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The Vascular Endothelium: Interactions with Hemostatic Mechanisms (Platelets, Coagulation, Fibrinolysis)

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Unstable Angina

Abstract

The vascular endothelium, which lines all blood vessels like a continuous sheet, must nowadays be regarded as a rather large tissue compartment of particular functional importance. With respect to its size, one should realize that in a person with 70 kg body weight the endothelial mass amounts to about 1000–1500 g, comparable to the mass of the liver [10]. Even more impressive is the size of the endothelial surface, estimated to be about 800–1000 m2 [47]. This huge surface is in continuous contact with the 5–6 l of circulating blood, or, in other words, 5–6 ml of blood are on the average exposed to an endothelial area of 0.8–1 m2. As an interesting consequence, one can calculate that the mean thickness of the blood film covering the endothelial surface amounts to about 5μm, a value corresponding to the thickness of two red blood cells. These figures are merely intended to illustrate that intimate interactions of the streaming blood and its constituents with the endothelium are readily possible.

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Author information

Authors and Affiliations

  1. Physiologisches Institut der Universität, Pettenkoferstrasse 12, 8000, München 2, West Germany

    B. F. Becker

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  1. E. Gerlach
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  2. B. F. Becker
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Editors and Affiliations

  1. Universitätskrankenhaus Eppendorf — Kardiologie, Martinistraße 52, 2000, Hamburg 20, Germany

    Walter Bleifeld Professor Dr.  & Christian W. Hamm Privatdozent Dr.  & 

  2. Department of Medicine, Brigham and Women’ Hospital, Harvard Medical School, 75 Francis Street, 02115, Boston, MA, USA

    Eugene Braunwald Professor Dr.

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© 1990 Springer-Verlag Berlin Heidelberg

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Gerlach, E., Becker, B.F. (1990). The Vascular Endothelium: Interactions with Hemostatic Mechanisms (Platelets, Coagulation, Fibrinolysis). In: Bleifeld, W., Hamm, C.W., Braunwald, E. (eds) Unstable Angina. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61288-6_1

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  • DOI: https://doi.org/10.1007/978-3-642-61288-6_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64778-9

  • Online ISBN: 978-3-642-61288-6

  • eBook Packages: Springer Book Archive

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