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The History and Biology of Marek’s Disease Virus

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Marek’s Disease

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 255))

Abstract

Marek’s Disease (MD) was the term chosen in 1960 for a common lymphoproliferative disease principally of the domestic chicken (Gallus domesticus), which is now known to be caused by a cell-associated alpha herpesvirus. The lymphoproliferative process in MD can involve most organs and tissues including peripheral nerves. The most commonly affected organs and tissues are peripheral nerves, iris,gonads, spleen, heart, lung, liver and muscle. Cytolytic changes and atherosclerosis can be a manifestation of MD virus (MDV) infection as can a clinical syndrome described as transient paralysis.

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  1. Willows, London Road, St. Ives, PE27 5ES, UK

    P. M. Biggs

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  1. Department of Tumor Virology, Medical Research Institute, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, 113-8510, Tokyo, Japan

    Kanji Hirai

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Biggs, P.M. (2001). The History and Biology of Marek’s Disease Virus. In: Hirai, K. (eds) Marek’s Disease. Current Topics in Microbiology and Immunology, vol 255. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56863-3_1

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  • DOI: https://doi.org/10.1007/978-3-642-56863-3_1

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