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Modulation of Myofibroblast and Smooth-Muscle Phenotypes in the Lung

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Tissue Repair and Fibrosis

Part of the book series: Current Topics in Pathology ((CT PATHOLOGY,volume 93))

Abstract

The lung contains a full complement of vascular and visceral smooth-muscle cells (SMCs) [2, 16, 18]. Additionally, in the normal alveolar wall, there are contractile interstitial cells that contribute to normal function [10, 12] as well as to alveolar remodeling seen in such disorders as pulmonary hypertension and interstitial fibrosis [11, 21]. This review will present three topics: (1) the differentiation of these cells during normal lung development, (2) the phenotypic changes that occur during pulmonary interstitial remodeling, including the appearance of alveolar and interstitial myofibroblasts during pulmonary fibrosis, and (3) the regulation of cell phenotype by transforming growth factor-β (TGF-β). Other chapters in this volume also are particularly relevant to what is covered here (Chaps. 1, 5, 6, 15, 18).

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Authors
  1. R. B. Low
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Editors and Affiliations

  1. GREF, Université Victor Segalen Bordeaux 2, 146, Rue Léo-Saignat, 33076, Bordeaux Cedex, France

    Alexis Desmoulière

  2. Départment de Nutrition, Université de Montréal, Pavillon Liliane-de-Stewart C. P. 6128, Succursale Centre-Ville, Montréal, Québec, H3C 3J7, Canada

    Beatriz Tuchweber

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© 1999 Springer-Verlag Berlin Heidelberg

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Low, R.B. (1999). Modulation of Myofibroblast and Smooth-Muscle Phenotypes in the Lung. In: Desmoulière, A., Tuchweber, B. (eds) Tissue Repair and Fibrosis. Current Topics in Pathology, vol 93. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58456-5_3

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  • DOI: https://doi.org/10.1007/978-3-642-58456-5_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63603-5

  • Online ISBN: 978-3-642-58456-5

  • eBook Packages: Springer Book Archive

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