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Strategies for Administering Neurotrophic Factors to the Central Nervous System

  • Chapter
Neurotrophic Factors

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 134))

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Abstract

The study of neurotrophic factors (NFs) has become one of the most rapidly evolving and expanding fields in the contemporary neurosciences. NFs are growth factors that enhance the survival, maintenance, differentiation and repair of neural cells (Levi-Montalcini 1987). NFs also increase neurite out-growth and neurotransmitter production. The neurons derive neurotrophic support either by means of retrograde transport from the “target cells” they innervate or from anterograde trophic support of presynaptic terminals. Glial cells, like Schwann cells, astrocytes and oligodendrocytes do provide NFs as well.

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Abbreviations

6-OHDA:

6-hydroxydopamine

AAV:

adeno-associated virus

Ad:

adenoviral

ALS:

amyotrophic lateral sclerosis

BBB:

blood—brain barrier

BHK:

baby hamster kidney

CNS:

central nervous system

CNTF:

ciliary neurotrophic factor

GDNF:

glial cell-derived neurotrophic factor

IGF-1:

insulin-like growth factor-1

NF:

neurotrophic factor

NGF:

nerve growth factor

PD:

Parkinson’s disease

PNS:

peripheral nervous system

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Authors
  1. A. F. Hottinger
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  2. P. Aebischer
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Editors and Affiliations

  1. Merck Sharp & Dohme, Neuroscience Research Centre, Terlings Park, CM20 2QR, Harlow, Essex, UK

    Franz Hefti Ph.D.

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Hottinger, A.F., Aebischer, P. (1999). Strategies for Administering Neurotrophic Factors to the Central Nervous System. In: Hefti, F. (eds) Neurotrophic Factors. Handbook of Experimental Pharmacology, vol 134. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59920-0_10

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