Abstract
Nitric oxide (NO) research in immunology started in 1985 when Stuehr and Marietta discovered that mouse macrophages produce nitrite and nitrate in a L-arginine-dependent manner after stimulation by lipopolysaccharide (LPS) and/or cytokines in vitro (STUEHR and MARLETTA 1985). Although the biochemistry of the underlying pathway was not known at that time, the critical role of inflammatory stimuli for its induction soon led immunologists, cancer researchers, and infectious-diseases specialists to search for functions of the newly discovered macrophage metabolites. In 1987, the Schistosoma mansoni schistosomula were the first parasites shown to be destroyed by mammalian macrophages only in the presence of L-arginine (MALKIN et al. 1987). The same was found to be true for the killing of some tumor cells (HIBBS et al. 1987).
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Bogdan, C. (2000). The Function of Nitric Oxide in the Immune System. In: Mayer, B. (eds) Nitric Oxide. Handbook of Experimental Pharmacology, vol 143. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57077-3_19
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