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Cannabinoids: Metabolites Hydroxylated in the Pentyl Side Chain

  • Conference paper
Marihuana

Abstract

This chapter—which also covers recent unpublished results from our laboratory—is mainly concerned with cannabinoid metabolites hydroxylated in the side chain. Other aspects of cannabinoid metabolism have recently been reviewed in other volumes [4,5,12].

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References

  1. Agurell, S., J. Dahmén, H. Edery, K. Leander, and R. Mechoulam (1975) Synthesis and biological activity of side chain hydroxylated tetrahydrocannabinols. (To be published.)

    Google Scholar 

  2. Agurell, S., S. Levander, M. Binder, A. Bader-Bartfai, B. Gustafsson, K. Leander, J.-E. Lindgren, A. Ohlsson, and B. Tobisson (1975) Pharmacokinetics of Δ8-tetrahydrocannabinol in man after smoking —relations to physiological and psychological effects. The Pharmacology of Cannabis (M. Braude and S. Szara, eds.). Baltimore: University Park Press.

    Google Scholar 

  3. Binder, M., S. Agurell, K. Leander, and J.-E. Lindgren (1974) Zur identification potentieller metabolite von cannabis inhaltstoffen: kernresonanz und massenspektroskopische Untersuchungen an seiten-kettenhydrozylierten cannabinoiden. Helv. Chim. Acta57:1626.

    Article  PubMed  Google Scholar 

  4. Burstein, S., J. Martinez, J. Rosenfeld, and T. Wittstruck (1972) The general pharmacology of cannabinoids. Cannabis and Its Derivatives. (W. D. M. Paton, and J. Crown, eds.). London: Oxford University Press, pp. 39–49.

    Google Scholar 

  5. Burstein, S. H. (1973) Labeling and metabolism of the tetrahydrocannabinols. Marijuana (R. Mechoulam, ed.). New York: Academic Press, pp. 167–190.

    Google Scholar 

  6. Fahrenholtz, K. E. (1972) The synthesis of two metabolites of (-)-Δ8THC. J. Org. Chem.37:2204.

    Article  PubMed  Google Scholar 

  7. Fonseka, K., M. Widman, and S. Agurell (1976) Chromatographic separation of cannabinoids and their monooxygenated derivatives. J. Chromatogr. (in press).

    Google Scholar 

  8. Lander, N., Z. Ben-Zvi, R. Mechoulam, B. Martin, M. Nordqvist, and S. Agurell (1976) Total synthesis of cannabidiol and Δ1-tetrahydrocannabinol metabolites. J. Chem. Soc. (in press).

    Google Scholar 

  9. Lemberger, L., R. Martz, B. Rodda, R. Forney, and H. Rowe (1973) Comparative pharmacology of Δ9-THC and its metabolite, 11-OH-Δ9-THC. 7. Clin. Invest.52:2411.

    Article  Google Scholar 

  10. Martin, B., M. Nordqvist, S. Agurell, J.-E. Lindgren, and K. Leander (1976) Identification of monohydroxylated metabolites of cannabidiol formed by rat liver. J. Pharm. Pharmacol. (in press).

    Google Scholar 

  11. Maynard, D. E., O. Gurny, R. G Pitcher, and R. W. Kierstead (1971) (-)-Δ8THC. Two novel in vitro metabolites. Experientia27:1154.

    Article  PubMed  Google Scholar 

  12. Mechoulam, R., N. K. McCallum, and S. Burstein (1975) Recent advances in the chemistry and biochemistry of Cannabis. Chem. Rev. (in press).

    Google Scholar 

  13. Nilsson, I. M., S. Agurell, J. L. G. Nilsson, M. Widman, and K. Leander (1973) Two cannabidiol metabolites formed by rat liver. J. Pharm. Pharmacol.25:486.

    Article  PubMed  Google Scholar 

  14. Paton, W. D. M. (1975) Pharmacology of marijuana. Ann. Rev. Pharmacol.15:191.

    Article  PubMed  Google Scholar 

  15. Pitt, C. G., D. T. Hobbs, H. Schran, C. E. Twine, Jr., and D. L. Williams (1976) The synthesis of deuterium, carbon-14, and carrier-free tritium labelled cannabinoids. J. Org. Chem. (in press).

    Google Scholar 

  16. Wall, M. E. (1971) The in vitro and in vivo metabolism of tetrahydrocannabinol. Ann. N. Y. Acad. Sci.191:23.

    Article  Google Scholar 

  17. Widman, M., K. Dahmén, K. Leander, and K. Petersson (1975) In vitro metabolism of cannabinol in rat and rabbit liver. Synthesis of 2”-, 3”-, and 5”-hydroxycannabinol. Acta Pharm. Suec.12:385.

    PubMed  Google Scholar 

  18. Widman, M., M. Nordqvist, C. T. Dollery, and R. H. Briant (1975) Metabolism of A1-tetrahydrocannabinol by the isolated perfused dog lung. J. Pharm. Pharmacol.27:842.

    Article  PubMed  Google Scholar 

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Authors
  1. S. Agurell
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  2. M. Binder
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  3. K. Fonseka
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  4. J.-E. Lindgren
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  5. K. Leander
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  6. B. Martin
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  7. I. M. Nilsson
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  8. M. Nordqvist
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  9. A. Ohlsson
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  10. M. Widman
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Editor information

Editors and Affiliations

  1. College of Physicians & Surgeons of Columbia University, 630 West 168th Street, 10032, New York, New York, USA

    Gabriel G. Nahas M.D., Ph.D. (Research Professor of Anesthesiology) (Research Professor of Anesthesiology)

  2. University of Oxford, Oxford, England

    William D. M. Paton M.D., Ph.D. (Professor of Pharmacology) (Professor of Pharmacology)

  3. National Board of Health, Helsinki, 53, Finland

    Juhana E. Idänpään-Heikkilä M.D., D.M.Sc. (Docent, Chief Medical Officer for Pharmacology) (Docent, Chief Medical Officer for Pharmacology)

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© 1976 Springer-Verlag New York Inc.

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Agurell, S. et al. (1976). Cannabinoids: Metabolites Hydroxylated in the Pentyl Side Chain. In: Nahas, G.G., Paton, W.D.M., Idänpään-Heikkilä, J.E. (eds) Marihuana. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-51624-5_12

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  • DOI: https://doi.org/10.1007/978-3-642-51624-5_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-51626-9

  • Online ISBN: 978-3-642-51624-5

  • eBook Packages: Springer Book Archive

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