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Catharanthus roseus L. (Periwinkle): Production of Vindoline and Catharanthine in Multiple Shoot Cultures

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Medicinal and Aromatic Plants VI

Part of the book series: Biotechnology in Agriculture and Forestry ((AGRICULTURE,volume 26))

Abstract

The periwinkle, Catharanthus roseus, is a member of the family Apocynaceae and belongs to the subfamily Plumerioideae. This plant is native to Madagascar, but is cultivated as an ornamental plant throughout tropical and subtropical areas, and has been abundantly naturalized in many parts of the world Stearn 1975; Morton 1976. The plant has many uses in folk medicine in tropical areas Morton 1976. For example, gargling with an infusion of the plant is considered to relieve pain from a sore throat, laryngitis, and chest complaints in Central America. Juice squeezed from the leaves is applied to wasp stings in India.

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References

  • Constabel FG, Laprairie P, Kurz WGW, Kutney JP (1982) Alkaloid production in Catharanthus roseus cell cultures. XII. Biosynthetic capacity of callus from original expiants and regenerated shoots. Plant Cell Rep 1:139–142

    Google Scholar 

  • DiCosmo F (1990) Strategies to improve yields of secondary metabolites to industrially interesting levels. In: Nijkamp HJJ, van der Plas LHW, van Aartrijk J (eds) Progress in plant cellular and molecular biology. Kluwer, Dordrecht, pp 717–725

    Google Scholar 

  • Drapeau D, Blanch HW, Wilke CR (1987) Ajmalicine, serpentine and catharanthine accumulation in Catharanthus roseus bioreactor cultures. Planta Med 53:373–376

    Article  PubMed  CAS  Google Scholar 

  • Eilert U, Constabel F, Kurz WGW (1986) Elicitor stimulation of monoterpene indole alkaloid formation in suspension cultures of Catharanthus roseus. J Plant Physiol 126:11–22

    Article  CAS  Google Scholar 

  • Endo T, Goodbody A, Misawa M (1987) Alkaloid production in root and shoot cultures of Catharanthus roseus. Planta Med 53:479–482

    Article  PubMed  CAS  Google Scholar 

  • Facchini P, Dicosmo F (1991) Secondary metabolite biosynthesis in cultured cells immobilized by adhesion to glass fibers. Appl Microbiol Biotechnol 35:382–392

    Article  PubMed  CAS  Google Scholar 

  • Fujita Y, Hara Y, Morimoto T, Misawa M (1990) Semisynthetic production of vinblastine involving cell cultures of Catharanthus roseus and chemical reaction. In: Nijkamp HJJ, van der Plas LHW, van Aartrijk J (eds) Progress in plant cellular and molecular biology. Kluwer, Dordrecht, pp 738–743

    Google Scholar 

  • Goodbody AE, Endo T, Vukovic J, Kutney JP, Choi LSL, Misawa M (1988) Enzymic coupling of catharanthine and vindoline to form 3′,4′-anhydrovinblastine by horseradish peroxidase. Planta Med 54:136–140

    Article  PubMed  CAS  Google Scholar 

  • Hirata K, Yamanaka A, Kurano N, Miyamoto K, Miura Y (1987) Production of indole alkaloids in multiple shoot cultures of Catharanthus roseus (L). G. Don. Agric Biol Chem 51:1311–1317

    Article  CAS  Google Scholar 

  • Hirata K, Horiuchi M, Ando T, Miyamoto K, Miura Y (1990) Vindoline and catharanthine production in multiple shoot cultures of Catharanthus roseus. J Ferment Bioeng 70:193–195

    Article  CAS  Google Scholar 

  • Hirata K, Horiuchi M, Ando T, Asada M, Miyamoto K, Miura Y (1991) Effect of near-ultraviolet light on alkaloid production in multiple shoot cultures of Catharanthus roseus. Planta Med 57:499–500

    Article  PubMed  CAS  Google Scholar 

  • Krueger RJ, Carew DP, Lui JHC, Staba EJ (1982) Initiation, maintenance and alkaloid content of Catharanthus roseus leaf organ cultures. Planta Med 48:56–57

    Article  Google Scholar 

  • Kutney JP (1990) Biosynthesis and synthesis of indole and bisindole alkaloids in plant cell cultures: a personal overview. Nat Prod Rep 7:85–103

    Article  CAS  Google Scholar 

  • Kutney JP, Boulet CA, Choi LSL, Gustowski W, Mchugh M, Nakano J, Nikaido T, Tsukamoto H, Hewitt GM, Suen R (1988) Alkaloid production in Catharanthus roseus (L.) G. Don cell cultures. XV. Synthesis of bisindole alkaloids by use of immobilized enzyme systems. Heterocycles 27:621–628

    CAS  Google Scholar 

  • Miura Y, Hirata K, Kurano N, Miyamoto K, Uchida K (1988) Formation of vinblastine in multiple shoot culture of Catharanthus roseus. Planta Med 54:18–20

    Article  PubMed  CAS  Google Scholar 

  • Morton JF (1976) Periwinkle. In: Morton JF (ed) Major medicinal plants, botany, culture and uses. Charles C Thomas, Springfield, Illinois, pp 237–241

    Google Scholar 

  • Nef C, Rio B, Chrestin H (1991) Induction of catharanthine synthesis and stimulation of major indole alkaloid production by Catharanthus roseus cells under non-growth-altering treatment with Pythium vexans extracts. Plant Cell Rep 10:26–29

    Article  CAS  Google Scholar 

  • Park HH, Choi SK, Kang JK, Lee HY (1990) Enhancement of producing catharanthine by suspension growth of Catharanthus roseus. Biotechnol Lett 12:603–608

    Article  CAS  Google Scholar 

  • Smith JI, Smart NJ, Kurz WGW, Misawa M (1987a) Stimulation of indole alkaloid production in cell suspension cultures Catharanthus roseus by abscisic acid. Planta Med 53:470–474

    Article  PubMed  CAS  Google Scholar 

  • Smith JI, Quesnel AA, Smart NJ, Misawa M (1987b) The development of a single-stage growth and indole alkaloid production medium for Catharanthus roseus (L.) G. Don suspension cultures. Enzyme Microb Technol 9:466–469

    CAS  Google Scholar 

  • Smith JI, Smart NJ, Misawa M, Kurz WGW, Tallevi SG, Dicosmo F (1987c) Increased accumulation of indole alkaloids by some cell lines of Catharanthus roseus in response to addition of vanadyl sulphate. Plant Cell Rep 6:142–145

    Article  CAS  Google Scholar 

  • Stearn WT (1975) A synopsis of the genus Catharanthus (Apocynaceae). In: Taylor W, Farnsworth NR (eds) The catharanthus alkaloids. Dekker, New York, pp 9–44

    Google Scholar 

  • Svoboda GH (1975) The phytochemistry and pharmacology of Catharanthus roseus (L.) G. Don. In: Taylor W, Farnsworth NR (eds) The catharanthus alkaloids. Dekker, New York, pp 45–83

    Google Scholar 

  • Tallevi S, Dicosmo F (1988) Stimulation of indole alkaloid content in vanadium-treated Catharanthus roseus suspension cultures. Planta Med 54:149–152

    Article  PubMed  CAS  Google Scholar 

  • Tom R, Jardin B, Chavarie C, Archambault J (1991) Effect of culture process on alkaloid production by Catharanthus roseus cells. I. Suspension cultures. J Biotechnol 21:1–20

    CAS  Google Scholar 

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© 1994 Springer-Verlag Berlin Heidelberg

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Hirata, K., Miyamoto, K., Miura, Y. (1994). Catharanthus roseus L. (Periwinkle): Production of Vindoline and Catharanthine in Multiple Shoot Cultures. In: Bajaj, Y.P.S. (eds) Medicinal and Aromatic Plants VI. Biotechnology in Agriculture and Forestry, vol 26. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57970-7_3

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  • DOI: https://doi.org/10.1007/978-3-642-57970-7_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63420-8

  • Online ISBN: 978-3-642-57970-7

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