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Antisense RNA

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Post-transcriptional Control of Gene Expression

Part of the book series: NATO ASI Series ((ASIH,volume 97))

Abstract

Antisense RNAs are small, diffucible transcripts that are complementary to specific target RNAs. When the antisense and target RNAs pair to one another, target RNA function is altered or inhibited. Natural antisense RNA systems are abundant in prokaryotes and their existence in eukaryotes has been claimed. Artificially engineered antisense RNAs are often used to control gene expression in eukaryotes, especially where classical genetic approaches are difficult or unavailable. Natural and artificial antisense RNA control has been reviewed extensively (Simons and Kleckner, 1988; Simons, 1991; Mol and van der Krol, 1991; Eguchi et al., 1991; Erickson and Izant, 1992; Simons, 1993),

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Author information

Authors and Affiliations

  1. Department of Microbiology, Biomedical Center, Uppsala University, Box 581, S-751 23, Uppsala, Sweden

    Kurt Nordström

  2. Department of Genetics, Stanford University School of Medicine, Stanford, CA, 94305-5120, USA

    Stanley N. Cohen

  3. Department of Microbiology and Molecular Genetics, University of California Los Angeles, 5304 Life Sciences Building, CA, 90024-1489, USA

    Robert W. Simons

Authors
  1. Kurt Nordström
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  2. Stanley N. Cohen
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  3. Robert W. Simons
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Editor information

Editors and Affiliations

  1. Biological Laboratories, Harvard University, 16 Divinity Avenue, 02138, Cambridge, MA, USA

    Orna Resnekov

  2. Department of Microbiology and Genetics, Vienna Biocenter, Dr. Bhor-Gasse 9, A-1030, Vienna, Austria

    Alexander von Gabain

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© 1996 Springer-Verlag Berlin Heidelberg

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Nordström, K., Cohen, S.N., Simons, R.W. (1996). Antisense RNA. In: Resnekov, O., von Gabain, A. (eds) Post-transcriptional Control of Gene Expression. NATO ASI Series, vol 97. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60929-9_20

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  • DOI: https://doi.org/10.1007/978-3-642-60929-9_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64609-6

  • Online ISBN: 978-3-642-60929-9

  • eBook Packages: Springer Book Archive

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