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Regulation of Heat Shock Genes by Ischemia

  • Chapter
Stress Proteins

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 136))

Abstract

The evolutionarily conserved and ubiquitous nature of the heat shock response is well established. However, perhaps nowhere is the potential heterogeneity of this response more evident than in the brain. Several recent reviews provide detailed evaluations of the heat shock response following ischemia and other brain insults (Abe and Nowak 1996b; Massa et al. 1996; Planas et al. 1997). As documented in these, as well as below and elsewhere in this volume (see Chaps. 9,11, and 12), different insults induce a given heat shock gene with differing cell type specificities, and an ischémic insult can result in divergent patterns of expression of individual heat shock genes, implying distinct regulatory mechanisms. Furthermore, impaired translation is a prominent feature of ischemic injury in brain, and this imposes a significant limitation on the expression of proteins encoded by ischemia-induced mRNAs.

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Authors
  1. T. S. Nowak Jr.
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  2. Q. Zhou
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  3. W. J. Valentine
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  4. J. B. Harrub
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  5. H. Abe
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Editors and Affiliations

  1. Department of Molecular Pathology, University College London, Cleveland Street, London, W1P 6DB, UK

    David S. Latchman M.A. Ph.D., D.Sc. (Head, Director) (Head, Director)

  2. Windeyer Institute of Medical Sciences, University College London, Cleveland Street, London, W1P 6DB, UK

    David S. Latchman M.A. Ph.D., D.Sc. (Head, Director) (Head, Director)

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Nowak, T.S., Zhou, Q., Valentine, W.J., Harrub, J.B., Abe, H. (1999). Regulation of Heat Shock Genes by Ischemia. In: Latchman, D.S. (eds) Stress Proteins. Handbook of Experimental Pharmacology, vol 136. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58259-2_8

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  • DOI: https://doi.org/10.1007/978-3-642-58259-2_8

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