Abstract
During the development of an organism, there are periods which can be critical for its normal maturation. Vulnerable periods during the ontogenesis of the central nervous system (CNS) can be roughly divided into two main courses of events in the development of the brain. The first includes its early development, a period during which the general shape of the adult brain is acquired and the spongioblasts and neuroblasts, precursors of glia cells and neurons, respectively, multiply. Interference by xenobiotics during this period can cause malformation of the brain.
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Ahlbom, J, Fredriksson, A and Eriksson, P (1994) Neonatal exposure to a type-I pyrethroid (bioallethrin) induces dose-response changes in brain muscarinic receptors and behaviour in neonatal and adult mice. Brain Res. 645, 318–324
Bartus, RT, Dean m, RL, Beer, B and Lippa, AS (1982) The cholinergic hypothesis of geriatric memory dysfunction. Science 217, 408–417
Beani, L, Bianchi, C, Ferraro, L, Nilsson, L, Nordberg, A, Romanelli, L, Spalluto, P, Sundwall, A and Tanganelli, S (1989) Effect of nicotine on the release of acetylcholine and amino acids in the brain. In: Nordberg, A, Fuxe, K, Holmstedt, B and Sundwall, A (eds) Nicotinic receptors in the CNS. Their role in synaptic transmission. Elsevier, Prog. Brain Res. 79, 149–155
Bolles, RG and Woods, PJ (1964) The ontogeny of behaviour in the albino rat. Anim. Behav. 12, 427–441
Campbell, BA, Lytle, LD and Fibiger, HC (1969) Ontogeny of adrenergic arousal and cholinergic inhibitory mechanisms in the rat. Science 166, 635–637
Coyle, JT and Yamamura, HI (1976) Neurochemical aspects of the ontogenesis of cholinergic neurons in the rat brain. Brain Res. 118, 429–440
Davison, AN and Dobbing, J (1968) Applied Neurochemistry, Blackwell, Oxford pp. 178–316
Drachman, DA (1977) Cognitive function in man. Does the cholinergic system have a special role? Neurology 27, 783–790
Eriksson, P, Ahlbom, J and Fredriksson, A (1992) Exposure to DDT during a defined period in neonatal life induces permanent changes in brain muscarinic receptors and behaviour in adult mice. Brain Res. 582, 277–281
Eriksson, P and Darnerud, PO (1985) Distribution and retention of some chlorinated hydrocarbons and a phthalate in the mouse brain during the pre-weaning period. Toxicology 37, 189–203
Eriksson, P and Fredriksson, A (1991) Neurotoxic effects of two different pyrethroids, bioallethrin and deltamethrin, on immature and adult mice: Changes in behavioral and muscarinic receptor variables. Toxicol. Appl. Pharmacol. 108, 78–85
Eriksson, P and Fredriksson, A (1995) Developmental neurotoxicity of four ortho-substituted poly chlorinated biphenyls in the neonatal mouse, (submitted for publ.)
Eriksson, P, Johansson, U, Ahlbom, J and Fredriksson, A (1993) Neonatal exposure to DDT induces increased susceptibility to pyrethroid (bioallethrin) exposure at adult age. - Changes in cholinergic muscarinic receptor and behavioural variables. Toxicology 77, 21–30
Eriksson, P and Nordberg, A (1986) The effects of DDT, DDOH-palmitic acid, and a chlorinated paraffin on muscarinic receptors and the sodium-dependent choline uptake in the central nervous system of immature mice. Toxicol. Appl. Pharmacol. 85, 121–127
Eriksson, P and Nordberg, A (1990) Effects of two pyrethroids, bioallethrin and d eltamethrin, on subpopulations of muscarinic and nicotinic receptors in the neonatal mouse brain. Toxicol. Appl. Pharmacol. 102, 456–463
Falkeborn, Y, Larsson, C, Nordberg, A and Slanina, P (1983) A comparison of the regional ontogenesis of nicotine- and muscarine-like binding sites in the mouse brain. Int. J. Dev. Neurochem. 1, 187–190
Fiedler, EP, Marks, MJ and Collins, AC (1987) Postnatal development of cholinergic enzymes and receptors in mouse brain. J. Neurochem. 49, 983–990
Johansson, U, Fredriksson, A and Eriksson, P (1995) Bioallethrin causes permanent changes in behavioural and cholinergic muscarinic receptor variables in adult mice exposed neonatally to DDT. Eur. J. Pharmacol. 293, 159–166
Karczmar, AG, (1975) Cholinergic influences on behaviour. In: Waser, PG (ed) Cholinergic mechanisms. Raven Press, New York, 501–529
Kolb, B and Whishaw, IQ (1989) Plasticity in the neocortex: mechanisms underlying recovery from early brain damage. Prog. Neurobiol. 32, 235–276
Kuhar, MJ, Birdsall, NJM, Burgen, ASV and Hulme, EC (1980) Ontogeny of muscarinic receptors in rat brain, Brain Res. 184, 375–383
Nordberg, A, Zang, X, Fredriksson, A and Eriksson, P (1991) Neonatal nicotine exposure induces permanent changes in brain nicotinic receptors and behaviour in adult mice. Dev. Brain Res. 63, 201–207
Slotkin, TA, Orband-Miller, L and Queen, KL (1987) Development of [3H]nicotine binding sites in brain, J. Pharmacol. Exp. Ther. 233, 361
Tilson, HA and Harry, GJ (1994) Developmental neurotoxicology of poly chlorinated biphenyls and related compounds. In: Isaacson, RL and Jensen, KF (eds), The vulnerable brain and environmental risks., Plenum Press, New York, vol. 3, 267–279
Vijverberg, HPM and van den Bercken, J (1990) Neurotoxicological effects and the mode of action of pyrethroid insecticides. Crit. Rev. Toxicol. 21, 105–126
Woolley, DE (1982) Neurotoxicity of DDT and possible mechanism of action. In: Prasad, KN and Vernadakis, A (eds) Mechanism of Actions of Neurotoxic substances., Raven Press, New York, 95–141
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Eriksson, P. (1996). Developmental Neurotoxicology in the Neonate - Effects of Pesticides and Polychlorinated Organic Substances. In: Seiler, J.P., Kroftová, O., Eybl, V. (eds) Toxicology - From Cells to Man. Archives of Toxicology, vol 18. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61105-6_9
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DOI: https://doi.org/10.1007/978-3-642-61105-6_9
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