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Clinicopathological Differential Diagnosis of Drug-Induced Toxic Epidermal Necrolysis (Lyell’s Syndrome) and Acute Graft-Versus-Host Reaction

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Dermatopathology

Part of the book series: Current Topics in Pathology ((CT PATHOLOGY,volume 94))

Abstract

Over the past decades, allogeneic bone marrow transplantation (BMT), also called allogeneic haematopoietic stem cell transplantation (HSCT), has been progressively refined. It evolved from last-resort experiments to first-line therapy for various haematolymphoid malignancies and a few other metabolic disorders. Despite effective immunosuppressive regimens, allogeneic graft-versus-host disease (GVHD) remains a serious and common complication of BMT; mortality increases with GVHD severity [1]. GVHD has also been documented following transplantation of solid organs containing passenger leukocytes. This latter situation is notable for its rarity and its association with high mortality [2]. Contrasting with its deleterious effects, GVHD exhibits an antitumoral effect termed the graf-tversus-leukaemia effect. Such a beneficial aspect has also been reported in multiple myeloma and breast cancer.

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  1. P. Paquet
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  2. J. E. Arrese
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  3. Y. Beguin
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  4. G. E. Piérard
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Editors and Affiliations

  1. Department of Morbid Anatomy and Histopathology, The Royal London Hospital, Whitechapel, London, E1 1BB, Great Britain

    R. Cerio

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Paquet, P., Arrese, J.E., Beguin, Y., Piérard, G.E. (2001). Clinicopathological Differential Diagnosis of Drug-Induced Toxic Epidermal Necrolysis (Lyell’s Syndrome) and Acute Graft-Versus-Host Reaction. In: Cerio, R. (eds) Dermatopathology. Current Topics in Pathology, vol 94. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59552-3_3

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  • DOI: https://doi.org/10.1007/978-3-642-59552-3_3

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