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Cellular Actions of Antiepileptic Drugs

  • Chapter
Antiepileptic Drugs

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 138))

Abstract

Antiepileptic drugs have been the mainstays of the treatment of patients with epilepsy. From 1978 to 1993 the primarily used antiepileptic drugs have been Phenytoin, carbamazepine, barbiturates and primidone, benzodiazepines, valproic acid and ethosuximide. Recently a number of new antiepileptic drugs have been developed which include gabapentin, lamotrigine, oxcarbazepine, vigabatrin, tiagabine, topiramate and felbamate. Unfortunately, early experience with felbamate was associated with an unacceptably high incidence of aplastic anaemia (Pennell et al. 1995) and chemical hepatitis, and in August of 1994 the manufacturer and the United States Federal Drug Administration recommended that, if clinically possible, patients be withdrawn from felbamate. Fortunately, the remaining newly developed antiepileptic drugs have been approved in many countries and are currently in use.

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  1. R. L. Macdonald
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  1. Departments of Medicine, Royal Brisbane Hospital, University of Queensland, Clinical Sciences Building, Herston, Qld., 4029, Australia

    Mervyn J. Eadie AO, MD, PhD

  2. Australian Centre for Clinical Neuropharmacology, St. Vincent’s Hospital, Fitzroy, Victoria, 3065, Australia

    Frank J. E. Vajda M.D.

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Macdonald, R.L. (1999). Cellular Actions of Antiepileptic Drugs. In: Eadie, M.J., Vajda, F.J.E. (eds) Antiepileptic Drugs. Handbook of Experimental Pharmacology, vol 138. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60072-2_5

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