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Thermal Dosimetry

  • Chapter
Thermoradiotherapy and Thermochemotherapy

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

Implementation of thermal dosimetry requires three steps. First, it is necessary to use accurate thermometers. This subject is covered in Chap. 15 of this volume. Second, it is necessary to use a measure of treatment effect that has biological significance (i.e., there is a quantitative relationship between the measure of treatment delivered and the cytotoxic effect of the treatment). A large database from in vitro and in vivo models has provided useful concepts for this aspect of dosimetry, although recent data from human cells suggest that some key revisions to the concepts may be necessary. In this chapter the relations between temperature, time at temperature, and cytotoxicity will be reviewed. In addition, factors that are known to influence the accuracy of these measures of effect will be presented, along with an emphasis on their clinical relevance.

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Author information

Authors and Affiliations

  1. Tumor Microcirculation Laboratory, Department of Radiation Oncology, Duke University Medical Center, P.O. Box 3455, Durham, NC, 27710, USA

    M. W. Dewhirst DVM, PhD

Authors
  1. M. W. Dewhirst DVM, PhD
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Editor information

Editors and Affiliations

  1. Strahlentherapeutische Klinik, Universität Erlangen-Nürnberg, Universitätsstraße 27, 91054, Erlangen, Germany

    M. Heinrich Seegenschmiedt

  2. Radiation Oncology Physics Division, Stanford University Medical Center, SUMC Room S-044, Stanford, CA, 94305, USA

    Peter Fessenden PhD (Professor Emeritus, Radiation Oncology) (Professor Emeritus, Radiation Oncology)

  3. Department of Clinical Oncology, Hammersmith Hospital, Ducane Road, London, W12 OHS, UK

    Clare C. Vernon MA, FRCR

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© 1995 Springer-Verlag Berlin Heidelberg

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Dewhirst, M.W. (1995). Thermal Dosimetry. In: Seegenschmiedt, M.H., Fessenden, P., Vernon, C.C. (eds) Thermoradiotherapy and Thermochemotherapy. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57858-8_6

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  • DOI: https://doi.org/10.1007/978-3-642-57858-8_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63382-9

  • Online ISBN: 978-3-642-57858-8

  • eBook Packages: Springer Book Archive

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