Skip to main content
SpringerLink
Log in

Diagnostik und Therapie des okkulten Primärtumors mit Lymphknotenmetastasen im Kopf-, Halsbereich

  • Chapter
Kompendium der praktischen Medizin

Zusammenfassung

Etwa 3–5% der malignen Neuerkrankungen im Hals-Nasen-Ohrenbereich sind Halslymphknotenmetastasen eines unbekannten Primärtumors [12, 54]. Damit sind die Lymphknotenketten des Halses ein häufiger Manifestationsort eines „carcinoma of unknown primary“, eines sog. CUP-Syndroms.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Abbruzzese JL, Abbruzzese MC, Hess KR, et al. (1994) Unknown primarycarcinoma: natural history and prognostic factors in 657 consecutive patients. J Clin Oncol 12:1272–1280

    PubMed  CAS  Google Scholar 

  2. Abbruzzese JL, Raber MN, Frost P (1988) An effective strategy for the evaluation of unknown primary tumors. Cancer Bull 41:157–161

    Google Scholar 

  3. Abbruzzese JL, Abbruzzese-MC, Lenz-R, Hess-KR, Raber-MN (1995) Analysis of a diagnostic strategy for patients with suspected tumors of unknown origin. J Clin Oncol 13:2094–2103

    PubMed  CAS  Google Scholar 

  4. Abrams HL, Spiro R, Goldstein N (1950) Metastases in carcinoma. Analysis of 1000 autopsied cases. Cancer 3:74–85

    Article  PubMed  CAS  Google Scholar 

  5. Altman E, Cadman E (1986) An analysis of 1539 patients with cancer of unknown primary site. Cancer 57:120–124

    Article  PubMed  CAS  Google Scholar 

  6. Altmannsberger M,Droese M,Osbom M,Weber K(1984) Immunzytologische Klassifizierung von Metastasen bei unbekanntem Primärtumor. Pathologe 5:269–274

    PubMed  CAS  Google Scholar 

  7. Bauet JW,Abemayor E Jabour BA, Hawkins RA, Ho C,Ward PH (1992) Positron emission tomography: a new, precise imaging modality for detection of primary head and neck tumors and assessment of cervical adenopathy. Laryngoscope 102:281–288

    Google Scholar 

  8. Bataini JP, Roriguez J, Jaulery C, Brugere J, Ghossein NA (1987) Treatment of metastatic neck nodes secondary to an occult epidermoid carcinoma of the head and neck. Laryngoskope 97:1080–1084

    CAS  Google Scholar 

  9. Bossman FT, Giard RWM, Kruseman ACN, et al. (1980) Human chorionic gonadotropin and alpha-feto-protein in testicular germ cell tumours: a retrospective immunohistochemical study. Histopatho-logy 4:673–684

    Google Scholar 

  10. Brewin T (1981) The cancer patient — too many scans and X-rays? Lancet 1:1098–1099

    Article  Google Scholar 

  11. Carter RL, Bliss JM, Soo KC, O’Brien CJ (1987) Radical neck dissection for squamous carcinomas, pathological findings and their clinical implications with particular reference to transcapsular spread. Int J Radiat Biol Oncol Phys 13:825–832

    Article  CAS  Google Scholar 

  12. Coker DD,Casterline PF, Chambers RG, Jaques DA (1977) Metastases to the lymph nodes of the head and neck from an unknown primary site. Am J Surg 134:517–522

    Article  PubMed  CAS  Google Scholar 

  13. Comess MS, Beahrs OH, Dockerty MB (1957) Cervical Metastasis from occult carcinoma. Surg Gynecol Obstet 104:607–617

    PubMed  CAS  Google Scholar 

  14. Compagno J,Hyams VJ,Safavian M (1976) Does branchiogenic carcinoma really exist? Arch Pathol Lab Med 100:311–314

    Google Scholar 

  15. Daugaard D (1994) Unknown primary tumours. Cancer Treatment Reviews 20:119–147

    Article  PubMed  CAS  Google Scholar 

  16. Davidson BJ, Spiro RH, Patel S, Shah JP (1994) Cervical metastases of occult origin: the impact of combined modality therapy. Am J Surg 168:395

    Article  PubMed  CAS  Google Scholar 

  17. de Braud F, Heilbrun K, Ahmed K, et al. (1989) Metastatic squamous cell carcinoma of an unknown primary localised to the neck. Advantages of an aggressive treatment. Cancer 64:510–515

    Article  PubMed  Google Scholar 

  18. de Campos ES, Menasce LP, Radford J, Harris MJ, hatcher N (1994) Metastatic carcinoma of uncertain primary site: a retrospective review of 57 patients treated with vincristine, doxorubicin, cyclophosphamide (VAC) or VAC alternating with cisplatin and etoposide (VAC/PE). Cancer 73:470–475

    Article  PubMed  Google Scholar 

  19. Delank KW, Freytag G, Stoll W (1992) Klinische Relevanz der malignen lateralen Halszysten. Laryn-gorhinootologie 71:611 –617

    Google Scholar 

  20. Didolkar MS, Fanous N, Elias EG, Moore RH (1977) Metastatic carcinomas from occult primary tumors. A study of 254 patients. Ann Surg 186:625

    Article  PubMed  CAS  Google Scholar 

  21. Dohnert-G (1971) Lymphoepithelioma Schmincke-Regaud. Virchows Arch Pathol Anat Physiol Klin Med 352:279–284

    PubMed  CAS  Google Scholar 

  22. Duda RB, Zimmer AM, Rosen ST (1990) Radioimmune localization of occult carcinoma. Arch Surg 125:866–870

    PubMed  CAS  Google Scholar 

  23. Dunst J, Sauer R, Weidenbecker M (1988) Halslymphknotenmetastasen bei unbekanntem Primärtumor. Strahlenther Onkol 164:129–135

    PubMed  CAS  Google Scholar 

  24. Fitzpatrick PJ, Kotalik JF (1974) Cervical metastases from an unknown primary tumor. Radiology 110:659–663

    PubMed  CAS  Google Scholar 

  25. Fletcher JA, Kozakewich TP, Hoffer FA (1991) Diagnostic relevance of clonal cytogenetic aberrations in malignant soft tissue tumors. N Engl J Med 324:436–441

    Article  PubMed  CAS  Google Scholar 

  26. France CJ, Lucas R (1963) The management and prognosis of metastatic neoplasms of the neck with an unknown primary. Am J Surg 106:835

    Article  PubMed  CAS  Google Scholar 

  27. Frost P (1991) Unknown primary tumors: an example of accelerated (type 2) tumor progression. In: Sudilovski, O., Ed. Boundaries between promotion and progression during carcinogenesis. New York, Plenum Press, pp 233–241

    Google Scholar 

  28. Gaber AO, Rice P, Eaton C, Pietrafitta JJ, Spatz E, Deckers PJ (1983) Metastatic malignant disease of unknown origin. Am J Surg 145:493–497

    Article  PubMed  CAS  Google Scholar 

  29. Gatter KC (1992) Morphology of Neoplasms. In: McGee JO, Isaacson PG, Wright NA (eds) Oxford Textbook of Pathology, vol. 1. New York, Oxford University Press, pp 577–585

    Google Scholar 

  30. Gluckman JL, Robbins KT, Fried MP (1990) Cervical metastatic squamous carcinoma of unknown or occult primary source. Head Neck 12:440–443

    Article  PubMed  CAS  Google Scholar 

  31. Glynne Jones RGT, Anand A, Young TE, Berry RJ (1990) Metastatic carcinoma in the cervical lymph nodes from an occult primary: a conservative approach to the role of radiotherapy. Int J Radiat Oncol 18:289–294

    Article  CAS  Google Scholar 

  32. Gorich J, Beyer-Enke SA, Muller M, et al. (1988) Die Wertigkeit der Computertomographie bei der Suche nach unbekanntem Primärtumor. RÖFO-Fortschr Geb Röntgenstr Nuklearmed 149:277–279

    Article  PubMed  CAS  Google Scholar 

  33. Grignon-DJ, Hammond-EH (1995) College of American Pathologists Conference XXVI on clinical relevance of prognostic markers in solid tumors. Report of the Prostate Cancer Working Group. Arch Pathol Lab Med 119:1122–1126

    PubMed  CAS  Google Scholar 

  34. Hainsworth JD, Einhorn LH,Williams SD, Stewart M,Greco FA (1982) Advanced gonadal germ cell tumors: successfull treatment with combination chemotherapy. Proc Am Soc Clin Oncol 1:C-413

    Google Scholar 

  35. Hainsworth JD, Greco A (1983) Testicular germ cell neoplasms. Am J Med 75:817–832

    Article  PubMed  CAS  Google Scholar 

  36. Hainsworth JD, Wright EP, Johnson DH, Davis BW, Greco FA (1991) Poorly differentiated carcinoma of unknown primary site: clinical usefulness of immunoperoxidase staining. J Clin Oncol 9:1931–1938

    PubMed  CAS  Google Scholar 

  37. Hamilton CS, Langlands AO (1987) Adenocarcinoma of unknown primary site: a clinical and cost benefit analysis. Int J Radiat Oncol Biol Phys 13:1497–1503

    Article  PubMed  CAS  Google Scholar 

  38. Heinritz H, Marienhagen J, Wolf F, et al. (1992) Szintigraphische Darstellung von Kopf-Hals-Karzinomen mit 99m Technetium (v) Dimercaptosuccinic acid. Eine prospektive klinische Studie. HNO 40:437–441

    CAS  Google Scholar 

  39. Jaspersen D (1992) Das CUP-Syndrom-Malignomerkrankung bei unbekanntem Primärtumor. Folge 1: Diagnostisches Prozedere. Fortschr Med 110:519–520

    PubMed  CAS  Google Scholar 

  40. Jesse RH, Neff LE (1966) Metastatic carcinoma in cervical nodes with an unknown primary lesion. Am J Surg 112:547–553

    Article  PubMed  CAS  Google Scholar 

  41. Johnson JT, Barnes EL, Myers EN, et al. (1981) The extracapsular spread of tumors in cervical node metastasis. Arch Otolaryngol 107:725–729

    PubMed  CAS  Google Scholar 

  42. Jones AS, Phillips DE, Cook JA, Field JK, Gati I (1993) Non-squamous malignancy inlymph nodes: the occult primary. Clin Otolaryngol 18:311–316

    Article  PubMed  CAS  Google Scholar 

  43. Jose B, Bosch A, Caldwell WL, Frias Z (1979) Metastases to neck from unknown primary tumor. Acta Radiol Oncol 18:161–170

    Article  CAS  Google Scholar 

  44. Jungehiilsing RM, Scheidhauer K (1994) FDG-PET im Vergleich mit CT, MRT, und Sonographie zum Staging von Kopf-,Hals-Plattenepithelkarzinomen. Eur Arch Otol Rhinol Laryngol Suppl 11:171–172

    Google Scholar 

  45. Jungehiilsing M, Scheidhauer K, Damm M, Schneider D (995) 18-FDG-PET bei Patienten mit Tumoren unbekannter Primärlokalisation. Mitteilungen der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Halschirurgie, 20/1, Nr. 324

    Google Scholar 

  46. Kambhu SA, Kelsen DP, Fiore J, et al. (1990) Metastatic adenocarcinomas of unknown primary site. Am J Clin Oncol 13:55–60

    Article  PubMed  CAS  Google Scholar 

  47. Kirsten F, Chi C, Leeary JA, et al. (1987) Metastatic adeno or undifferenciated carcinoma from an unknwon primary site — natural history and guidelines for identification on treatable subsets. Quart J Med 62:143

    PubMed  CAS  Google Scholar 

  48. Klee GG, Go VLW (1982) Laboratory report. Serum tumor markers. Mayo Clin Proc 57:129–132

    PubMed  CAS  Google Scholar 

  49. Knobber D, Lobeck H, Steinkamp HJ (1995) Gibt es die malignisierte laterale Halszyste doch? HNO 43:104–10

    PubMed  CAS  Google Scholar 

  50. Knothe J, Fritsche F (1980) Zur Halslymphknotenmetastasierung bei unbekanntem Primärtumor. Laryngol Rhinol Otol 59:221–226

    Article  CAS  Google Scholar 

  51. Krementz ET, Cerise EJ, Foster DS, Morgan LR (1979) Metastases of undetermined source. Curr Probl Cancer 4:4–37

    Article  PubMed  CAS  Google Scholar 

  52. Kruger R,de Leon F, Maihoff J (1992) Der Wert der Immunhistochemie in der histologischen Routinediagnostik von Metastasen unbekannter Primärtumoren. Pathologe 13:65–72

    PubMed  CAS  Google Scholar 

  53. Kurtin PJ, Pinkus GS (1985) Leukocyte common antigen — a diagnostic discriminant between hematopoietic and nonhematopoietic neoplasms in paraffin sections using monoclonal antibodies. Hum Pathol 16:353–365

    Article  PubMed  CAS  Google Scholar 

  54. Lefebvre JL,Coche-Dequeant B,Ton Van J,Buisset E,Adenis A (1990) Cervical lymph nodes from an unknown primary tumor in 190 patients. Am J Surg 160:443–446

    Article  PubMed  CAS  Google Scholar 

  55. Leipzig B,Winter ML, Hokanson JA (1981) Cervical nodal metastases of unknown origin. Laryngoscope 91:593–598

    Article  PubMed  CAS  Google Scholar 

  56. Leonard RJ, Nystrom JS (1993) Diagnostic evaluation of patients with carcinoma of unknown primary tumor site. Sem Oncol 20:244–250

    CAS  Google Scholar 

  57. Levine PH, Connelly RR (1985) Epidemiology of nasopharyngeal cancer. In: Wiites RE (Ed) Head and Neck Cancer. Wiley, Chichester, Ss. 13–36

    Google Scholar 

  58. Lote K (1989) Metastatic cancer from unknown primary site. In: Veronesi U, Arnesjo B, Burn I, Denis L, Mazzeo F (eds) Surgical Oncology. A European Handbook. Springer, Berlin Heidelberg New York, pp 976–983

    Google Scholar 

  59. Mackay B, Ordonez NG (1986) The role of the pathologist in the evaluation of poorly differentiated tumors and metastatic tumors of unknown origin. In: Fer MF, Greco FA, Oldham RK (Eds) Poorly Differentiated Neoplasms and Tumors of Unknown Origin. Grüne & Stratton,Orlando FL, pp 3–73

    Google Scholar 

  60. Marcial-Vega VA, Cardenes H, Perez CA, Devineni VR, Simpson JR, Fredrickson JM, Sessions DG, Spector GG, Thawley-SE (1990) Cervical metastases from unknown primaries, radiotherapeutic management and appearance of subsequent primaries. Int J Radiât Oncol Biol Phys 19:919–928

    Article  PubMed  CAS  Google Scholar 

  61. Maulard C, Housset M, Brunei P, Huart J, Ucla L, Rozec C, Delanian S, Baillet F (1992) Postoperative rediation therapy for cervical lymph node metastases from an occult squamous cell carcinoma. Laryngoscope 102:184

    Article  Google Scholar 

  62. McCunnif A, Raben M (1986) Metastatic carcinoma of the neck from an unknown primary. Int J Radiat Oncol Biol Phys 12:1849–1852

    Article  Google Scholar 

  63. McMillan JH, Levine E, Stephens RH (1982) Computed tomography in the evaluation of metastatic adenocarcinoma from an unknown primary site. Radiology 143:143–146

    PubMed  CAS  Google Scholar 

  64. Medina JE (1989) A rational classification of neck dissections. Otolaryngol Head Neck Surg 100:169–76

    PubMed  CAS  Google Scholar 

  65. Moertel CG, Reitermeier RJ, Schutt AJ, Hahn RG (1972) Treatment of the patient with adenocarcinoma of unknown origin. Cancer 30:1469–1472

    Article  PubMed  CAS  Google Scholar 

  66. Mohit-Tabatabai MA, Dasmahapatra KS, Rush BF, Ohanian M (1986) Management of squamous cell carcinoma of unknown origin in cervical lymph nodes. Am J Surg 52:152–154

    CAS  Google Scholar 

  67. Motzer RJ, Rodriguez E, Reuter VE, Bosl GJ, Mazumdar M, Chaganti RS (1995) Molecular and cytogenetic studies in the diagnosis of patients with poorly differentiated carcinomas of unknown primary site. J Clin Oncol 13:274–282

    PubMed  CAS  Google Scholar 

  68. Muir C (1995) Cancer of unknown primary site. Cancer 75:353–356

    Article  PubMed  CAS  Google Scholar 

  69. Neel HB, Pearson GR, Weiland LH,Taylor WF,Goepfert HH (1981) Immunologic detection of occult primary cancer of the head and neck. Otolaryngol Head Neck Surg 89:230–234

    PubMed  Google Scholar 

  70. Neilan BA (1983) Adenocarcinoma of unknown origin. CA 33:237–241

    PubMed  CAS  Google Scholar 

  71. Nissenblatt MR (1981) The CUP syndrome (Carcinoma of unknown primary). Cancer Treat Rev 8:211–224

    Article  PubMed  CAS  Google Scholar 

  72. Nordstrom DGJefik HH, Latourette HB (1979) Cervical lymph node metastases from an unknown primary. Int J Radiat Oncol Biol Phys 5:73–76

    PubMed  CAS  Google Scholar 

  73. Nystrom SJ, Weiner JM, Wolf RM, Bateman JR, Viola MV (1979) Identifying the primary site in metastatic cancer of unknown origin. Inadequacy of roentgenographic procedures. JAMA 241:381–383

    Article  PubMed  CAS  Google Scholar 

  74. Osteen RT, Kopf G, Wilson RE (1978) In pursuit of the unknown primary. Am J Surg 135:494–498

    Article  PubMed  CAS  Google Scholar 

  75. Panza N, Lombardi G, Rosa M, Pacilio G, Lapenta L, Salvatore M (1987) High serum thyroglobulin levels, diagnostic indicators inpatients from unknown primary sites. Cancer 60:2233–2236

    Article  PubMed  CAS  Google Scholar 

  76. Pearson GR,Weiland LH, Neel HB,Taylor W, Early J, Mulroney SE, Goepfert H, Lanier AJalvot ML, Pilch B, Goodman M, Huang A, Levine PH, Hyans V, Moran E, Henle G, Henle W (1983) Application of Epstein-Barr virus serology to the diagnosis of North American nasopharyngeal carcinoma. Cancer 51:260–268

    Article  PubMed  CAS  Google Scholar 

  77. Pinkus GS, Kurtin PJ (1985) Epethelial membrane antigen — a diagnostic discriminant in surgical pathology: Immunohistochemical profile in epithelial, mesenchymal, and hematopoietic neoplasms using paraffin sections and monoclonal antibodies. Hum Pathol 16:929–940

    Article  PubMed  CAS  Google Scholar 

  78. Scanion EF (1985) The process of metastasis. Cancer 55:1163–1166

    Article  Google Scholar 

  79. Schabel FM (1975) Concepts for systemic treatment of micrometastases. Cancer 35:15–24

    Article  PubMed  CAS  Google Scholar 

  80. Schapira DV Jarrett AR (1995) The need to consider survival, outcome, and expense when evaluating and treating patients with unknown primary carcinoma. Arch Intern Med 155:2050–2054

    Article  PubMed  CAS  Google Scholar 

  81. Schicha H (1990) Kompendium der Nuklearmedizin. Schattauer, Stuttgart New York

    Google Scholar 

  82. Schipper JH, Schrader M, Arweiler D, Müller S, Sciuk J (1996) Die Positronenemissionstomographie zur Primärtumorsuche bei Halslymphknotenmetastasen mit unbekanntem Primärtumor. HNO 44:254–257

    PubMed  CAS  Google Scholar 

  83. Schultz-Coulon-HJ, Peter-H H (1984) Melanommetastasen im Halsbereich bei unbekanntem Primärtumor. Laryngol-Rhinol-Otol 63:17–20

    Article  CAS  Google Scholar 

  84. Smith PE, Krementz ET, Chapman W (1967) Metastatic cancer without a detectable primary site. Am J Surg 113:633–637

    Article  PubMed  CAS  Google Scholar 

  85. Snee MP, Vyramuthu N (1985) Metastatic carcinoma from unknown primary site: the experience of a large oncology centre. Br J Radiol 58:1091–1095

    Article  PubMed  CAS  Google Scholar 

  86. Spiessl B, Hermanek O, Scheibe G, Wagner R (1985) TNM-Atlas. Illustrierter Leitfaden zur TNM/pTNM-Klassifikation maligner Tumoren. Springer, Berlin Heidelberg New York

    Google Scholar 

  87. Spiro RH, De Rose G, Strong EW (1983) Cervical node metastases of occult origin. Am J Surg 146:441–446

    Article  PubMed  CAS  Google Scholar 

  88. Steinkamp-HJ, Knobber-D, Zwicker-C, Felix-R (1993) Halslymphknotenmetastasen bei unbekanntem Primärtumor: Gibt es eine bildgebende Differentialdiagnostik? Laryngorhinootologie 72:78–85

    Article  PubMed  CAS  Google Scholar 

  89. Stewart JF Jattersall MNH, Woods RL,Fox RM (1979) Unknown primary adenocarcinoma: incidence of overinvestigation and natural history. Br Med J 1:1530–1533

    Article  PubMed  CAS  Google Scholar 

  90. Strasnick B, Moore DM, Abemayer E, Juillard G, Fu YS (1990) Occult primary tumors.The management of isolated submandibular lymph node metastases. Arch Otolaryngol Head Neck Surg 116:173–176

    PubMed  CAS  Google Scholar 

  91. Subramanian R,Chilla R (1995) Halslymphknotenmetastasen bei unbekanntem Primärtumor. Verlaufsbeobachtung an 58 Patienten. HNO 43:299–303

    PubMed  CAS  Google Scholar 

  92. Sugarbaker EV (1980) Patterns of metastasis in human malignancies. In: Marchalonis JJ, Hanna MG, Fidler IJ (Ed.) Cancer Biology reviews, Vol. 2. Dekker, New York

    Google Scholar 

  93. Talmadge JE, Fidler IJ (1982) Enhanced metastatic potential of tumor cells harvested from spontaneous metastases of heterogeneous murine tumors. JNCI 69:975–980

    PubMed  CAS  Google Scholar 

  94. Van den Brekel MPM, Catelijns JA, Steel H, Golden RP, Meyer, Snow G (1993) Modern imaging techniques and ultrasound — guided aspiration cytology for the assessment of neck node metastasis. A prospective comparative study. Eur Arch Otorhinolaryngol 250:11–17

    Article  PubMed  Google Scholar 

  95. van der Gaast A, Verweij J, Planting AS, Hop WD, Stoter G (1995) Simple prognostic model to predict survival in patients with undifferntiated carcinoma of unknown primary site. J Clin Oncol 13:1720–1725

    PubMed  Google Scholar 

  96. Vannetzel JM, Dray M, Murthy AK (1990) Proc Am Soc Clin Oncol 9:660

    Google Scholar 

  97. Vikram B (1980) Changing patterns of failure in advanced head and neck cancer. Arch Otolaryngol 110:564–565

    Google Scholar 

  98. Vikram G, Strong EW, Shah JP, Spiro R (1984) Failure at the primary site following multimodality treatment in advanced head and neck cancer. Head Neck Surg 6:720–723

    Article  PubMed  CAS  Google Scholar 

  99. Volkmann von R (1882) Das tiefe branchiogene Halskarzinom. Zentralbl Chir 9:49–51

    Google Scholar 

  100. von-Heyden-HW, Hansen-D, Kaboth U, Nagel-GA, Hoffmann-H, Schneider-B (1984) Metastasierendes Adenokarzinom bei unbekanntem Primärtumor. Dtsch Med Wochenschr 109:15–19

    Article  Google Scholar 

  101. Wang RC, Goepfert H, Barber AE, Wolf P (1990) Unknown primary squamous cell carcinoma metastatic to the neck. Arch Otolaryngol Head Neck Surg 116:1388–1393

    PubMed  CAS  Google Scholar 

  102. Weir L, Keane T,Cummings B,Goodman R,O’Sullivan B, Payne D,Warde P (1995) Radiation treatment of cervical lymph node metastases from an unknown primary: an analysis of outcome by treatment volume and other prognostic factors. Radiother Oncol 35:206–211

    Article  PubMed  CAS  Google Scholar 

  103. Weiss L, Hadock K, Pickren JW, Lane WW (1980) Organ vascularity and metastatic frequency. Am J Pathol 101:101–114

    PubMed  CAS  Google Scholar 

  104. Wilson CBJH (1992) Pet scanning in oncology. Eur J Cancer 28:508–510

    Article  PubMed  CAS  Google Scholar 

  105. Woods RL, Fox RM Jattersall MHN, Levo JA, Brodie GN (1980) Metastatic adenocarcinomas of unknown primary site. N Eng J Med 303:87–89

    Article  CAS  Google Scholar 

  106. Yam LT (1974) Clinical significance of the human acid phosphatases. Am J Med 56:604–615

    Article  PubMed  CAS  Google Scholar 

  107. Yang ZY, Hu YH, Yan JH, Cai WM, Qin DX, Xu GZ, Wu XL (1983) Lymph node metastases in the neck from an unknown primary report on 113 patients. Acta Radiol Oncol 22:17–22

    Article  PubMed  CAS  Google Scholar 

  108. zur Hausen H, Schulte-Holthausen H, Klein G (1970) EBV DNA in biopsies of Burkitt tumors and anaplastic carcinomas of the nasopharynx. Nature 228:1056–1058

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde der Universität zu Köln, Joseph-Steltzmann-Straß 9, D-50924, Köln, Deutschland

    Dr. M. Jungehülsing & H. E. Eckel

  2. Klinik und Poliklinik für Strahlentherapie der Universität zu Köln, Deutschland

    S. Staar

  3. Hals-,Nasen-,Ohrenklinik des Lukaskrankenhauses Neuss, Deutschland

    O. Ebeling

Authors
  1. Dr. M. Jungehülsing
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. E. Eckel
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. Staar
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. O. Ebeling
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Arzt für Allgemeinmedizin, Arbeitsmedizin, Geburtshelfer, Prunkgasse 9, 55126, Mainz, Deutschland

    Benno König

  2. Kinderklinik der Universität München, Lindwurmstraße 4, 80337, München, Deutschland

    Dietrich Reinhardt

  3. Medizinische Klinik I Städtisches Krankenhaus Hildesheim, Lehrkrankenhaus der Medizinischen Hochschule Hannover, Weinberg 1, 31134, Hildesheim, Deutschland

    Hans-Peter Schuster

Rights and permissions

Reprints and permissions

Copyright information

© 2000 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Jungehülsing, M., Eckel, H.E., Staar, S., Ebeling, O. (2000). Diagnostik und Therapie des okkulten Primärtumors mit Lymphknotenmetastasen im Kopf-, Halsbereich. In: König, B., Reinhardt, D., Schuster, HP. (eds) Kompendium der praktischen Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59754-1_72

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-59754-1_72

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64110-7

  • Online ISBN: 978-3-642-59754-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation