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Apoptosis of Nerve Cells

  • Chapter
Apoptosis and Its Modulation by Drugs

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 142))

Abstract

One of the major challenges facing neuroscientists is to understand the molecular basis of nerve cell death in the brain and spinal cord. This information will provide the basis for a rationale drug design strategy to treat acute (e.g., stroke, traumatic brain injury, status epilepticus, perinatal asphyxia) and chronic (e.g., Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis) neurodegenerative disorders. For many years it was thought that nerve cells die in these diseases by a passive necrotic lysistype mechanism. More recently, data from a number of sources including human brain material, and in vitro and in vivo models, have suggested that degenerative nerve cell death might be caused by an active apoptotic mechanism (reviewed in Dragunow et al. 1998).

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Authors
  1. A.-M. Woodgate
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  2. M. Dragunow
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Editors and Affiliations

  1. Department of Pathology Toronto Hospital, General Division, University of Toronto, 200 Elizabeth Street, Toronto, Ontario, Canada, M5G 2C4

    Ross G. Cameron M.D., Ph.D.

  2. Banting Institute Department of Clinical Biochemistry, University of Toronto, Toronto, Ontario, Canada, M5G 2C4

    George Feuer Ph.D., C. Med. Sci.

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Woodgate, AM., Dragunow, M. (2000). Apoptosis of Nerve Cells. In: Cameron, R.G., Feuer, G. (eds) Apoptosis and Its Modulation by Drugs. Handbook of Experimental Pharmacology, vol 142. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57075-9_8

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  • DOI: https://doi.org/10.1007/978-3-642-57075-9_8

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