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Presynaptic Neuronal Nicotinic Receptors: Pharmacology, Heterogeneity, and Cellular Mechanisms

  • Chapter
Neuronal Nicotinic Receptors

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 144))

Abstract

Despite the widespread distribution and extensive heterogeneity of nicotinic receptor (nAChR) subunits in the nervous system, the physiological significance of nAChRs remains obscure. The paucity of evidence of nicotinic synaptic transmission in the CNS prompted speculation that the purpose of nAChRs is to modulate, rather than mediate, neurotransmission (ROLE and BERG 1996). The presynaptic localisation of nAChRs is compatible with such a role (WONNACOTT 1997). This chapter aims to summarise the evidence for presynaptic nAChRs and to consider the cellular mechanisms relating to their activation and the implications for synaptic functioning.

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  1. S. Kaiser
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  2. L. Soliakov
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  3. S. Wonnacott
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  1. Università degli Studi di Milano Dipartimento di Farmacologia, Chemoterapia e Tossicologia Medica “Emilio Trabucchi”, Via Vanvitelli, 32, 20129, Milano, Italy

    Francesco Clementi , Diego Fornasari  & Cecilia Gotti ,  & 

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Kaiser, S., Soliakov, L., Wonnacott, S. (2000). Presynaptic Neuronal Nicotinic Receptors: Pharmacology, Heterogeneity, and Cellular Mechanisms. In: Clementi, F., Fornasari, D., Gotti, C. (eds) Neuronal Nicotinic Receptors. Handbook of Experimental Pharmacology, vol 144. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57079-7_8

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