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Biotechnological Potential of Marine Microbes

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Springer Handbook of Marine Biotechnology

Part of the book series: Springer Handbooks ((SHB))

Abstract

The world’s oceans, from the coasts to the abysses, harbor an incredible level of microbial diversity. This marine microbial biosphere is an enormous, untapped resource of biotechnological interest. This chapter reviews the potential of marine microbes in biotechnology. The biotechnological potential is considerable, ranging from the synthesis of bioactive molecules to the production of biofuels, cosmeceuticals, nutraceuticals, and biopolymers; from the engineering of marine microbes for biomedical purposes to the degradation of pollutants, and the use of microbial biosensors as sentinels for environmental quality. Marine viruses have great biotechnological potential, yet the exploration of the marine virome, and the associated gene and protein pool, is only beginning. Marine archaea have so far been exploited for the isolation of enzymes, yet many biotechnological exploitations can be foreseen. Bacteria and microbial eukaryotes, especially fungi and photosynthetic protists, provide an important contribution to biotechnology; the combination of omics-driven technologies and improved cultivation techniques is widening the knowledge on their biological diversity, paving the way for new biotechnological exploitations. The exploration of the marine microbial biosphere, and its extraordinary genetic and physiological diversity, will undoubtedly continue to offer chances for the development of new and sustainable blue biotechnologies, helping to solve important societal challenges of the twenty-first century.

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Abbreviations

AIDS:

acquired immunodeficiency syndrome

Ara-A:

vidarabine

Ara-C:

arebinosyl cytosine

DNA:

deoxyribonucleic acid

HIV:

human immunodeficiency virus

PHA:

polyhydroxyalkanoate

Pfu DNA:

thermostable DNA polymerase named after the thermophilic bacterium Pyrococcus furiosus

SEM:

scanning electron microscopy

Taq  DNA:

thermostable DNA polymerase named after the thermophilic bacterium Thermus aquaticus

References

  1. L. Zinger, L.A. Amaral-Zettler, J.A. Fuhrman, M.C. Horner-Devine, S.M. Huse, D.B.M. Welch, J.B.H. Martiny, M. Sogin, A. Boetius, A. Ramette: Global patterns of bacterial Beta-diversity in seafloor and seawater ecosystems, PLoS ONE 6(9), e24570 (2011)

    Article  CAS  Google Scholar 

  2. R. Stocker: Marine microbes see a sea of gradients, Science 338, 628–633 (2012)

    Article  CAS  Google Scholar 

  3. J.B.H. Martiny, B.J.M. Bohannan, J.H. Brown, R.K. Colwell, J.A. Fuhrman, J.L. Green, M.C. Horner-Devine, M. Kane, J.A. Krumins, C.R. Kuske, P.J. Morin, S. Naeem, L. Øvreås, A.-L. Reysenbach, V.H. Smith, J.T. Staley: Microbial biogeography: Putting microorganisms on the map, Nat. Rev. Microbiol. 4, 102–112 (2006)

    Article  CAS  Google Scholar 

  4. F.O. Glöckner, I. Joint: Marine microbial genomics in Europe: current status and perspectives, Microb. Biotechnology 3, 523–530 (2010)

    Article  Google Scholar 

  5. S. Giovannoni, U. Stingl: The importance of culturing bacterioplankton in the `omics' age, Nature 5, 820–826 (2007)

    CAS  Google Scholar 

  6. I. Joint, M. Mühling, J. Querellou: Culturing marine bacteria – an essential prerequisite for biodiscovery, Microb. Biotechnology 3, 564–575 (2010)

    Article  CAS  Google Scholar 

  7. S.J. Giovannoni, U. Stingl: Molecular diversity and ecology of microbial plankton, Nature 437, 343–348 (2005)

    Article  CAS  Google Scholar 

  8. M.L. Sogin, H.G. Morrison, J.A. Huber, M.D. Welch, S.M. Huse, P.R. Neal, J.M. Arrieta, G.J. Herndl: Microbial diversity in the deep sea and the underexplored “rare biosphere”, Proc. Natl. Acad. Sci. USA 103, 12115–12120 (2006)

    Article  CAS  Google Scholar 

  9. L. Zinger, A. Gobet, T. Pommier: Two decades of describing the unseen majority of aquatic microbial diversity, Mol. Ecol. 21, 1878–1896 (2012)

    Article  Google Scholar 

  10. W.J. Sul, T.A. Oliver, H.W. Ducklow, L.A. Amaral-Zettler, M.L. Sogin: Marine bacteria exhibit a bipolar distribution, Proc. Natl. Acad. Sci. USA 110, 2342–2347 (2013)

    Article  CAS  Google Scholar 

  11. Convention on Biological Diversity: http://www.cbd.int/convention/text/

  12. E. Rosenberg: Biotechnology and applied microbiology. In: The Prokaryotes – Prokaryotic Biology and Symbiotic Associations, ed. by E. Rosenberg, E.F. DeLong, E. Stackebrandt, S. Lory, F. Thompson (Springer-Verlag, Berlin Heidelberg 2013) pp. 315–328

    Google Scholar 

  13. R.H. Wijffels: Potential of sponges and microalgae for marine biotechnology, Trends Biotechnol. 26, 26–31 (2008)

    Article  CAS  Google Scholar 

  14. C.R. Woese: Bacterial evolution, Microbiol. Reviews 51, 221–271 (1987)

    CAS  Google Scholar 

  15. R. Massana, C. Pedrós-Alió: Unveiling new microbial eukaryotes in the surface ocean, Curr. Opin. Microbiol. 11, 213–218 (2008)

    Article  Google Scholar 

  16. K.B. Heidelberg, J.A. Gilbert, I. Joint: Marine genomics: at the interface of marine microbial ecology and biodiscovery, Microb. Biotechnology 3, 531–543 (2010)

    Article  CAS  Google Scholar 

  17. J.F. Imhoff, A. Labes, J. Wiese: Bio–mining the microbial treasures of the ocean: new natural products, Biotechnology Adv. 29, 468–482 (2011)

    Article  CAS  Google Scholar 

  18. G. Schwartsmann, A. da Brondani Rocha, R.G.S. Berlinck, J. Jimeno: Marine organisms as a source of new anticancer agents, The Lancet Oncol. 2, 221–225 (2001)

    Article  CAS  Google Scholar 

  19. P. Proksch, R.A. Edrada, R. Ebel: Drugs from the seas–current status and microbiological implications, Appl. Microbiol. Biotechnol. 59, 125–134 (2002)

    Article  CAS  Google Scholar 

  20. D. Sipkema, M.C.R. Franssen, R. Osinga, J. Tramper, R.H. Wijffels: Marine sponges as pharmacy, Mar. Biotechnology 7, 142–162 (2005)

    Article  CAS  Google Scholar 

  21. J.W. Blunt, B.R. Copp, W.P. Hu, M.H.G. Munro, P.T. Northcote, M.R. Prinsep: Marine natural products, Nat. Prod. Rep. 24, 31–86 (2007)

    Article  CAS  Google Scholar 

  22. D. Leary, M. Vierros, G. Hamon, S. Arico, C. Monagle: Marine genetic resources: a review of scientific and commercial interest, Mar. Policy 33, 183–194 (2009)

    Article  Google Scholar 

  23. D.G. Nagle, Y.D. Zhou, F.D. Mora, K.A. Mohammed, Y.P. Kim: Mechanism targeted discovery of antitumour marine natural products, Curr. Med. Chem. 11, 1725–1756 (2004)

    Article  CAS  Google Scholar 

  24. T.F. Molinski, D.S. Dalisay, S.L. Lievens, J.P. Saludes: Drug development from marine natural products, Nat. Rev. Drug. Discov. 8, 69–85 (2009)

    Article  CAS  Google Scholar 

  25. K.J. Schippers, D. Sipkema, R. Osinga, H. Smidt, S.A. Pomponi, D.E. Martens, R.H. Wijffels: Cultivation of sponges, sponge cells and symbionts: achievements and future prospects, Adv. Mar. Biol. 62, 273–337 (2012)

    Article  Google Scholar 

  26. J.B. Corliss, J. Dymond, L.I. Gordon, J.M. Edmond, R.P. von Herzen, R.D. Ballard, K. Green, D. Williams, A. Bainbridge, K. Crane, T.H. van Ande: Submarine thermal springs on the Galapagos Rift, Science 203, 1073–1083 (1979)

    Article  CAS  Google Scholar 

  27. P.W.J.J. Van der Wielen, H. Bolhuis, S. Borin, D. Daffonchio, C. Corselli, L. Giuliano, G. D'Auria, G.J. de Lange, A. Huebner, S.P. Varnavas, J. Thomson, C. Tamburini, D. Marty, T.J. McGenity, K.N. Timmis, BioDeep Scientific Party: The enigma of prokaryotic life in deep hypersaline anoxic basins, Science 307, 121–123 (2005)

    Article  CAS  Google Scholar 

  28. B.B. Jörgensen, A. Boetius: Feast and famine – microbial life in the deep-sea bed, Nature 5, 770–781 (2007)

    Google Scholar 

  29. J. Kennedy, B. Flemer, S.A. Jackson, D.P.H. Lejon, J.P. Morrissey, F. O'Gara, A.D.W. Dobson: Marine metagenomics: new tools for the study and exploitation of marine microbial metabolism, Mar. Drugs 8, 608–628 (2010)

    Article  CAS  Google Scholar 

  30. A. Dufresne, L. Garczarek, F. Partensky: Accelerated evolution associated with genome reduction in a free-living prokaryote, Genome Biol. 6, R14 (2005)

    Article  Google Scholar 

  31. S.J. Giovannoni, H.J. Tripp, S. Givan, M. Podar, K.L. Vergin, D. Baptista, L. Bibbs, J. Eads, T.H. Richardson, M. Noordewier, M.S. Rappe, J.M. Short, J.C. Carrington, E.J. Mathur: Genome streamlining in a cosmopolitan oceanic bacterium, Science 309, 1242–1245 (2005)

    Article  CAS  Google Scholar 

  32. A. Debbab, A.H. Aly, W.H. Lin, P. Proksch: Bioactive compounds from marine bacteria and fungi, Microb. Biotechnology 3, 544–563 (2010)

    Article  CAS  Google Scholar 

  33. M.G. Weinbauer: Ecology of prokaryotic viruses, FEMS Microbiol. Reviews 28, 127–181 (2004)

    Article  CAS  Google Scholar 

  34. C.A. Suttle: Marine viruses – major players in the global ecosystem, Nat. Rev. Microbiol. 5, 801–812 (2007)

    Article  CAS  Google Scholar 

  35. F. Azam, A.Z. Worden: Microbes, molecules, and marine ecosystems, Science 303, 1622–1624 (2004)

    Article  CAS  Google Scholar 

  36. F. Rohwer, R. Vega Thurber: Viruses manipulate the marine environment, Nature 459, 207–212 (2009)

    Article  CAS  Google Scholar 

  37. H. Brussow, R.W. Hendrix: Phage genomics: small is beautiful, Cell 108, 13–16 (2002)

    Article  CAS  Google Scholar 

  38. R. Danovaro, A. Dell'Anno, C. Corinaldesi, M. Magagnini, R. Noble, C. Tamburini, M. Weinbauer: Major viral impact on the functioning of benthic deep-sea ecosystems, Nature 454, 1084–1088 (2008)

    Article  CAS  Google Scholar 

  39. S.J. Williamson, D.B. Rusch, S. Yooseph, A.L. Halpern, K.B. Heidelberg, J.I. Glass, C. Andrews-Pfannkoch, D. Fadrosh, C.S. Miller, G. Sutton, M. Frazier, C. Venter: The Sorcerer II Global Ocean Sampling expedition: Metagenomic characterization of viruses within aquatic microbial samples, PLoS ONE 3(1), e1456 (2008)

    Article  CAS  Google Scholar 

  40. B. Levin, J. Bull: Phage therapy revisited: the population biology of a bacterial infection and its treatment with bacteriophage and antibiotics, Am. Naturalised 147, 881–898 (1996)

    Article  Google Scholar 

  41. T.P. Hughes, A.H. Baird, D.R. Bellwood, M. Card, S.R. Connolly, C. Folke, R. Grosberg, O. Hoegh-Guldberg, J.B.C. Jackson, J. Kleypas, J.M. Lough, P. Marshall, M. Nyström, S.R. Palumbi, J.M. Pandolfi, B. Rosen, J. Roughgarden: Climate change, human impacts, and the resilience of coral reefs, Science 5635, 929–933 (2003)

    Article  CAS  Google Scholar 

  42. R. Efrony, Y. Loya, E. Bacharach, E. Rosenberg: Phage therapy of coral disease, Coral Reefs 26, 7–13 (2007)

    Article  Google Scholar 

  43. Y. Cohen, F.J. Pollock, E. Rosenberg, D.G. Bourne: Phage therapy treatment of the coral pathogen Vibrio coralliilyticus, Microbiol. Open 2, 64–74 (2013)

    Article  CAS  Google Scholar 

  44. M. Onji, S. Nakano, S. Suzuki: Virus-like particles suppress growth of the red-tide-forming marine dinoflagellate Gymnodinium mikimotoi, Mar. Biotechnology 5, 435–442 (2003)

    Article  CAS  Google Scholar 

  45. E.F. DeLong: Archaea in coastal marine environments, Proc. Natl. Acad. Sci. USA 89, 5685–5689 (1992)

    Article  CAS  Google Scholar 

  46. E.F. DeLong: Everything in moderation: Archaea as “nonextremophiles”, Curr. Opin. Genet. Dev. 8, 649–654 (1998)

    Article  CAS  Google Scholar 

  47. D. Prangishvili, P. Forterre, R.A. Garrett: Viruses of the Archaea: a unifying view, Nat. Rev. Microbiol. 4, 837–848 (2006)

    Article  CAS  Google Scholar 

  48. K.S. Lundberg, D.D. Shoemaker, M.W.W. Adams, J.M. Short, J.A. Sorge, E.J. Mathur: High-fidelity amplification using a thermostable DNA polymerase isolated from Pyrococcus furiosus, Gene 108, 1–6 (1991)

    Article  CAS  Google Scholar 

  49. Y. Cho, H.S. Lee, Y.J. Kim, S.G. Kang, S.-J. Kim, J.-H. Lee: Characterization of a dUTPase from the hyperthermophilic Archaeon Thermococcus onnurineus NA1 and its application in polymerase chain reaction amplification, Mar. Biotechnology 9, 450–458 (2007)

    Article  CAS  Google Scholar 

  50. Y.H. Tapilatu, V. Grossi, M. Acquaviva, C. Militon, J.-C. Bertrand, P. Cuny: Isolation of hydrocarbon-degrading extremely halophilic Archaea from an uncontaminated hypersaline pond (Camargue, France), Extremophiles 14, 225–231 (2011)

    Article  CAS  Google Scholar 

  51. M.B. Karner, E.F. DeLong, D.M. Karl: Archaeal dominance in the mesopelagic zone of the Pacific Ocean, Nature 409, 507–510 (2001)

    Article  CAS  Google Scholar 

  52. J.S. Lipp, Y. Morono, F. Inagaki, K.-U. Hinrichs: Significant contribution of Archaea to extant biomass in marine subsurface sediments, Nature 454, 991–994 (2008)

    Article  CAS  Google Scholar 

  53. K.S. Lam: Discovery of novel metabolites from marine actinomycetes, Curr. Opin. Microbiol. 9, 245–251 (2006)

    Article  CAS  Google Scholar 

  54. L. Gram, J. Melchiorsen, J.B. Bruhn: Antibacterial activity of marine culturable bacteria collected from a global sampling of ocean surface waters and surface swabs of marine organisms, Mar. Biotechnology 12, 439–451 (2010)

    Article  CAS  Google Scholar 

  55. P.G. Williams: Panning for chemical gold: marine bacteria as a source of new therapeutics, Trends Biotechnol. 27, 45–52 (2009)

    Article  CAS  Google Scholar 

  56. L.T. Tan: Bioactive natural products from marine cyanobacteria for drug discovery, Phytochemistry 68, 954–979 (2007)

    Article  CAS  Google Scholar 

  57. A.M. Burja, B. Banaigs, E. Abou-Mansour, J. Grant Burgess, P.C. Wright: Marine cyanobacteria – a prolific source of natural products, Tetrahedron 57, 9347–9377 (2001)

    Article  CAS  Google Scholar 

  58. T.A. Gulder, B.S. Moore: Chasing the treasures of the sea – bacterial marine natural products, Curr. Opin. Microbiol. 12, 252–260 (2009)

    Article  CAS  Google Scholar 

  59. R.M. Weiner: Biopolymers from marine prokaryotes, Trends Biotechnol. 15, 390–394 (1997)

    Article  CAS  Google Scholar 

  60. M.W. Taylor, R. Radax, D. Steger, M. Wagner: Sponge-associated microorganisms: evolution, ecology, and biotechnological potential, Microbiol. Mol. Biol. Rev. 71, 295–347 (2007)

    Article  CAS  Google Scholar 

  61. K.L. Barott, B. Rodriguez-Brito, J. Janouškovec, K.L. Marhaver, J.E. Smith, P. Keeling, F.L. Rohwer: Microbial diversity associated with four functional groups of benthic reef algae and the reef-building coral Montastraea annularis, Environ. Microbiology 13, 1192–1204 (2011)

    Article  CAS  Google Scholar 

  62. G.M. Luna, F. Biavasco, R. Danovaro: Bacteria associated with the Rapid Tissue Necrosis [RTN] of stony corals, Environ. Microbiology 9, 1851–1857 (2007)

    Article  CAS  Google Scholar 

  63. G.M. Luna, L. Bongiorni, C. Gili, F. Biavasco, R. Danovaro: Vibrio harveyi as a causative agent of the White Syndrome in tropical stony corals, Environ. Microbiol. Report 2, 120–127 (2010)

    Article  Google Scholar 

  64. T.B. Brück, W.M. Brück, L.Z. Santiago-Vazquez, P.J. McCarthy, G.R. Kerr: Diversity of the bacterial communities associated with the azooxanthellate deep water octocorals Leptogorgia minimata, Iciligorgia schrammi, and Swiftia exertia, Mar. Biotechnology 9, 561–576 (2007)

    Article  CAS  Google Scholar 

  65. C.G. Di Camillo, G.M. Luna, M. Bo, G. Giordano, C. Corinaldesi, G. Bavestrello: Biodiversity of prokaryotic communities associated with the ectoderm of Ectopleura crocea (Cnidaria, Hydrozoa), PLoS ONE 7(6), e39926 (2012)

    Article  CAS  Google Scholar 

  66. S.K. Goffredi, W.J. Jones, H. Erhlich, A. Springer, R.C. Vrijenhoek: Epibiotic bacteria associated with the recently discovered Yeti crab, Kiwa hirsute, Environ. Microbiology 10, 2623–2634 (2008)

    Article  CAS  Google Scholar 

  67. T.-O. Watsuji, S. Nakagawa, S. Tsuchida, T. Toki, A. Hirota, U. Tsunogai, K. Takai: Diversity and function of epibiotic microbial communities on the galatheid crab, Shinkaia crosnieri, Microbes Environ. 25, 288–294 (2010)

    Article  Google Scholar 

  68. E. Armstrong, L. Yan, K.G. Boyd, P.C. Wright, J. Grant Burgess: The symbiotic role of marine microbes on living surfaces, Hydrobiology 461, 37–40 (2001)

    Article  Google Scholar 

  69. F. Rohwer, V. Seguritan, F. Azam, N. Knowlton: Diversity and distribution of coral-associated bacteria, Mar. Ecol. Prog. Ser. 243, 1–10 (2002)

    Article  Google Scholar 

  70. L. Wegley, Y.N. Yu, M. Breitbart, V. Casas, D.I. Kline, F. Rohwer: Coral-associated Archaea, Mar. Ecol. Prog. Ser. 273, 89–96 (2004)

    Article  CAS  Google Scholar 

  71. P.R. Jensen, W. Fenical: Strategies for the discovery of secondary metabolites from marine bacteria: ecological perspectives, Ann. Rev. Microbiol. 48, 559–584 (1994)

    Article  CAS  Google Scholar 

  72. T.R.A. Thomas, D.P. Kavlekar, P.A. LokaBharathi: Marine drugs from sponge-microbe association – a review, Mar. Drugs 8, 1417–1468 (2010)

    Article  CAS  Google Scholar 

  73. T. Amaro, G.M. Luna, R. Danovaro, D.S.M. Billett, M.R. Cunha: High prokaryotic biodiversity associated with gut contents of the holothurian Molpadia musculus from the Nazaré Canyon (NE Atlantic), Deep–Sea Res. I 63, 82–90 (2012)

    Article  Google Scholar 

  74. L.M. Sanchez, W.R. Wong, R.M. Riener, C.J. Schulze, R.G. Linington: Examining the fish microbiome: vertebrate-derived bacteria as an environmental niche for the discovery of unique marine natural products, PLoS ONE 7(5), e35398 (2012)

    Article  CAS  Google Scholar 

  75. S. Schneiker, V.A.P. Martins dos Santos, D. Bartels, T. Bekel, M. Brecht, J. Buhrmester, T.N. Chernikova, R. Denaro, M. Ferrer, C. Gertler, A. Goesmann, O.V. Golyshina, F. Kaminski, A.N. Khachane, S. Lang, B. Linke, A.C. McHardy, F. Meyer, T. Nechitaylo, A. Pühler, D. Regenhardt, O. Rupp, J.S. Sabirova, W. Selbitschka, M.M. Yakimov, K.N. Timmis, F.-J. Vorhölter, S. Weidner, O. Kaiser, P.N. Golyshin: Genome sequence of the ubiquitous hydrocarbon-degrading marine bacterium Alcanivorax borkumensis, Nat. Biotechnology 24, 997–1004 (2006)

    Article  CAS  Google Scholar 

  76. M.M. Yakimov, K.N. Timmis, P.N. Golyshin: Obligate oil-degrading marine bacteria, Curr. Opin. Biotechnol. 18, 257–266 (2007)

    Article  CAS  Google Scholar 

  77. A. Dell'Anno, F. Beolchini, L. Rocchetti, G.M. Luna, R. Danovaro: High bacterial biodiversity increases degradation performance of hydrocarbons during bioremediation of contaminated harbor marine sediments, Environ. Pollution 167, 85–92 (2012)

    Article  CAS  Google Scholar 

  78. P. Das, S. Mukherjee, C. Sivapathasekeran, R. Sen: Microbial surfactants of marine origin: potentials and prospects, Adv. Exp. Med. Biol. 672, 88–101 (2010)

    Article  CAS  Google Scholar 

  79. P.-Y. Qian, S.C.K. Lau, H.-U. Dahms, S. Dobretsov, T. Harder: Marine biofilms as mediators of colonization by marine macroorganisms: implications for antifouling and aquaculture, Mar. Biotechnology 9, 399–410 (2007)

    Article  CAS  Google Scholar 

  80. A.D. Barton, S. Dutkiewicz, G. Flierl, J. Bragg, M.J. Follows: Patterns of diversity in marine phytoplankton, Science 327, 1509–1511 (2010)

    Article  CAS  Google Scholar 

  81. F. Scheckenbach, K. Hausmann, C. Wylezich, M. Weitere, H. Arndt: Large-scale patterns in biodiversity of microbial eukaryotes from the abyssal sea floor, Proc. Natl. Acad. Sci. USA 107, 115–120 (2010)

    Article  CAS  Google Scholar 

  82. C. Raghukumar, Marine fungal biotechnology: an ecological perspective, Fungal Div. 31, 19–35 (2008)

    Google Scholar 

  83. L. Bongiorni: Thraustochytrids, a neglected component of organic matter composition and food webs in marine sediments. In: Biology of Marine Fungi Progr. Mol. Subcell. Biol, Vol. 53, ed. by C. Raghukumar (Springer-Verlag, Berlin Heidelberg 2012) pp. 1–13

    Google Scholar 

  84. T. Le Calvez, G. Burgaud, S. Mahé, G. Barbier, P. Vandenkoornhuyse: Fungal diversity in deep-sea hydrothermal ecosystems, Appl. Environ. Microbiol. 75, 6415–6421 (2009)

    Article  CAS  Google Scholar 

  85. T.A. Richards, M.D.M. Jones, G. Leonard, D. Bass: Marine fungi: their ecology and molecular diversity, Ann. Rev. Mar. Sci. 4, 495–522 (2012)

    Article  Google Scholar 

  86. S. Damare, P. Singh, S. Raghukumar: Biotechnology of marine fungi. In: Biology of Marine Fungi, Progr. Mol. Subcell. Biol, Vol. 53, ed. by C. Raghukumar (Springer-Verlag, Berlin Heidelberg 2012) pp. 277–297

    Google Scholar 

  87. M. Saleem, M.S. Ali, S. Hussain, A. Jabbar, M. Ashraf, Y.S. Lee: Marine natural products of fungal origin, Nat. Prod. Rep. 24, 1142–1152 (2007)

    Article  CAS  Google Scholar 

  88. D. Li, S. Cai, T. Zhu, F. Wang, X. Xiao, Q. Gu: Three new sorbicillin trimers, trisorbicillinones B, C, and D, from a deep ocean sediment derived fungus, Phialocephala sp. FL30r, Tetrahedron 27–28, 5101–5106 (2010)

    Article  CAS  Google Scholar 

  89. S. Damare, C. Raghukumar, S. Raghukumar: Fungi in deep-sea sediments of the Central Indian Basin, Deep-Sea Res. I 53, 14–27 (2006)

    Article  Google Scholar 

  90. M.T. Raikar, S. Raghukumar, V. Vani, J.J. David, D. Chandramohan: Thraustochytrid protists degrade hydrocarbons, Ind. J. Mar. Sci. 30, 139–145 (2001)

    CAS  Google Scholar 

  91. O. Pulz, W. Gross: Valuable products from biotechnology of microalgae, Appl. Microbiol. Biotechnol. 65, 635–648 (2004)

    Article  CAS  Google Scholar 

  92. O.M. Skulberg: Microalgae as a source of bioactive molecules – experience from cyanophyte research, J. Appl. Phycol. 12, 341–348 (2000)

    Article  CAS  Google Scholar 

  93. R.H. Wijffels, M.J. Barbosa: An outlook on microalgal biofuels, Science 329, 796–799 (2010)

    Article  CAS  Google Scholar 

  94. R.J.W. Brooijmans, R. Siezen: Genomics of microalgae, fuel for the future?, Microb. Biotechnology 3, 514–522 (2010)

    Article  CAS  Google Scholar 

  95. C. Fuentes-Grünewald, E. Garcés, S. Rossi, J. Camp: Use of the dinoflagellate Karlodinium veneficum as a sustainable source of biodiesel production, J. Industr. Microbiol. Biotechnol. 36, 1215–1224 (2009)

    Article  CAS  Google Scholar 

  96. V. Smetacek: Diatoms and the ocean carbon cycle, Protist 150, 25–32 (1999)

    Article  CAS  Google Scholar 

  97. E.V. Armbrust: The life of diatoms in the world's oceans, Nature 459, 185–192 (2009)

    Article  CAS  Google Scholar 

  98. M. Hildebrand, A.K. Davis, S.R. Smith, J.C. Traller, R. Abbriano: The place of diatoms in the biofuels industry, Biofuels 3, 221–240 (2012)

    Article  CAS  Google Scholar 

  99. T. Lebeau, J.-M. Robert: Diatom cultivation and biotechnologically relevant products. Part I: cultivation at various scales, Appl. Microbiol. Biotechnol. 60, 612–623 (2003)

    Article  CAS  Google Scholar 

  100. A. Bozarth, U.G. Maier, S. Zauren: Diatoms in biotechnology: modern tools and applications, Appl. Microbiol. Biotechnol. 82, 195–201 (2009)

    Article  CAS  Google Scholar 

  101. R.M. Van Wagoner, J.R. Deeds, M. Satake, A.A. Ribeiro, A.R. Place, J.L.C. Wright: Isolation and characterization of karlotoxin 1, a new amphipathic toxin from Karlodinium veneficum, Tetrahedron Lett. 49, 6457–6461 (2008)

    Article  CAS  Google Scholar 

  102. A.L. Waters, R.T. Hill, A.R. Place, M.T. Hamann: The expanding role of marine microbes in pharmaceutical development, Curr. Opin. Biotechnol. 21, 780–786 (2010)

    Article  CAS  Google Scholar 

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Correspondence to Gian M. Luna .

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© 2015 Springer-Verlag Berlin Heidelberg

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Luna, G.M. (2015). Biotechnological Potential of Marine Microbes. In: Kim, SK. (eds) Springer Handbook of Marine Biotechnology. Springer Handbooks. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-53971-8_26

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