Abstract
Daily variations in the cardiovascular system are well documented from the carcadian rhythm in blood pressure and heart rate, pathophysiological events such as coronary infarction, angina pectoris down to the receptor-mediated processes of signal transduction. Telemetric data on blood pressure and heart rate profiles in animal models of human primary and secondary hypertension together with biochemical and molecular biological findings can help to get a better understanding of the mechanisms involved in the circadian organization of the cardiovascular system. From animal data of genetically different strains of rats (normotensive, hypertensive, transgenic hypertensive rats), we have good evidence that the master clock located in the nucleus suprachiasmaticus (SCN) is involved in the rhythmic organization. Chronopharmacological studies with different kinds of antihypertensive drugs also point to a genetically bound variation in the circadian pattern of blood pressure and its regulation.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Aschoff J (1963) Gesetzmäβigkeiten der biologischen Tagesperiodik. Dtsch med Wschr 88: 1930–1937
Aschoff J (1965) Circadian Clocks. Amsterdam: North-Holland
Coats AJS (1996) Benefits of ambulatory blood pressure monitoring in the design of antihypertensive drug trials. Blood Pressure Monitoring 2:157–160
Cugini P, Kawasaki T, DiPalma L, Antonicoli S, Battisti P, Coppola A, Leone G (1989) Preventive distinction of patients with primary or secondary hypertension by discriminant analysis of chronobiologic parameters on 24-h blood pressure patterns. Jpn Circ J 53:1363–1370
Del Rosso G, Amoroso L, Santoferrara A, Fiederling B, Di LIberato L, Albertazzi A (1994) Impaired blood pressure nocturnal decline and target organ damage in chronic renal failure. J Hypertens 12 (Suppl 3):S15
Hauptfleisch S, Schummer B, Lemmer B (1998) Expression of c-fos messenger-RNA involved in the regulation of blood pressure in normotensive and transgenic hypertensive rats. Naunyn-Schmiedeberg’s Arch Pharmacol 357, R 17
Hauptfleisch S, Schummer B, Lemmer B (1998) Is a neuronal pacemaker involved in the regulation of blood pressure rhythm? Expression pattern of mRNA in the suprachiasmatic nuclei in normotensive and transgenic hypertensive rats. Am J Hyperten 11: 140A
Lemmer B (1989) Temporal aspects in the effects of cardiovascular active drugs in man. In: Lemmer B (ed) Chronopharmacology — Cellular and Biochemical Interactions. Marcel Dekker, New York, pp 525–542
Lemmer B (1995) of cardiovascular medications - pitfalls and challenges. Brit J Cardiol 2:303–309
Lemmer B (1996) Circadian rhythm in blood pressure: Signal transduction, regulatory mechanisms and cardiovascular medication. In: Lemmer B (ed) From the Biological Clock to Chronopharmacology. Stuttgart: Medpharm Publ, pp 91–117
Lemmer B (1996) Differential effects of antihypertensive drugs on circadian rhythm in blood pressure from the chronobiological point of view. Blood Pressure Monitoring 1:161–169
Lemmer B, Boese S, Mattes A (1993) Wirkung von Doxazosin auf circadiane Rhythmen im Blutdruck normotensiver und hypertensiver Ratten. Z Kardiol Suppl 1:139
Lemmer B, Bruguerolle B (1994) Chronopharmacokinetics — are they clinically relevant? Clin Pharmacokinet 26: 419–427
Lemmer B, Lang P-H, Schmidt S, Bärmeier H (1987) Evidence for circadian rhythmicity of the beta-adrenoceptor - adenylate cyclase - cAMP-phosphodiesterase system in the rat. J Cardiovasc Pharmacol 10: 138–140
Lemmer B, Mattes A, Boese S (1992) Dose-dependent effects of amlodipine on 24-hour rhythms in blood pressure and heart rate in the normotensive and hypertensive rat. Am J Hyperten 5:110A
Lemmer B, Mattes A, Boese S, Laufen H (1993) On the circadian time dependency in the pharmacokinetics of the calcium channel blocker amlodipine in plasma and various organs of the rat. 21th Conference Int Soc Chronobiol, Quebec, Canada, Abstr XI-3
Lemmer B, Mattes A, Böhm M, Ganten D (1993) Circadian blood pressure variation in transgenic hypertensive rats. Hypertension 22:97–101
Lemmer B, Portaluppi F (1997) Chronopharmacology of cardiovascular diseases. In: Redfern P, Lemmer B (eds) Handbook of Experimental Pharmacology, Vol 125 Physiology and Pharmacology of Biological Rhythms. Springer, Heidelberg, New York, pp 251–297
Lemmer B, Witte K (1997) Telemetric data acquisition of cardiovascular functions in biology and pharmacology. In: van Zutphen LFM, Balls M (eds) Animal Alternatives, Welfare and Ethics, Elsevier, Amsterdam, New York, pp 311–320
Lemmer B, Witte K, Makabe T, Ganten D, Mattes A (1994) Effects of enalaprilat on circadian profiles in blood pressure and heart rate of spontaneously and transgenic hypertensive rats. J Cardiovasc Pharmacol 23: 311–314
Lemmer B, Witte K, Minors D, Waterhouse J (1995) Circadian rhythms of heart rate and blood pressure in four strains of rat: Differences due to, and separate from, locomotor activity. Biol Rhythm Res 26: 493–504
Mattes A, Lemmer B (1991) Effects of amlodipine on circadian rhythms in blood pressure, heart rate, and motility: A telemetric study in rats. Chronobiol Int 8: 526–538
Mattes A, Witte K, Hohmann W, Lemmer B (1991) PHARMFIT — a nonlinear fitting program for pharmacology. Chronobiol Int 8: 460–476
Middeke M, Schrader J (1994) Nocturnal blood pressure in normotensive subjects and those with white coat, primary, and secondary hypertension. Brit Med J 308: 630–632
Minors D, Witte K, Lemmer B, Atkinson G, Waterhouse J (1998) The correlation between activity, blood pressure and heart rate in freely mobile Sprague-Dawley and transgenic rats. Biol Rhythm Res 29: 213–227
Pickering TG (1996) A review of national guidelines on the clinical use of ambulatory blood pressure monitoring. Blood Pressure Monitoring 2: 151–156
Portaluppi F, Cortelli P, Avoni P, Vergnani L, Contin E, Maltoni P, Pavani A, Sforza E, degli Uberti EC, Gambetti P, Lugaresi E (1994) Diurnal blood pressure variation and hormonal correlates in fatal familial insomnia. Hypertension 23: 569–576
Schnecko A, Witte K, Lemmer B (1995) Effects of the angiotensin II receptor antagonist losartan on 24-hour blood pressure profiles of primary and secondary hypertensive rats. J Cardiovasc Pharmacol 26: 214–221
Verdecchia P, Schillaci G, Guerrieri M, Gatteschi C, Benemio G, Boldrini F, Porcellati C (1990) Circadian blood pressure changes and left ventricular hypertrophy in essential hypertension [see comments]. Circulation 81: 528–536
White WB (1996) Clinical relevance of ambulatory versus clinic blood pressure when evaluating antihypertensive therapy. Blood Pressure Monitoring 2: 170–173
Willich SN, Muller JE (eds) (1996) Triggering of Acute Coronary Syndromes. Kluwer, Dordrecht, The Netherlands
Witte K, Lemmer B (1995) Free-running rhythms in blood pressure and heart rate in normotensive and transgenic hypertensive rats. Chronobiol Int 12: 237–247
Witte K, Lemmer B (1996) Signal transduction in animal models of normotension and hypertension. Time-dependent structure and control of arterial blood pressure. Ann NY Acad Sci 783: 71–83
Witte K, Lemmer B (1997) Rhythms in second messenger mechanisms. In: Redfern P, Lemmer B (eds) Handbook of Experimental Pharmacology, Vol 125 Physiology and Pharmacology of Biological Rhythms. Springer, Heidelberg, New York, pp 135–156
Witte K, Parsa-Parsi R, Vobig M, Lemmer B (1995) Mechanisms of the circadian regulation of β-adrenoceptor density and adenylyl cyclase activity in cardiac tissue from normotensive and spontaneously hypertensive rats. J Mol Cell Cardiol 27: 1195–1202
Witte K, Schnecko A, Buijs RM, Vliet J van der, Scalbert E, Delagrange Ph, Guardiola-Lemaitre, Lemmer B (1998) Effects of SCN-lesions on circadian blood pressure rhythm in normotensive and transgenic hyper- tensive rats. Chronobiol Int 15: 135–145
Witte K, Schnecko A, Perbandt K, Höfer S, Lemmer B (1998) Signal transduction in cardiac and vascular tissue from normotensive and transgenic hypertensive TGR(mREN2)27 rats. Eur J Pharmacol 341: 337–341
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2000 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Lemmer, B. (2000). Genetic aspects of chronobiologic rhythms in cardiovascular disease. In: Zehender, M., Just, H., Breithardt, G. (eds) From Molecule to Men. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-57724-6_17
Download citation
DOI: https://doi.org/10.1007/978-3-642-57724-6_17
Publisher Name: Steinkopff, Heidelberg
Print ISBN: 978-3-642-63338-6
Online ISBN: 978-3-642-57724-6
eBook Packages: Springer Book Archive