Abstract
Tumour growth and development depend on a complex cascade of angiogenic factors. The aim of the study is evaluation of the level of growth factors VEGF and bFGF, and adhesion molecules sICAM-1, s VCAM-1 in the serum of patients with papillary thyroid cancer. The study comprised 35 patients aged 21–68 years (mean age 46±14) who had papillary thyroid cancer diagnosed on the basis of thin needle aspiration biopsy, and were qualified for operative treatment. This group comprised 28 women and seven men. The control group was 26 healthy individuals. Serum concentrations of bFGF, VEGF, slCAM-1, and sVCAM-1 were evaluated by the enzyme-linked immunosorbent assay (ELISA) method. We have observed significantly higher mean concentrations of bFGF, VEGF, and sICAM-1 in the serum of patients with thyroid cancer compared with the control group. There was no significant difference between the sVCAM-1 concentrations of the thyroid cancer group and the control group.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Fidler IJ, Ellis LM (1994) The implications of angiogenesis to the biology and therapy of cancer metastasis. Cell 79:185–188
Ferrara N, Henzel WJ (1989) Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun 161:851–859
Ploüet J, Schilling J, Gospodarowicz D (1989) Isolation and characterization of a newly identified endothelial cell mitogen produced by at T20 cells. EMBO J 8:3801–3807
Brown LF, Berse B, Jackman RW, Tognazzi K, Mansean EJ, Dvorak HF, Senger DR (1993) Increased expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in kidney and bladder carcinoma. Am J Pathol 143:1255–1262
Brown LF, Berse B, Jackman RW, Tognazzi K, Mansean EJ, Senger DR, Dvorak HF (1993) Expression of vascular permeability factor (vascular endothelial growth factor) and its receptor in adenocarcinomas of the gastrointestinal tract. Cancer Res 53:4727–4735
Shweioki D, Itin A, Soffer D, Keshet E (1992) Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359:843–845
Basilico C, Moscatelli D (1992) The FGF family of growth factors and oncogenes. Adv Cancer Res 59:115–1
Moscatelli D, Presta M, Joseph-Silverstein J, Rifkin DB (1986) Both normal and tumor cells produce basic fibroblast growth factor. J Cell Physiol 129:273–276
Edelman GM (1993) A golden age for adhesion. Cell Adhes Comm 1:1–7
Springer TA (1990) Adhesion receptors of the immune system. Nature 346:425–434
McCormick BA, Zetter BR (1992) Adhesive interactions in angiogenesis and metastasis. Pharmacol Ther 53:239–260
Kawai K, Resetkova E, Enomoto T, Fornasier V, Volpe R (1998) Is human leukocyte antigen-DR and intercellular adhesion molecule-1 expression on human thyreocytes constitu-tive in papillary thyroid cancer? Comparative studies of human thyroid xenografts in severe combined immunodeficient and nude mice. J Clin Endocrinol Metab 83:157–164
Garofalo A, Chirivi RG, Foglieni C, Pigott R, Mortarini R, Martin-Padura I, Anichini A, Gearing AJ, Sanchez-Madrid F, Dejana E (1995) Involvement of very late antigen 4 integrin on melanoma in interleukin 1-augmented experimental metastasis. Cancer Res 55:414–419
Fogler WE, Volker K, McCormick KL, Watanabe M, Ortaldo JR, Wiltrrout RH (1996) NK cell infiltration into lung, liver, and subcutaneous B16 melanoma is mediated by VCAM-l/VLA-4 interaction. J Immunol 156:4707–4714
Feldman AL, Pak H, Yang JC, Alexander HR, Libutti SK (2001) Serum endostatin levels are elevated in patients with soft tissue sarcoma. Cancer 15:1525–1529
Ueno K, Inoue Y, Kawaguchi T, Hosoe S, Kawahara M (2001) Increased serum levels of basic fibroblast growth factor in lung cancer patients: relevance to response of therapy and prognosis. Lung Cancer 31:213–219
Sezer O, Jakob C, Eucker J, Niemoller K, Gatz F, Wernecke K, Possinger K (2001) Serum levels of the angiogenic cytokines basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) in multiple myeloma. Eur J Haematol 66:83–88
Ugurel S, Rappl G, Tilgen G, Reinhold U (2001) Increased serum concentration of angiogenic factors in malignant melanoma patients correlates with tumor progression and survival. J Clin Oncol 19:577–583
Dietz A, Rudat V, Conradt C, Weidauer H, Ho A, Moehler T (2000) Prognostic relevance of serum levels of the angiogenic peptide bFGF in advanced carcinoma of the head and neck treated by primary radiochemotherapy. Head Neck 22:666–673
Davies MM, Jonas SK, Kaur S, Allen-Mersh TG (2000) Plasma vascular endothelial but not fibroblast growth factor levels correlate with colorectal liver metastasis vascularity and volume. Br J Cancer 82:1004–1008
Darai E, Bringuier AF, Walker-Combrouze F, Feldman G (1998) Soluble adhesion molecules in serum and cyst fluid from patients with cystic tumours of the ovary. Hum Reprod 13:2831–2835
Liu CM, Sheen TS, Ko JY, Shun CT (1999) Circulating intercellular adhesion molecule 1 (ICAM-1) E-selectin and vascular cell adhesion molecule 1 (VCAM-1) in head and neck cancer. Br J Cancer 79:360–362
Okamoto Y, Tsurunaga T, Ueki M (1999) Serum soluble ICAM-1 levels in the patients with cervical cancer. Acta Obstet Gynecol Scand 78:60–65
Sun JJ, Zhou XD, Liu YK, Tang ZY, Feng JX, Zhou G, Xue Q, Chen J (1999) Invasion and metastasis of liver cancer. Expression of intercellular adhesion molecule 1. J Cancer Res Clin Oncol 125:28–34
Huang YS, Wu JC, Chan CY, Chao Y, Chang FY, Lee SD (1999) Circulating intercellular adhesion molecule-1 in chronic liver disease and hepatocellular carcinoma. Zhonghua Yi Xue Za Zhi (Taipei) 62:487–495
DeVita F, Infusino S, Auriemma A, Orditura M, Catalan AU (1998) Circulating levels of soluble intercellular adhesionmolecule-1 in non-small cell lung cancer patients. Oncol Rep 5:393–396
Grothey A, Heistermann P, Philippou S, Voigtman R (1998) Serum levels of soluble intercellular adhesion molecule-1 (ICAM-1, CD54) in patients with non small cell lung cancer: correlation with histological expression of ICAM-1 and tumour stage. Br J Cancer 77:801–807
Kaihara A, Iwagaki H, Gouchi A, Hizuta A, Isozaki H, Takakura N, Tanaka N (1998) Soluble intercellular adhesion molecule-1 and natural killer cell activity in gastric cancer patients. Res Commun Mol Pathol Pharmacol 100: 283–300
Kitagawa T, Matsumoto K, Iriyama K (1998) Serum cell adhesion molecules in patients with colorectal cancer. Surg Today 28:262–267
Byrne GJ, Ghellal A, Iddon J, Blann AD, Venizelos V, Kumar S, Howell A, Bundred NJ (2000) Serum soluble vascular cell adhesion molecule-1: role as a surrogate marker of angiogenesis. J Natl Cancer Inst 92:1329–1336
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Pasieka, Z., Stępień, H., Komorowski, J., Kołomecki, K., Kuzdak, K. (2003). Evaluation of the Levels of bFGF, VEGF, sICAM-1, and sVCAM-1 in Serum of Patients with Thyroid Cancer. In: Allgayer, H., Heiss, M.M., Schildberg, F.W. (eds) Molecular Staging of Cancer. Recent Results in Cancer Research, vol 162. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59349-9_18
Download citation
DOI: https://doi.org/10.1007/978-3-642-59349-9_18
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-63945-6
Online ISBN: 978-3-642-59349-9
eBook Packages: Springer Book Archive