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Toxikologie von D-Campher

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Phytopharmaka VI

Zusammenfassung

Natürlicher D-Campher wurde in China bereits vor unserer Zeitrechnung aus dem Holz des Campherbaumes gewonnen und medizinisch verwendet. In einer der ersten deutschsprachigen Monographien über Campher aus dem [ahr 1793 [5] wird die Substanz als „Belebungsmittel“ bezeichnet und ein entsprechender Anwendungsfall berichtet. Über die toxischen Eigenschaften wird ausgeführt, dass bei gesunden Menschen, die größere Dosen Campher eingenommen hatten, Betrunkenheit, Schwindel, Magenbrennen, langsamer Puls, Schläfrigkeit und Krämpfe auftraten.

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Literatur

  1. Bavoux F, Bodiou C, Castot A, Chercouri A, Cote B, Dupeyron J-P, Frelon J-H, Huault G, Lanfranchi C, Lefebure B, Medernach C, O’Byrne P, Vignes B (1985) Le camphre en pédiatrie. Therapie 40:25–30

    PubMed  CAS  Google Scholar 

  2. Blackmon WP, Curry HB (1967) Camphor poisoning: Report of case occurring during pregnancy. J Florida Med Assoc 43:999–1000

    Google Scholar 

  3. Bruchhausen R, Ebel S, Frahm AW, Hackenthal E (Hrsg) (1993) Hager’s Handbuch der Pharmazeutischen Praxis Bd. 7. Springer, Berlin Heidelberg New York, S 645–650

    Google Scholar 

  4. Christensen BV, Lynch HJ (1937) A comparative study of the pharmacological actions of natural and synthetic camphor. J Am Pharm Ass 26:786–794

    Article  CAS  Google Scholar 

  5. Dörffurth AFL (1793) Abhandlung über den Campher. Samuel Gottfried Zimmermann, Wittenberg und Zerbst, S 1-34.

    Google Scholar 

  6. Ezeyza S (1952) Carencia de poder canzerigeno del guayacol, alcanfor y ruibarbo e intensa acción irritativa del ultimo, probados subcutáneamente en ratas. Semana Med 100:663–666

    CAS  Google Scholar 

  7. Flury F, Zernik-Wurzburg F (1928) Zusammenstellung der toxischen und letalen Dosen für die gebräuchlichsten Gifte und Versuchstiere. In: Abderhalden E (ed) Handbuch der biologischen Arbeitsmethoden. Abt. IV. Angewandte chemische und physikalische Methoden. Urban und Schwarzenberg, Berlin, Part 7, no. 7 1318 (1928) zitiert in: Opdyke DLJ (1978) Camphor USP. Fragrance raw materials monographs. Food Cosmet Toxicol 16: 665-671

    Google Scholar 

  8. Fühner H (1932) Beiträge zur vergleichenden Pharmakologie. I. Die giftigen und tödlichen Gaben einiger Substanzen für Frösche und Mäuse. Naunyn-Schmiedebergers Arch Exp Pathol Pharmakol 166:437 zitiert in: Opdyke DLJ (1978) Camphor USP Fragrance raw materials monographs. Food Cosmet Toxicol 16:665-671

    Google Scholar 

  9. Geller RJ, Spyker DA, Garrettson LK, Rogol AD (1984) Camphor toxicity: development of a triage strategy. Vet Hum Toxicol 26(2):8–10

    PubMed  Google Scholar 

  10. Gibson DE, More GP, Pfaff JA (1989) Camphor ingestion. Am J Emergency Med 7:41–43

    Article  CAS  Google Scholar 

  11. Gomes-Carneiro MR, Felzenswalb I, Paumgartten FJR (1998) Mutagenicity testing of (±)-camphor, 1,8-cineole, citral, citronellal, (-)-menthol and terpineol with the Salmonella/ microsome assay. Mutat Res 416:129–136

    Article  PubMed  CAS  Google Scholar 

  12. Gosselin RE, Smith RP, Hodge HC, Braddock JE (1985) Clinical toxicology of commercial products, 5th edn. Williams & Wilkins, Baltimore London, pp 84–86

    Google Scholar 

  13. Gossweiler B (1982) Kampfervergiftungen heute. Schweiz Rundschau Med (Praxis) 71:1475–1478

    CAS  Google Scholar 

  14. Hempel B (1999) Wissenschaftliches Erkenntnismaterial zu Cinnamomum camphora. Kooperation Phytopharmaka, Bonn

    Google Scholar 

  15. Horikawa E, Okada T (1975) Experimental study on acute toxicity of phenol camphor. J Tokyo Dental Coll Soc 75:934–939

    CAS  Google Scholar 

  16. Jacobziner H, Raybin HW (1959) Briefs on accidental chemical poisonings in New York City. Oil of wintergreen, camphor, and lye ingestions. New York Stat J Med 59:115–118

    Google Scholar 

  17. Jimenez JF, Brown AL, Arnold WC, Byrne WJ (1983) Chronic camphor ingestion mimicking Reye’s syndrome. Gastroenterology 84:394–398

    PubMed  CAS  Google Scholar 

  18. Joly C, Bouillie C, Hummel M (1980) Intoxication aigue par le camphre administré par voie externe chez un nourrisson. Ann Pédiat 27:395–396

    PubMed  CAS  Google Scholar 

  19. Köppel C, Tenczer J, Schirop T, Ibe K (1982) Camphor poisoning. Abuse of camphor as a stimulant. Arch Toxicol 51:101–106

    Article  Google Scholar 

  20. Leuschner J (1997) Reproductive toxicity studies of D-camphor in rats and rabbits. Arzneimittelforschung 47:124–128

    PubMed  CAS  Google Scholar 

  21. Leuschner J (1997) Examination of D-camphor on convulsions in mice following oral administration (safety pharmacology study). LPT-report Nr. 10142/96 vom 11.04. 1997 an die Firma Robugen GmbH, D-73730 Esslingen

    Google Scholar 

  22. Magrupova MA, Kamilov IK, Polievtsev NP (1962) Antagonism between haplophyllidin and analeptics. Farmakol Alkaloidov Akad Nauk Uz SSR Inst khim rast Veshch no 1: 169 (1962) zitiert in: Opdyke, DLJ Camphor (1978) USP Fragrance raw materials monographs. Food Cosmet Toxicol 16:665-671.

    Google Scholar 

  23. Mercier C, Martin L, Autret E, Weill D, Maurage C, Robert M (1984) A propos des dangers des pansements camphrés chez l’enfant. Arch Fr Pediatr 41:74

    PubMed  CAS  Google Scholar 

  24. Moreno OM (1976) Report to RIFM, 5. January (1976) zitiert in Opdyke, DLJ (1978) Camphor USP. Fragrance raw materials monographs. Food Cosmet Toxicol 16:665-671.

    Google Scholar 

  25. Navarro HA, Price CJ, Marr MC, Myers CB, Heindel JJ (1992) Developmental toxicity evaluation of ‘d’-camphor (CAS No. 464-49-3) administered by gavage to sprague-dawley (CD(trade name)) rats on gestational days 6 through 15. Final study report and appendix. National Toxicology Program, Research Triangle Park, NC (1992) PB92-170034.

    Google Scholar 

  26. Navarro HA, Price CJ, Marr MC, Myers CB, Heindel JJ (1992) Final report on the developmental toxicity of ‘d’-camphor (CAS No. 464-49-3) in New Zealand White (NZW) (trade name) rabbits. National Toxicology Program, Research Triangle Park, NC (1992) PB93-123784.

    Google Scholar 

  27. Purchase IFH, Longstaff E, Ashby J, Styles JA, Anderson D, Lefevre PA, Westwood FR (1978) An evaluation of 6 short-term tests for detecting organic chemical carcinogens. Br J Kanzer 37:873–903

    Article  CAS  Google Scholar 

  28. Riggs J, Hamilton R, Homel S, McCabe J (1965) Camphorated oil intoxication in pregnancy. Report of a case. Obstet Gynecol 25:255–258

    PubMed  CAS  Google Scholar 

  29. Sampson WL, Fernandez L (1939) Experimental convulsions in the rat. J Pharmacol Exp Therap 65:275–280

    CAS  Google Scholar 

  30. Siegel E, Wason S (1986) Camphor toxicity. Pediatr Clin North America 33:375–379

    CAS  Google Scholar 

  31. Skoglund RR, Ware LL, Schanberger JE (1977) Prolonged seizures due to contact and inhalation exposure to camphor. Clin Pediatr 16:901–902

    Article  CAS  Google Scholar 

  32. Smith AG, Margolis G (1954) Camphor poisoning. Anatomical and pharmalogic study; report of a fatal case; experimental investigation of protective action of barbiturate. Am J Pathol 30:857–869

    PubMed  CAS  Google Scholar 

  33. Sollmann Th, Hanzlik PJ (1939) Fundamentals of experimental pharmacology. JW Stacey, Inc. San Francisco 307 pp. zitiert in: Smith AG, Margolis G (1954) Camphor poisoning. Anatomical and pharmacologic study; report of a fatal case; experimental investigation of protective action of barbiturate. Am J Pathol 30:857-869

    Google Scholar 

  34. Stoner GD, Shimkin MG, Kniazeff AJ, Weisburger JH, Weisburger EK, Gori GB (1973) Test for canzerogenicity of food additives and chemotherapeutic agents by the pulmonary tumor response in strain A mice. Canzer Research 33:3069–3085

    CAS  Google Scholar 

  35. Weiss J, Catalano P (1973) Camphorated oil intoxication during pregnancy. Pediatrics 52:713–714

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Robugen GmbH Pharmazeutische Fabrik, Esslingen, Germany

    B. Hempel

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  1. B. Hempel
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  1. Am Sellsiekbach 52, 32657, Lemgo, Germany

    Norbert Rietbrock

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© 2000 Springer-Verlag Berlin Heidelberg

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Hempel, B. (2000). Toxikologie von D-Campher. In: Rietbrock, N. (eds) Phytopharmaka VI. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-57735-2_4

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  • DOI: https://doi.org/10.1007/978-3-642-57735-2_4

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-642-63340-9

  • Online ISBN: 978-3-642-57735-2

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