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Risk factors for schizophrenia in childhood and youth

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Risk and Protective Factors in Schizophrenia

Abstract

The syndrome we call schizophrenia usually always appears in early to mid-adult life [24, 51, 52]. However, there is ample evidence that those who will develop it are a little different from their peers long before this, at a much earlier stage of the life course. These differences may be the manifestations of the same causes that later lead to schizophrenia, they may be distinct from these effects, or they may be the age-related, non-psychotic manifestations of schizophrenia itself; we don’t know.

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References

  1. Albee GW, Lane EA, Corcoran C, Werneke A (1963) Childhood and inter-current intellectual performance of adult schizophrenics. J Consult Psychology 27 (4): 364–366

    Article  CAS  Google Scholar 

  2. Ambelas A (1992) Preschizophrenics: adding to the evidence, sharpening the focus. Br J Psychiatry 160: 401–404

    Article  PubMed  CAS  Google Scholar 

  3. American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders. Third Edn - Revised. Washington, DC: American Psychiatric Association

    Google Scholar 

  4. Andreasson S, Allebeck P, Engstrom A, Rydberg U (1987) Cannabis and schizophrenia. A longitudinal study of Swedish conscripts. Lancet ií:1483–1486

    Google Scholar 

  5. Aylward E, Walker E, Bettes B (1984) Intelligence in schizophrenia: meta-analysis of the research. Schizophrenia Bull 10: 430–459

    Article  CAS  Google Scholar 

  6. Barker DJP (1992) (ed) Fetal & Infant Origins of Adult Disease. Papers written by the Medical Research Council Environmental Epidemiology Unit London: Br Med J

    Google Scholar 

  7. Barker DJP, Osmond C (1986) Childhood respiratory infection and chronic bronchitis in England and Wales. Br Med J 293: 1271–1275

    Article  CAS  Google Scholar 

  8. Barker DJP, Winter PD, Osmond C, Margetts B, Simmonds SJ (1989) Weight in infancy and death from ischaemic heart disease. Lancet ii: 577–580

    Google Scholar 

  9. Barker DJP, Bull AR, Osmond C, Simmonds SJ (1990) Fetal and placental size and risk of hypertension in adult life. Br Med J 301: 259–262

    Article  CAS  Google Scholar 

  10. Bleuler E (1908) Die Prognose der Dementia Praecox - Schizophreniegruppe. Allgemeine Zeitschrift fur Psychiatrie 65: 436–464. Translated in: Cutting J, Shepherd M (eds) The Clinical Roots of the Schizophrenia Concept (1987). Cambridge CUP pp 59–74

    Google Scholar 

  11. Bleuler E (1911) Dementia praecox oder Gruppe der Schizophrenien. Deuticke, Leipzig, Vienna

    Google Scholar 

  12. Boyd JH, Pulver AE, Stewart W (1986) Season of birth: schizophrenia and bipolar disorder. Schizophrenia Bull 12: 173–185

    Article  CAS  Google Scholar 

  13. Bradbury TN, Miller GA (1985) Season of birth in schizophrenia: a review of evidence, methodology, and etiology. Psychological Bulletin 98: 569–594

    Article  PubMed  CAS  Google Scholar 

  14. Brown AS, Susser E, Cohen P (1997) Psychosis after prenatal exposure to rubella. Schizophr Res 24 (1,2): 247

    Article  Google Scholar 

  15. Brown AS, Cohen P, Greenwald S, Susser E (2000) Non-affective psychosis after prenatal exposure to rubella. Am J Psychiatry 157 (3): 438–443

    Article  PubMed  CAS  Google Scholar 

  16. Brown AS, Cohen P, Harkavy-Friedman J, Babulas V, Malaspina D, Gorman JM, Susser ES (2001) Bennett Research Award. Prenatal rubella, premorbid abnormalities, and adult schizophrenia. Biol Psychiatry 49 (6): 473–486

    Article  PubMed  CAS  Google Scholar 

  17. Buka SL, Tsuang MT, Lipsitt LP (1993) Pregnancy/delivery complications and psychiatric diagnosis. A prospective study. Arch Gen Psychiatry 50: 151–156

    Article  PubMed  CAS  Google Scholar 

  18. Cannon M, Cotter D, Sham PC, Larkin C, Murray RM, Coffey VP, O’Callaghan E (1996) Schizophrenia in an Irish sample following prenatal exposure to the 1957 influenza epidemic: a case-controlled, prospective follow-up study. Abstr Schizophr Res 11: 95

    Google Scholar 

  19. Cannon M, Jones P, Gilvarry C, Rifkin L, McKenzie K, Foerster A, Murray R (1997) Pre-morbid social functioning in schizophrenia and Bipolar disorder. Similarities and differences. Am J Psychiatry 154 (11): 1544–1550

    PubMed  CAS  Google Scholar 

  20. Cannon M, Jones P, Huttunen M, Tanskanen A, Huttunen T, Rabe-Hesketh S, Murray RM (1999) School performance in Finnish children and the latter development of schizophrenia: a population-based longitudinal study. Arch Gen Psychiatry 56: 457–463

    Article  PubMed  CAS  Google Scholar 

  21. Cannon M, Caspi A, Moffitt T, Harrington H-L, Taylor A, Murray RM, Poulton R (2001) Evidence for early, pan-developmental impairment specific to schizophreniform disorder. Results from a longitudinal birth cohort. Arch Gen Psychiatry 59 (5): 449–456

    Article  Google Scholar 

  22. Cannon-Spoor HE, Potkin SG, Wyatt RJ (1982) Measurement of premorbid adjustment in chronic schizophrenia. Schizophr Bulletin 8 (3): 470–484

    Article  CAS  Google Scholar 

  23. Castillo SM, Cabrera JS (1979) Estudio de las particulas semejantes a virus observadas en la esquizofrenia. Rev Hosp Psiquiatr Habana 10: 725–736

    Google Scholar 

  24. Castle D, Wessley S, Der G, Murray RM (1991) The incidence of operationally-defined schizophrenia in Camberwell 1965–84. Br J Psychiatry 159: 790–794

    Article  PubMed  CAS  Google Scholar 

  25. Chacon C, Monro M, Harper I (1975) Viral infection and psychiatric disorders. Acta Psychiatr Scand 51: 101–103

    Article  PubMed  CAS  Google Scholar 

  26. Chess S, Korn SJ, Fernandez PB (1971) Psychiatric Disorders of Children with Congenital Rubella. Butterworths, London

    Google Scholar 

  27. Coffey VP, Jessop WJE (1959) Maternal influenza and congenital deformities: a prospective study. Lancet ii: 935–938

    Google Scholar 

  28. Coffey VP, Jessop WJE (1963). Maternal influenza and congenital deformities. A follow-up study. Lancet is 748–751

    Google Scholar 

  29. Cooper SJ, King DJ (1987) Can psychiatric nurses `catch’ schizophrenia? Br J Psychiatr 151: 546–548

    Article  CAS  Google Scholar 

  30. Crow TJ, Done J (1986) Age of onset of schizophrenia in siblings: a test of contagion hypothesis. Psychiatr Res 18: 107–117

    Article  CAS  Google Scholar 

  31. Crow TJ, Done J (1992) Prenatal exposure to influenza does not cause schizophrenia. Br J Psychiatry 161: 390–393

    Article  PubMed  CAS  Google Scholar 

  32. Crow TJ, Done DJ, Johnstone EC (1991) Schizophrenia and influenza. Lancet 338: 116–117

    Article  Google Scholar 

  33. Crow TJ, Done DJ, Sacker A (1995) Childhood precursors of psychosis as clues to its evolutionary origins. Eur Arch Psychiatry & Clin Neurosci 245 (2): 61–69

    Article  CAS  Google Scholar 

  34. David AS, Cutting J (1994) (eds) The Neuropsychology of Schizophrenia. Lawrence Erlbaum, Hove

    Google Scholar 

  35. David AS, Malmberg A, Brandt L, Allebeck P, Lewis G (1997) IQ and risk for schizophrenia: a population-based cohort study. Psychol Medicine 27: 1311–1323

    Article  CAS  Google Scholar 

  36. Davidson M, Reichenberg A, Rabinowitz J, Weiser M, Kaplan Z, Mark M (1999) Behavioral and intellectual markers for schizophrenia in apparently healthy male adolescents. Am J Psychiatry 156 (9): 1328–1335

    PubMed  CAS  Google Scholar 

  37. Done DJ, Crow TJ, Johnstone EC, Sacker A (1994) Childhood antecedents of schizophrenia and affective illness: social adjustment at ages 7 and 11. Br Med J 309: 699–703

    Article  CAS  Google Scholar 

  38. Done J, Johnstone EC, Frith CD, Golding J, Shepard PM, Crow TJ (1991) Complications of pregnancy and delivery in relation to psychosis in adult life: data from the British Perinatal Mortality Survey. Br Med J 302: 1576–1580

    Article  CAS  Google Scholar 

  39. Erlenmeyer-Kimling L, Cornblatt B, Friedman D et al. (1982) Neurological, electro-physiological and attentional deviations in children at risk of schizophrenia. In: Henn FA, Nasrallah H (eds) Schizophrenia as a Brain Disease. OUP, New York, pp 61–98

    Google Scholar 

  40. Erlenmeyer-Kimling L, Folnegovic Z, Hrabak-Zerjavic V, Borcic B, Folnegovic-Smalc V, Susser E (1994) Schizophrenia and prenatal exposure to the 1957 A2 influenza epidemic in Croatia. Am J Psychiatry 151 (10): 1496–1498

    Google Scholar 

  41. Fine PEM, Adelstein AM, Snowman J, Clarkson JA, Evans SM (1985) Long term effects of exposure to viral infections in utero. Br Med J 290: 509–511

    Article  CAS  Google Scholar 

  42. Fish B (1977) Neurobiological antecedents of schizophrenia in children. Arch Gen Psychiatry 34: 1297–1313

    Article  PubMed  CAS  Google Scholar 

  43. Fish B, Marcus J, Hans SL, Auerbach JG, Perdue S (1992) Infants at risk for schizophrenia: sequelae of a genetic neurointegrative defect. Arch Gen Psychiatry 49: 221–235

    Article  PubMed  CAS  Google Scholar 

  44. Foerster A, Lewis SW, Owen MJ, Murray RM (1991) Pre-morbid adjustment and personality in psychosis. Effects of sex and diagnosis. Br J Psychiatry 158: 171–176

    Article  PubMed  CAS  Google Scholar 

  45. Geddes JR, Lawrie SM (1995) Obstetric events in schizophrenia: a meta-analysis. Br J Psychiatry 167: 786–793

    Article  PubMed  CAS  Google Scholar 

  46. Gervin M, Browne S, Lane A, Clarke M, Waddington JL, Larkin C, O’Callaghan E (1998) Spontaneous abnormal involuntary movements in first episode schizophrenia and schizophreniform disorder: baseline rate in a group of patients from an Irish catchment area. Am J Psychiatry 155: 1202–1206

    PubMed  CAS  Google Scholar 

  47. Gilvarry CM, Sham PC, Jones PB, Cannon M, Wright P, Lewis SW, Bebbington P, Toone BK, Murray RM (1996) Autoimmune diseases and psychosis: a case control family study. Schizophr Res 19: 33–40

    Article  PubMed  CAS  Google Scholar 

  48. Gittleman-Klein R, Klein DF (1969) Premorbid social adjustment and prognosis in schizophrenia. J Psych Research 7: 35–53

    Article  Google Scholar 

  49. Goodman R (1988) Obstetric complications and schizophrenia. Br J Psychiatry 153: 850

    Article  PubMed  CAS  Google Scholar 

  50. Green MF (1998) Schizophrenia from a Neurocognitive Perspective. Probing the Impenetrable Darkness. Allyn & Bacon, Needham Heights, MA

    Google Scholar 

  51. Hafner H, Riecher A, Maurer K, Loffler W (1989) How does gender influence age at first hospitalisation for schizophrenia? A transnational case register study. Psychol Med 19: 903–918.

    Article  PubMed  CAS  Google Scholar 

  52. Hafner H, Maurer K, Loffler W, Riecher-Rossler A (1993) The influence of age and sex on the onset and early course of schizophrenia. Br J Psychiatry 162: 80–86

    Article  PubMed  CAS  Google Scholar 

  53. Hare EH (1975) Season of birth in schizophrenia and neurosis. Am J Psychiatry 132: 1168–1171

    PubMed  CAS  Google Scholar 

  54. Hare EH (1976) The season of birth of siblings of psychiatric patients. Br J Psychiatry 129: 49–54

    Article  PubMed  CAS  Google Scholar 

  55. Hare EH, Price JS, Slater ETO (1974) Mental disorder and season of birth: a national sample compared with the general population. Br J Psychiatry 124: 81–86

    Article  PubMed  CAS  Google Scholar 

  56. Hunt H (1952) Testing for psychological deficit. In: Brower D, Abt LE (eds) Progress in Clinical Psychology. Vol I Ronald Press, New York

    Google Scholar 

  57. Hunt JMcV, Cofer C (1944) Psychological deficit. In: Hunt JMcV (ed) Personality and the Behavior Disorders. Ronald Press, New York.

    Google Scholar 

  58. Huttunen M, Niskanen P (1978) Prenatal loss of father and psychiatric disorders. Arch Gen Psychiatry 35: 427–431

    Article  Google Scholar 

  59. Isohanni M, Mäkikyrö T, Moring J, Rasanen P, Hakko H, Partanen U, Koiranen M, Jones PB (1997) A comparison of clinical and research DSM-III-R diagnoses of schizophrenia in a Finnish national birth cohort. Soc Psychiatry Psychiatric Epidemiol 32: 303–308

    Article  CAS  Google Scholar 

  60. Isohanni M, Jones PB, Kemppainen L, Croudace T, Isohanni I, Veijola J, Rasanen S, Wahlberg KE, Tienari P, Rantakallio P (2000) Childhood and adolescent predictors of schizophrenia in the Northern Finland 1966 birth cohort - a descriptive life-span model. Eur Arch Psychiatry Clin Neurosci 250 (6): 311–319

    Article  PubMed  CAS  Google Scholar 

  61. Isohanni M, Jones P B, Moilanen K, Rantakallio P, Veijola J, Oja H, Koiranen M, Jokelainen J, Croudace T, Jarvelin MR (2001) Early developmental milestones in adult schizophrenia and other psychoses. A 31-year follow-up of the North Finland 1966 birth cohort. Schizophr Res 52: 1–19

    Article  PubMed  CAS  Google Scholar 

  62. Jones PB (1999) Longitudinal approaches to the search for the causes of schizophrenia: past, present and future. In: Hafner H, Gattaz WF (eds) Search for the Causes of Schizophrenia, Vol. IV. Darmstadt: Steinkopff (Springer), Berlin, pp 91–119

    Google Scholar 

  63. Jones PB (1996) Childhood motor milestones and IQ prior to adult schizophrenia: results from a 43-year-old British birth cohort. Psychiatria Fennica 26: 63–80

    Google Scholar 

  64. Jones PB, Rodgers B, Murray RM, Marmot MG (1994) Child developmental risk factors for adult schizophrenia in the British 1946 birth cohort. Lancet 344: 1398–1402

    Article  PubMed  CAS  Google Scholar 

  65. Jones PB, Guth CW, Lewis SW, Murray RM (1994) Low intelligence and poor educational achievement precede early onset schizophrenic psychosis. In: David AS, Cutting J (eds) The Neuropsychology of Schizophrenia Lawrence Erlbaum, Hove, pp 131–144

    Google Scholar 

  66. Jones PB, Murray RM, Rodgers B (1995) Childhood risk factors for schizophrenia in a general population birth cohort at age 43 years. In: Mednick SA, Hollister JM (eds) Neural Development in Schizohrenia: Theory and Practice. Plenum Press, New York, pp 151–176

    Chapter  Google Scholar 

  67. Jones PB, Cannon M (1998) The new epidemiology of schizophrenia: common methods for genetics and environment. Psychiatric Clinics of North America 21 (1): 1–25

    Article  PubMed  CAS  Google Scholar 

  68. Jones PB, Done DJ (1997) From birth to onset: a developmental perspective of schizophrenia in two national birth cohorts. In: Keshavan MS, Murray RM (eds) Neurodevelopment and Adult Psychopathology. Chapter 9 CUP: Cambridge, pp 119–136

    Google Scholar 

  69. Jones PB, Rantakallio P, Hartikainen AL, Isohanni M, Sipila P (1998) Schizophrenia as a long-term outcome of pregnancy, delivery and perinatal complications: a 28-year follow-up of the 1966 North Finland general population birth cohort. Am J Psychiatry 155: 355–364

    PubMed  CAS  Google Scholar 

  70. Jones PB, Pang D, Piracha S, Fine PEM (1998) The long-term effects of viral infections in utero: a 35 year follow-up study. Presentation at the Stanley Foundation symposium on bipolar disorder. Royal Society, London, September 1998

    Google Scholar 

  71. Kendell RE, Kemp IW (1989) Maternal influenza in the etiology of schizophrenia. Arch Gen Psychiatry 46: 878–882

    Article  PubMed  CAS  Google Scholar 

  72. Kendell RE, Adams W (1991) Unexplained fluctuations in the risk for schizophrenia by month and year of birth. Br J Psychiatry 158: 758–763

    Article  PubMed  CAS  Google Scholar 

  73. Kendell RE, Mclnneny K, Juszczak E, Bain M (2000) Obstetric complications and schizophrenia. Two case-control studies based on structured obstetric records. Br J Psychiatry 176:516–522

    Article  PubMed  CAS  Google Scholar 

  74. Keshavan MS, Murray RM (eds) (1997) Neurodevelopment and Adult Psychopathology. CUP, Cambridge

    Google Scholar 

  75. Kraepelin E (1896) Dementia Praecox. Psychiatrie 5th Edition. pp 426–441. Barth: Leipzig. Translated in: Cutting J, Shepherd M (eds) The Clinical Roots of the Schizophrenia Concept (1987). CUP Cambridge, pp 13–24

    Google Scholar 

  76. Kuh D, Ben-Shlomo Y (eds) (1997) A Life-Course Approach to Chronic Disease Epidemiology. OUP, Oxford

    Google Scholar 

  77. Kunugi H, Nanko S, Takei N, Saito K, Hayashi N, Kazamatsuri H (1995) Schizophrenia following in utero exposure to the 1957 influenza epidemics in Japan. Am J Psychiatry 152: 450–452

    PubMed  CAS  Google Scholar 

  78. Lane A, Kinsella A, Murphy P, Byrne M, Keenan J, Colgan K, Cassidy B, Sheppard N, Horgan R, Waddington JL, Larkin C, O’Callaghan E (1997) The anthropometric assessment of dysmorphic features in schizophrenia as an index of its developmental origins. Psychol Med 27: 1155–1164

    Article  PubMed  CAS  Google Scholar 

  79. Lane EA, Albee GW (1963) Childhood intellectual development of adult schizophrenics. J Abnorm Soc Psychol 67: 186–189

    Article  PubMed  CAS  Google Scholar 

  80. Lewis MS, Griffin PA (1981) An explanation for the season of birth effect in schizophrenia and certain other diseases. Psychol Bull 89: 589–596

    Article  PubMed  CAS  Google Scholar 

  81. Lewis MS (1989) Age incidence and schizophrenia: Part 1. The season of birth controversy. Schizophr Bull 15: 59–73

    Article  PubMed  CAS  Google Scholar 

  82. Lewis SW, Owen MJ, Murray RM (1989) Obstetric complications and schizophrenia: methodology and mechanisms. In: Schulz SC, Tamminga CA (eds) Schizophrenia - A Scientific Focus. Oxford University Press, New York, pp 56–68

    Google Scholar 

  83. Lubin A, Gieseking CF, Williams HL (1962) Direct measurement of cognitive deficit in schizophrenia. J Consult Psychol 26: 139–143

    Article  PubMed  CAS  Google Scholar 

  84. Malaspina D, Harlap S, Fennig S, Heiman D, Nahon D, Feldman D, Susser ES (2001) Advancing paternal age and the risk of schizophrenia. Arch Gen Psychiatry 58 (4): 361–367

    Article  PubMed  CAS  Google Scholar 

  85. Malmberg A, Lewis G, David A, Allebeck P (1998) Premorbid adjustment and personality in people with schizophrenia. Br J Psychiatry 172: 308–313

    Article  PubMed  CAS  Google Scholar 

  86. Marmott M, Wadsworth MEJ (eds) (1997) Fetal and early childhood environment: longterm health implications. Br Med Bull 53 (1): 126–146

    Google Scholar 

  87. Mason CF (1956) Pre-illness intelligence of mental hospital patients. J Consult Psychol 20: 297–300

    Article  PubMed  CAS  Google Scholar 

  88. Mattock C, Marmot M, Stern G (1988) Could Parkinson’s disease follow intra-uterine influenza? a speculative hypothesis. J Neurol. Neurosurg Psychiatry 51: 753–756

    Article  PubMed  CAS  Google Scholar 

  89. McGrath J (1999) Hypothesis: is low prenatal vitamin D a risk-modifying factor for schizophrenia? Schizophr Res 40 (3): 173–177

    Article  PubMed  CAS  Google Scholar 

  90. McGrath J (2001) Does ‘imprinting’ with low prenatal vitamin D contribute to the risk of various adult disorders? Med Hypoth 56 (3): 367–371

    Article  CAS  Google Scholar 

  91. McGrath JJ, Pemberton MR, Welham JL, Murray RM (1994) Schizophrenia and the influenza epidemics of 1954, 1957 and 1959: a southern hemisphere study. Schizophr. Res 14: 1–8

    Article  PubMed  CAS  Google Scholar 

  92. McGrath JJ, Castle D, Murray RM (1995) How can we judge whether or not prenatal exposure to influenza causes schizophrenia. In: Mednick SA, Hollister JM (eds) Neural Development and Schizophrenia. Theory and Research. Plenum Press, New York

    Google Scholar 

  93. McIntosh ED, Menser MA (1992) A fifty-year follow-up of congenital rubella. Lancet 340: 414–415

    Article  PubMed  CAS  Google Scholar 

  94. Mednick SA, Machon RA, Huttunen MO, Bonett D (1988) Adult schizophrenia following prenatal exposure to an influenza epidemic. Arch Gen Psychiatry 45: 189–192

    Article  PubMed  CAS  Google Scholar 

  95. Mednick SA, Machon RA, Huttunen MO (1990) An update on the Helsinki influenza project. Letter to Editor. Arch Gen Psychiatry 47: 292

    PubMed  CAS  Google Scholar 

  96. Mednick SA, Huttunen MO, Machon RA (1994) Prenatal influenza infections and adult schizophrenia. Schizophr Bull 20: 263–267

    Article  PubMed  CAS  Google Scholar 

  97. Menninger KA (1926) Influenza and schizophrenia. Am J Psychiatry 5: 469–529

    Google Scholar 

  98. Mimmack ML, Ryan M, Baba H, Navarro-Ruiz J, Iritani S, Faull RLM, McKenna PJ, Jones PB, Arai H, Starkey M, Emson PC, Bahn S (2002) Gene expression analysis in schizophrenia: reproducible upregulation of several members of the apolipoprotein L family located in a high susceptibility locus for schizophrenia on chromosome 22. Proc Natl Acad Sci 99 (7): 4680–4685

    Article  PubMed  CAS  Google Scholar 

  99. Morgan V, Castle D, Page A, Fazio S, Gurrin L, Burton P, Montgomery P, Jablensky A (1997) Influenza epidemics and incidence of schizophrenia, affective disorders and mental retardation in Western Australia: no evidence of a major effect. Schizophr Res 26: 25–39

    Article  PubMed  CAS  Google Scholar 

  100. Murray RM, Jones PB, O’Callaghan E, Takei N, Sham PC (1992) Genes, Viruses and Neurodevelopmental Schizophrenia. J Psychiatric Res 26 (4): 225–235

    Article  CAS  Google Scholar 

  101. Myhrman A, Rantakallio P, Isohanni M, Jones PB, Partanen U (1996) Does unwantedness of a pregnancy predict schizophrenia? Br J Psychiatry 169: 637–640

    Article  PubMed  CAS  Google Scholar 

  102. Nelson KB, Ellenberg JH (1986) Antecedents of cerebral palsy: multivariate analysis of risk. New Eng J Med 315: 81–86

    Article  PubMed  CAS  Google Scholar 

  103. O’Callaghan E, Sham P, Takei N, Glover G, Murray RM (1991) Schizophrenia after prenatal exposure to 1957 A2 influenza epidemic. Lancet 337: 1248–1250

    Article  PubMed  Google Scholar 

  104. Parker G (1978) Schizophrenia and season of birth: further southern hemisphere studies. Aus NZ J Psychiatr 12: 65–67

    Article  CAS  Google Scholar 

  105. Parker G, Neilson M (1976) Mental disorder and season of birth - a southern hemisphere study. Br J Psychiatry 129: 355–361

    Article  PubMed  CAS  Google Scholar 

  106. Pasamanick B, Rodgers ME, Lilienfield AM (1956) Pregnancy experience and behaviour disorder in children. Am J Psychiatry 112: 613–618

    PubMed  CAS  Google Scholar 

  107. Pidgeon DA (1964) Tests used in the 1954 and 1957 surveys. In: Douglas JWB (ed) The Home and the School. MacGibbon & Kee, London, pp 129–132

    Google Scholar 

  108. Pidgeon DA (1968) Appendix: details of the fifteen year tests. In: Douglas JWB, Ross JM, Simpson HR (eds) All Our Futures. Peter Davies, London, pp 194–197

    Google Scholar 

  109. Poulton R, Caspi A, Moffitt TE, Cannon M, Murray R, Harrington H (2000) Children’s self-reported psychotic symptoms and adult schizophreniform disorder: a 15-year longitudinal study. Arch Gen Psychiatry 57 (11): 1053–1058

    Article  PubMed  CAS  Google Scholar 

  110. Price JS, Hare EH (1969) Birth Order Studies: some sources of bias. Br J Psychiatry 115: 633–646

    Article  PubMed  CAS  Google Scholar 

  111. Rantakallio P (1969) Groups at risk in low birth weight infants and perinatal mortality. Acta Paediatrica Scandinavia Supplement 193: 1–71

    Google Scholar 

  112. Rantakallio P, von Wendt L (1986) A prospective comparative study of the etiology of cerebral palsy and epilepsy in a one-year birth cohort from Northern Finland. Acta Paediatr Scand 75: 586–592

    Article  PubMed  CAS  Google Scholar 

  113. Rantakallio P, Jones P, Moring J, Von Wendt L (1997) Association between central nervous system infections during childhood and adult onset schizophrenia and other psychoses: a 28-year follow-up. Int J Epidemiol 26: 837–843

    Article  PubMed  CAS  Google Scholar 

  114. Rappaport SR, Webb WB (1950) An attempt to study intellectual deterioration by pre-morbid testing. J Consult Psychol 14: 95–98

    Article  Google Scholar 

  115. Robins LN (1966) Deviant Children Grown Up. A Sociological and Psychiatric Study of Sociopathic Personality. Williams and Wilkins, Baltimore

    Google Scholar 

  116. Robins LN, Rutter M (eds) (1990) Straight and Devious Pathways from Childhood to Adulthood. Cambridge University Press, Cambridge 1991, c1990

    Google Scholar 

  117. Rothman KJ (1976) Causes. Am J Epidemiol 104: 587–592

    PubMed  CAS  Google Scholar 

  118. Rothman KJ (1977) Causes and risks. In: Clark MA (ed) Pulmonary Disease: Defense Mechanisms and Populations at Risk. Tobacco and Health Research Institute, Lexington, KY

    Google Scholar 

  119. Rothman KJ (ed) (1988) Causal Inference. Epidemiology Resources, Chestnut Hill, MA

    Google Scholar 

  120. Russell AJ, Munro JC, Jones PB, Hemsley DR, Murray RM (1997) Schizophrenia and the myth of intellectual decline. Am J Psychiatry 154 (5): 635–639

    PubMed  CAS  Google Scholar 

  121. Sacker A, Done DJ, Crow TJ, Golding J (1995) Antecedents of schizophrenia and affective illness. Obstetric complications. Br J Psychiatry 166 (6): 734–741

    Article  PubMed  CAS  Google Scholar 

  122. Sadowski H, Ugarte B, Kolvin I, Kaplan C, Barnes J (1999) Early life family disadvantages and major depression in adulthood. Br J Psychiatry 174: 112–120

    Article  PubMed  CAS  Google Scholar 

  123. Selten JPCJ, Slaets JPJ (1994) Second-trimester exposure to 1957 A2 influenza epidemic is not a risk factor for schizophrenia. Abstr Schizophr Res 11: 95

    Google Scholar 

  124. Sham PC, O’Callaghan E, Takei N, Murray GK, Hare EH, Murray RM (1992) Schizophrenia following pre-natal exposure to influenza epidemics between 1939 and 1960. Br J Psychiatry 160: 461–466

    Article  PubMed  CAS  Google Scholar 

  125. Schur E, Hare EH (1983) Age prevalence and the season of birth effect in schizophrenia: a response to Lewis and Griffin. Psychol Bull 93: 373–377

    Article  Google Scholar 

  126. Stevens JR, Hallick LM (1992) Viruses and schizophrenia. In: Specter S, Bendinelli M, Friedman H (eds) Neuropathogenic Viruses and Immunity. Plenum, New York, pp 27–53

    Google Scholar 

  127. Stevens JR, Albrecht P, Godfrey L, Krauthammer E (1983) Viral antigen in the brain of schizophrenic patients? In: Morozov PV (ed) Research on the Viral Hypothesis of Mental Disorders. Karger, Basel, pp 76–96

    Google Scholar 

  128. Suddath RL, Christison GW, Torrey EF, Casanova MF, Weinberger DR (1990) Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia. New Eng J Med 322: 789–794

    Article  PubMed  CAS  Google Scholar 

  129. Susser E, Lin SP (1992) Schizophrenia after prenatal exposure to the Dutch hunger winter of 1944–1945. Arch Gen Psychiatry 49: 983–988

    Article  PubMed  CAS  Google Scholar 

  130. Susser E, Lin SP (1994) Schizophrenia after prenatal exposure to the Dutch hunger winter of 1944–1945. Arch Gen Psychiatry 51: 333–334

    Article  Google Scholar 

  131. Susser ES, Lin SP, Brown AS, Lumey LH, Erlenmeyer-Kimling L (1994) No relation between risk of schizophrenia and prenatal exposure to influenza in Holland. Am J Psychiatry 151: 922–924

    PubMed  CAS  Google Scholar 

  132. Susser E, Neugebauer R, Hoek HW, Brown AS, Lin S, Labovitz D, Gorman JM (1996) Schizophrenia after prenatal famine. Arch Gen Psychiatry 53: 25–31

    Article  PubMed  CAS  Google Scholar 

  133. Susser E, Brown AS, Gorman JM (eds) (1999) Prenatal Exposures in Schizophrenia. American Psychiatric Association Press: Washington DC

    Google Scholar 

  134. Takei N, Sham P, O’Callaghan E, Murray GK, Glover G, Murray RM (1994) Prenatal exposure to influenza and the development of schizophrenia: is the effect confined to females? Am J Psychiatry 151: 117–119

    PubMed  CAS  Google Scholar 

  135. Tarrant J, Jones PB (1999) Precursors to schizophrenia: do biological markers for schizophrenia have specificity? Can J Psychiatry 44: 176–195

    Google Scholar 

  136. Tienari P, Sorri A, Lahti I, Naarala M, Wahlberg K, Moring J, Pohjola J, Wynne LC (1987) Genetic and psychosocial factors in schizophrenia: The Finnish Adoptive Family Study. Schizophr Bull 13 (3): 477–484

    Article  PubMed  CAS  Google Scholar 

  137. Tienari P, Wynne LC, Moring J, Laksy K, Nieminen P, Sorri A, Lahti I, Wahlberg K-E, Naarala M, Kurki-Suonio K, Saarento O, Koistinen P, Tarvainen T, Hakko H, Miettunen J (2000) Finnish adoptive family study: sample selection and adoptee DSM-III-R diagnoses. Acta Psychiatr Scand 101 (6): 433–443

    Article  PubMed  CAS  Google Scholar 

  138. Torrey EF, Peterson MR (1973) Slow and latent viruses in schizophrenia. Lancet 2: 22–24

    Article  PubMed  CAS  Google Scholar 

  139. Torrey EF, Bowler AE (1990) The seasonality of schizophrenic births: a reply to Marc S Lewis. Schizophr Bull 16 (1): 1–3

    Article  PubMed  CAS  Google Scholar 

  140. Torrey EF, Bowler A (1990) Geographical distribution of insanity in America: evidence for an urban factor. Schizophr Bull 16: 591–604

    Article  PubMed  CAS  Google Scholar 

  141. Torrey EF, Bowler AE, Rawlings R, Terrazas A (1993) Seasonality of schizophrenia and stillbirths. Schizophr Bull 19: 557–562

    Article  PubMed  CAS  Google Scholar 

  142. Tramer T (1929) Uber die biologische Bedeutung des Geburtesmonnates fur die Psychogerkrankung. Schweizer. Archiv fur Neurologie and Psychiatrie 24: 17–24

    Google Scholar 

  143. van Os J, Jones PB, Lewis G, Wadsworth M, Murray R (1997) Developmental precursors of affective illness in a general population birth cohort. Arch Gen Psychiatry 54: 625–631

    Article  PubMed  Google Scholar 

  144. van Os J, Selten J-P (1998) Prenatal exposure to maternal stress and later schizophrenia: the May 1940 invasion of the Netherlands. Br J Psychiatry 172: 324–326

    Article  PubMed  Google Scholar 

  145. Wadsworth MEJ (1987) Follow-up of the first national birth cohort: findings from the Medical Research Council National Survey of Health and Development. Paediatric and Perinatal Epidemiology 1: 95–117

    Article  PubMed  CAS  Google Scholar 

  146. Wadsworth MEJ (1991) The Imprint of Time. Childhood history and adult life. Clarendon Press, Oxford

    Google Scholar 

  147. Walker E, Lewine RJ (1990) Prediction of adult-onset schizophrenia from childhood home movies of the patients. Am J Psychiatry 147: 1052–1056

    PubMed  CAS  Google Scholar 

  148. Walker EF, Grimes KE, Davis DM, Smith AJ (1993) Childhood precursors of schizophrenia: facial expressions of emotion. Am J Psychiatry 150: 1654–1660

    PubMed  CAS  Google Scholar 

  149. Watson CG, Kucala T, Angulski G, Brunn C (1982) Season of birth and schizophrenia: a response to the Lewis and Griffin critique. J Abnorm Psychol 91: 120–125

    Article  PubMed  CAS  Google Scholar 

  150. Watt NF (1978) Patterns of childhood social development in adult schizophrenics. Arch Gen Psychiatry 35: 160–165

    Article  PubMed  CAS  Google Scholar 

  151. Watt N, Lubensky A (1976) Childhood roots of schizophrenia. J Consult Clin Psychol 44: 363–375

    Article  PubMed  CAS  Google Scholar 

  152. Weinberger DR (1995) From neuropathology to neurodevelopment. Lancet 346: 552–557

    Article  PubMed  CAS  Google Scholar 

  153. Weinberger DR, Berman KF Suddath R, Torrey EF (1992) Evidence for a prefrontal-limbic network in schizophrenia: a magnetic resonance and regional cerebral blood flow study of discordant monozygotic twins. Am J Psychiatry 149: 890–897

    PubMed  CAS  Google Scholar 

  154. Wright P, Sham PC, Gilvarry C, Jones PB, Cannon M, Sharma T, Murray RM (1996) Autoimmune disorders in the pedigrees of schizophrenic and control subjects. Schizophr Res 20: 261–267

    Article  PubMed  CAS  Google Scholar 

  155. Yolken RH, Torrey EF (1995) Viruses, schizophrenia and bipolar disorder. Clin Microbiol Rev 8: 131–145

    PubMed  CAS  Google Scholar 

  156. Zornberg GL, Buka SL, Tsuang MT (2000) Hypoxic-ischemia-related fetal/neonatal complications and risk of schizophrenic and other nonaffective psychoses: a 19-year longitudinal study. Am J Psychiatry 157 (2): 196–202

    Article  CAS  Google Scholar 

  157. Zornberg GL, Buka SL, Tsuang MT (2000) The problem of obstetrical complications and schizophrenia. Schizophr Bull 26 (2) 249–256

    Article  PubMed  CAS  Google Scholar 

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  1. Department of Psychiatry, University of Cambridge, UK

    P. B. Jones

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  1. Schizophrenia Research Unit, Central Institute of Mental Health, J 5, Mannheim, 68159, Germany

    Heinz Häfner

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Jones, P.B. (2002). Risk factors for schizophrenia in childhood and youth. In: Häfner, H. (eds) Risk and Protective Factors in Schizophrenia. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-57516-7_13

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  • DOI: https://doi.org/10.1007/978-3-642-57516-7_13

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-642-63282-2

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