubMed  CAS  Google Scholar 

  • Bankowski, E., Galasinski, W.: Tissue collagenolytic enzymes. Postepy Biochem. 16, 553–563 (1953).

    Google Scholar 

  • Boas, N: Methods for the determination of hexosamines in tissues. J. biol. Chem. 204, 553 (1953).

    PubMed  CAS  Google Scholar 

  • Chvapil, M., Kobrle, V.: Changes in proline and hydroxyproline in collagen during the development of rats. Experientia (Basel) 17, 226–229 (1961).

    Article  CAS  Google Scholar 

  • Cutroneo, K.R., Fuller, G.C.: Circadian rhythm of rat liver and lung collagenase activity. Life Sci., Pt. 2. Biochem. Gen. Molec. 10, 395–400 (1971).

    CAS  Google Scholar 

  • Eisen, A.Z., Bauer, E.A., Jeffrey, J.J.: Human skin collagenase. The role of serum alpha-globulins in the control of activity in vivo and in vitro. Proc. nat. Acad. Sci. (Wash.) 68, 248–251 (1971).

    Article  CAS  Google Scholar 

  • Eisen, A.Z., Jeffrey, J.J., Gross, J.: Human skin collagenase. Isolation and mechanism of attack on the collagen molecule. Biochim. biophys. Acta (Amst.) 151, 637–645 (1968).

    Google Scholar 

  • Elster, S.K., Lowry, E.L.: Collagen content of guinea pig tissues. Proc. Soc. exp. Biol. (N.Y.) 75, 127 (1950).

    CAS  Google Scholar 

  • Espey, L.L., Rondell, P.: Estimation of mammalian collagenolytic activity with a synthetic substrate. J. appl. Physiol. 23, 757–761 (1967).

    PubMed  CAS  Google Scholar 

  • Fishman, W.H.: β-Glucuronidase. In: H.U. Bergmeyer (Ed.): Methoden der enzymatischen Analyse, Vol. I, p. 891–894. Weinheim: Verlag Chemie 1970.

    Google Scholar 

  • Friberg, O.: Effect of adrenocortical hormones on hydroxyproline concentration of heart and skeletal muscle. An experimental investigation with mice. Ann. Med. exp. Biol. Fenn. 35., Suppl. 8, 1–70 (1957).

    PubMed  CAS  Google Scholar 

  • Götze, W., Gries, G., Lindner, J.: Beitrag zum Kollagenabbau im menschlichen Zahnfleisch. Dtsch. zahnärztl. Z. 25, 492–495 (1970).

    Google Scholar 

  • Grasedyck, K., Ropohl, D., Szarvas, F., Lindner, J.: Kollagenpeptidase-aktivität menschlicher Seren bei Leberzirrhose. Klin. Wschr. 49, 163–164 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Gries, G., Grasedyck, K.: Über spezifische Kollagenasen in Organen des Magen-Darmtraktes. Verh. Dtsch. Ges. Path. 53, 205–209 (1969).

    CAS  Google Scholar 

  • Gries, G., Lindner, J.: Zur Frage des Abbaues von Kollagen. Klin. Wschr. 38, 406–407 (1960).

    Article  PubMed  CAS  Google Scholar 

  • Gries, G., Lindner, J.: Untersuchungen über den Kollagenabbau bei akuten Entzündungen. Z. Rheumaforsch. 20, 122–125 (1961).

    PubMed  CAS  Google Scholar 

  • Gries, G., Lindner, J.: Zur Frage des Kollagenabbaues bei verschiedenen Formen experimenteller Entzündungen. Z. Rheumaforsch. 22, 439–443 (1963).

    PubMed  CAS  Google Scholar 

  • Gries, G., Strauch, L.: Normalwerte kollagenolytischer Enzyme in menschlichem Serum. Klin. Wschr. 48, 441–442 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Gries, G., Strauch, L., Grasedyck, K., Lindner, J.: Die Bestimmung von Kollagenpeptidasen in tierischen Geweben. Z. Rheumaforsch. 31, 93–98 (1972).

    PubMed  CAS  Google Scholar 

  • Gross, J., Lapiere, C.M.: Collagenolytic activity in amphibian tissues: a tissue culture assay. Proc. nat. Acad. Sci. (Wash.) 48, 1014–1022 (1962).

    Article  CAS  Google Scholar 

  • Hakim, A.W.: On the collagenolytic activity of the mammalian pancreas. Enzymologia 30, 299–329 (1966).

    PubMed  CAS  Google Scholar 

  • Harris, E.D., Cohen, G.L., Krane, S.M.: Synovial collagenase: its presence in culture from joint disease of diverse etiology. Arthr. and Rheum. 12, 92–102 (1969).

    Article  Google Scholar 

  • Hauss, W.H., Junge-Hülsing, G., Gerlach, U.: Die unspezifische Mes- enchymreaktion. Zur Pathogenese der reaktiven Mesenchymerkrankungen. Stuttgart: Thieme 1968.

    Google Scholar 

  • Heidrich, H.-G., Prokopovä, D., Hannig, K.: The use of synthetic substrates for the determination of mammalian collagenases. Is collagenolytic activity present in mitochondria? Hoppe-Seylers Z. physiol. Chem. 350, 1430–1436 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Houck, J.C.: Response of the connective tissue to Cortisol or salicylates. Arthr. and Rheum. 111 (1962).

    Google Scholar 

  • Jeffrey, J.J., Gross, J.: Isolation and characterization of a mammalian collagenolytic enzyme. Fed. Proc.,26, 670 (1967).

    Google Scholar 

  • Junge-Hülsing, G.: Untersuchungen zur Pathophysiologie des Bindegewebes. Habil.-Schrift Münster 1963.

    Google Scholar 

  • Keiditsch, E., Strauch, L.: Peptidase and collagenase activities in the invasion zones of tumors of the breast. In: E.A. Balazs (Ed.): Chemistry and Molecular Biology of the Intercellular Matrix, Vol. III, p. 1671–1674. London-New York: Academic Press 1970.

    Google Scholar 

  • Kirschke, H., Hanson, H.: Untersuchungen über den Kollagenabbau durch Rattenorgane. Differenzierung und Charakterisierung Prolinpeptid-spaltender Enzyme. Hoppe-Seylers Z. physiol. Chem. 350, 1437–1448 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Kivirikko, K.I.: Hydroxyproline-containing fractions in normal and cortisone-treated chick embryos. Acta physiol. scand. Suppl. 219 (1963).

    Google Scholar 

  • Kobrle, V., Chvapil, M.: Isolation of peptidase containing hydroxyproline from animal tissues. Nature (Lond.) 190, 900–910 (1961).

    Article  Google Scholar 

  • Kobrle, V., Chvapil, M.: The amount of ultrafiltrable and collagen- bound hydroxyproline in different organs of the rat during aging. Physiol. bohemoslov. 11, 243–248 (1962).

    PubMed  CAS  Google Scholar 

  • Kowalewski, K.: Effect of cortisone on hydroxyproline of liver, gastric tissue, skin and bone of male rats. Acta endocr. (Kbh.) 38, 427–431 (1961).

    CAS  Google Scholar 

  • Langer, E., Keiditsch, E., Strauch, L., Hannig, K.: Die Kollagenaseaktivität im carcinoma solidum simplex mammae. Verh. Dtsch. Ges. Path. 52, 438–440 (1968).

    CAS  Google Scholar 

  • Lazarus, G.S., Decker, J.L., Oliver, C.H., Daniels, J.R., Multz, C.V., Fullmer, H.M.: Collagenolytic activity of synovium in rheumatoid arthritis. N. Engl. J. Med. 279, 914–919 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Lindner, J.: Untersuchungen am Bindegewebe. Habil.-Schrift, Univ. Hamburg 1957a.

    Google Scholar 

  • Lindner, J.: Vergleichende histochemische und papierchromatographische Untersuchungen bei Entzündungsvorgängen der Haut. Arch. klin. exp. Derm. 206, 379–394 (1957b).

    Article  PubMed  CAS  Google Scholar 

  • Lindner, J.: Der cytostatische Einfluß von Bindegewebsbausteinen. Verh. Dtsch. Ges. Path. 45, 207–213 (1961).

    CAS  Google Scholar 

  • Lindner, J.: Histochemie der Atherosklerose. In: G. Schettler (Hrsg.): Arteriosklerose, S. 61–87. Stuttgart: Thieme 1961.

    Google Scholar 

  • Lindner, J.: Über die Synthese der organischen Interzellularsubstanz in Knorpel und Knochen. Verh. Dtsch. Ges. Path. 47, 100–102 (1963).

    Google Scholar 

  • Lindner, J.: The histochemistry of atherosclerosis. In: F.G. Schettler, G.S. Boyd (Ed.): Atherosclerosis, p. 73–140. Amsterdam: Elsevier 1969a.

    Google Scholar 

  • Lindner, J.: Metabolism of granulation tissue and other connective tissues. Scand. J. clin. Lab. Invest. (Suppl.) 108, 12–13 (1969b).

    Google Scholar 

  • Lindner, J., Gries, G., Freytag, G., Kind, J.: Stoffwechseluntersuchungen an der atherosklerotischen Gefäßwand. Verh. Dtsch. Ges. Path. 51, 228–246 (1967).

    CAS  Google Scholar 

  • McGavack, T.H., Kao, K.T.: The influence of age and sex on the soluble collagen, insoluble collagen and elastin of rat tissues. Exp. Med. Surg. 18, 104 (1960).

    PubMed  CAS  Google Scholar 

  • Mitchell, W.M.: Pseudocollagenase: a protease from Clostridium histolyticum. Biochim. biophys. Acta (Amst.) 159, 554–557 (1968).

    CAS  Google Scholar 

  • Nagai, Y.: Collagenase digestion of collagen. J. Biochem. (Tokyo) 50, 486–492 (1961).

    CAS  Google Scholar 

  • Nagai, Y., Lapiere, C.M., Gross, J.: Tadpole collagenase. Preparation and purification. Biochemistry 5, 3123–3130 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Neuman, R.E., Logan, M.A.J.: The determination of collagen and elastin in tissues. J. biol. Chem. 186, 549–556 (1950).

    PubMed  CAS  Google Scholar 

  • Platt, D., Stein, Z.: Untersuchungen zum katabolen Mucopolysaccharid-Protein-Stoffwechsel in menschlichen Organen. Z. klin. Chem. 7, 374 (1969).

    CAS  Google Scholar 

  • Platt, D.: Altersabhängige Aktivitätsänderungen lysosomaler Enzyme (Glykosaminoglykan-Hydrolasen) in Serum und Organen des Menschen. Dtsch. med. Wschr. 95, 634 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Platt, D.: Biochemische Aspekte zum Altern der Interzellularsubstanz, akt. gerontol. 1, 81 (1971).

    Google Scholar 

  • Platt, D.: Nachweis, Reinigung und Eigenschaften einer Peptidyl-Peptid-Hydrolase (Kollagenase) aus Leber und Milz des Kaninchens. Z. ges. exp. Med. 150, 185–193 (1969).

    Article  CAS  Google Scholar 

  • Platt, D.: Nachweis einer Peptidyl-Peptid-Hydrolase (Kollagenase?) in der Aortenwand des Schweins. Klin. Wschr. 48, 1420–1421 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Sakata, R.: Biochemical studies on the collagen metabolism. II. Collagen metabolism of the skin in some pathological states. Kumamoto med. J. 13, 41–53 (1960a).

    CAS  Google Scholar 

  • Sakata, R.: Biochemical studies on the collagen metabolism. III. Collagen metabolism in healing wounds. Kumamoto med. J. 13, 54–72 (1960b).

    CAS  Google Scholar 

  • Schaub, M.C.: Qualitative and quantitative changes of collagen in parenchymatous organs of the rat during aging. Gerontologia (Basel) 8, 114 (1963).

    Article  CAS  Google Scholar 

  • von Schweinitz, H.A., Lindner, J.: Histochemische und fermenthisto-chemische Untersuchungen am Geschwulstgewebe. II. Mitt.: Untersuchungen des Aszitestumor-Proteolyse. Frankf. Z. Path. 69, 667–678 (1959).

    Google Scholar 

  • Smith, Q.T.: Quantitative studies on cutaneous collagen, procollagen and hexosamine in normal and cortisone treated rats. J. invest. Perm. 38, 65–68 (1962a).

    CAS  Google Scholar 

  • Smith, Q.T.: Effects of cortisone administration on cutaneous collagen and hexosamine in rats of various ages. J. invest. Derm. 39, 291–324 (1962b).

    Google Scholar 

  • Sobel, H., Gabay, S., Johnson, C., Hassan, B.: Carcass nitrogen and the hexosamine-collagen ratio of skin following starvation and cortisone administration in rats and guinea pigs. Metabolism 8, 180–184 (1959).

    PubMed  CAS  Google Scholar 

  • Sobel, H., Marmorston, J.: The effect of cortisone on the collagen and hexosamine content of the skin and femurs of one-year-old rats. Endocrinology 55, 21–27 (1954).

    Article  PubMed  CAS  Google Scholar 

  • Stegemann, H.: Mikrobestimmung von Hydroxyprolin mit Chloramin-T und p-Dimethylaminobenzaldehyd. Hoppe-Seylers Z. physiol. Chem. 311, 41–45 (1958).

    Article  PubMed  CAS  Google Scholar 

  • Strauch, L.: Ultramikro-Methode zur Bestimmung des Stickstoffes in biologischem Material. Z. klin. Chem. 3, 165–167 (1965).

    CAS  Google Scholar 

  • Strauch, L.: Kollagenasen aus Zellen des Menschen und höher entwickelter Tiere. Mitt. Max-Planck-Ges. 1, 40–56 (1968).

    Google Scholar 

  • Strauch, L.: Peptidyl-peptide hydrolase (collagenase) in cells of higher animals. In: E.A. Balazs (Ed.): Chemistry and Molecular Biology of the Intracellular Matrix, Vol. III, p. 1675–1682. London- New York: Academic Press 1970.

    Google Scholar 

  • Strauch, L., Vencelj, H.: Collagenases in mammalian cells. Hoppe-Seylers Z. physiol. Chem. 348, 465–468 (1967).

    CAS  Google Scholar 

  • Strauch, L., Vencelj, H., Hannig, K.: Kollagenasen in Zellen höher entwickelter Tiere. Hoppe-Seylers Z. physiol. Chem. 349, 171–178 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Vaes, G.: A latent collagenase released by bone and skin explants in culture. Biochem. J. 123, 23–24 (1971).

    Google Scholar 

  • Woessner, J.F., Boucek, R.J.: Connective tissue development in subcutaneously implanted polyvinyl sponges. Arch. Biochem. 93, 85–94 (1961).

    Article  PubMed  CAS  Google Scholar 

  • Woods, J.F., Nichols, G.: Distribution of collagenase in rat tissues. Nature 208, 1325–1326 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Wünsch, E., Heidrich, H.-G.: Darstellung von Prolinpeptiden. III. Ein neues Substrat zur Bestimmung der Kollagenase. Hoppe-Seylers Z. physiol. Chem. 332, 300–304 (1963).

    Article  Google Scholar 

  • Wünsch, E., Jaeger, E., Schoensteiner-Altmann, G.: Zur Bestimmung der Koüagenase mit N-((Azulen-4-yl) acetyl-) peptiden. Hoppe-Seylers Z. physiol. Chem. 352, 1560–1567 (1971).

    Article  PubMed  Google Scholar 

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Authors
  1. J. Lindner
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  2. K. Grasedyck
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  3. G. Prinz
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  4. J. Grade
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  5. H. Kölln
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Editors and Affiliations

  1. Medizinische Poliklinik, Hannover-Kleefeld, Germany

    Reinhard Fricke  & Fritz Hartmann  & 

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Lindner, J., Grasedyck, K., Prinz, G., Grade, J., Kölln, H. (1974). Studies on Collagen Peptidases. In: Fricke, R., Hartmann, F. (eds) Connective Tissues. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61932-8_23

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  • DOI: https://doi.org/10.1007/978-3-642-61932-8_23

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  • Print ISBN: 978-3-642-61934-2

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