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Nicotinic Acetylcholine Receptors in Ganglionic Transmission

  • Chapter
Neuronal Nicotinic Receptors

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 144))

Abstract

For nearly a century autonomic ganglia have been strategic preparations for elucidating the principles of nicotinic transmission and the nature of nicotinic acetylcholine receptors (nAChRs) in the nervous system. The first evidence for neurotransmitters anywhere was the demonstration by LOEWI (1921) that a diffusible substance, later shown to be acetylcholine (ACh), was necessary to mediate the effects of parasympathetic innervation to the heart. Early biochemical studies examining ACh synthesis and release first made use of cat superior cervical ganglia (BIRKS and MACINTOSH 1961). Classical electrophysiological mapping of nicotinic ACh responses from frog autonomic ganglia by Kuffler and his colleagues first showed the clustering of functional postsynaptic nAChRs near presynaptic boutons (DENNIS et al. 1971; HARRIS et al. 1971).

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  1. D. K. Berg
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  2. R. D. Shoop
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  3. K. T. Chang
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  4. J. Cuevas
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  1. Università degli Studi di Milano Dipartimento di Farmacologia, Chemoterapia e Tossicologia Medica “Emilio Trabucchi”, Via Vanvitelli, 32, 20129, Milano, Italy

    Francesco Clementi , Diego Fornasari  & Cecilia Gotti ,  & 

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Berg, D.K., Shoop, R.D., Chang, K.T., Cuevas, J. (2000). Nicotinic Acetylcholine Receptors in Ganglionic Transmission. In: Clementi, F., Fornasari, D., Gotti, C. (eds) Neuronal Nicotinic Receptors. Handbook of Experimental Pharmacology, vol 144. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57079-7_10

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