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Myelin Molecules Limiting Nervous System Plasticity

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Guidance Cues in the Developing Brain

Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 32))

During development, nerve growth cones are guided by a balance of positive and negative cues that ensure robust axon outgrowth and fine-tuned control of direction and trajectory (Stoeckli and Landmesser 1998). In contrast to the embryonic environment, the injured adult central nervous system (CNS) in mammals is overwhelmingly inhibitory for axon outgrowth, severely limiting nerve regeneration (Fry 2001). The inability of axons to regrow after CNS injury has profound medical consequences. This is most evident in the lack of recovery from spinal cord injuries, which result in life-long loss of function for millions of people worldwide (Geisler et al. 2001;,Sekhon and Fehlings 2001). The pathology of brain trauma, stroke, and progressive multiple sclerosis are also negatively impacted by limitations on axon outgrowth in the CNS. The discovery of the molecular mechanisms that render the CNS such an inhospitable environment for nerve regeneration may provide new approaches to enhance recovery of nerve damage after injury or disease (Kwon and Tetzlaff 2001).

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  1. Departments of Pharmacology and Neuroscience, The Johns Hopkins School of Medicine, 725 N. Wolfe Street, Baltimore, Maryland, 21205, USA

    R. L. Schnaar

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  1. Croatian Institute for Brain Research School of Medicine, University of Zagreb, Šalata 12, Zagreb, 10000, Croatia

    Ivica Kostović

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Schnaar, R.L. (2003). Myelin Molecules Limiting Nervous System Plasticity. In: Kostović, I. (eds) Guidance Cues in the Developing Brain. Progress in Molecular and Subcellular Biology, vol 32. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55557-2_6

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  • DOI: https://doi.org/10.1007/978-3-642-55557-2_6

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